World's Best Scientists 2026 revealed!
David S. Knopman

David S. Knopman

Award Badge
Best Scientists
2025
Award Badge
Neuroscience
USA
2026

D-Index & Metrics

Best Scientists

D-Index
189
Citations
160452
World Ranking
440
National Ranking
293

Neuroscience

D-Index
201
Citations
181110
World Ranking
28
National Ranking
21

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Neuroscience in United States Leader Award

Overview

David S. Knopman is affiliated with the Mayo Clinic in the United States. Their research primarily focuses on medicine, with a significant concentration on psychiatry and mental health, physiology, neurology, cognitive neuroscience, and radiology, nuclear medicine, and imaging.

The scientist's work covers multiple major topics, including:

  • Dementia and Cognitive Impairment Research
  • Alzheimer's disease research and treatments
  • Functional Brain Connectivity Studies
  • Advanced Neuroimaging Techniques and Applications
  • Parkinson's Disease Mechanisms and Treatments
  • Amyotrophic Lateral Sclerosis Research
  • Neurological Disease Mechanisms and Treatments

They have contributed to a range of publications, often collaborating with other experts in the field. Frequent co-authors include Ronald C. Petersen, Clifford R. Jack, Prashanthi Vemuri, Jonathan Graff-Radford, and Val J. Lowe.

The scientist regularly publishes in established venues, including:

  • Alzheimer's & Dementia
  • Neurology
  • Journal of Alzheimer's Disease
  • Brain Communications
  • Nature Communications

Some of their recent significant papers are:

  • "Alzheimer disease," 2021, Nature Reviews Disease Primers
  • "Failure to demonstrate efficacy of aducanumab: An analysis of the EMERGE and ENGAGE trials as reported by Biogen, December 2019," 2020, Alzheimer's & Dementia
  • "Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease," 2020, Nature Communications
  • "TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A," 2022, Nature
  • "Performance of plasma phosphorylated tau 181 and 217 in the community," 2022, Nature Medicine

Best Publications

  • The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

    Guy M. McKhann;Guy M. McKhann;David S. Knopman;Howard Chertkow;Bradley T. Hyman

  • Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia.

    Katya Rascovsky;John R. Hodges;David Knopman;Mario F. Mendez

  • Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS

    Mariely DeJesus-Hernandez;Ian R. Mackenzie;Bradley F. Boeve;Adam L. Boxer

  • Classification of primary progressive aphasia and its variants

    M L Gorno-Tempini;M L Gorno-Tempini;A E Hillis;S Weintraub;A Kertesz

  • Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

    Clifford R Jack;David S Knopman;William J Jagust;Leslie M Shaw

  • Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers.

    Clifford R Jack;David S Knopman;William J Jagust;Ronald C Petersen

  • The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    G.M. McKhann;D.S. Knopman;H. Chertkow;B.T. Hyman

  • Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

    Clifford R. Jack;Marilyn S. Albert;David S. Knopman;Guy M. McKhann

  • A/T/N: An unbiased descriptive classification scheme for Alzheimer disease biomarkers

    Clifford R. Jack;David A. Bennett;Kaj Blennow;Maria C. Carrillo

  • Mild cognitive impairment: ten years later.

    Ronald Carl Petersen;Rosebud O Roberts;David S Knopman;Bradley F Boeve

  • Primary age-related tauopathy (PART): a common pathology associated with human aging

    John F. Crary;John Q. Trojanowski;Julie A. Schneider;Jose F. Abisambra

  • Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease.

    Clifford R. Jack Jr.;Val J. Lowe;Stephen D Weigand;Heather J. Wiste

  • A 30-Week Randomized Controlled Trial of High-Dose Tacrine in Patients With Alzheimer's Disease

    Margaret J. Knapp;David S. Knopman;Paul R. Solomon;William W. Pendlebury

  • Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

    Y. Iturria-Medina;R. C. Sotero;P. J. Toussaint;J. M. Mateos-Pérez

  • Comparison of Different MRI Brain Atrophy Rate Measures with Clinical Disease Progression in AD

    C. R. Jack;M. M. Shiung;J. L. Gunter;P. C. O'Brien

  • 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment.

    Clifford R. Jack;Val J. Lowe;Matthew L. Senjem;Stephen D. Weigand

  • Defining imaging biomarker cut points for brain aging and Alzheimer's disease

    Clifford R. Jack;Heather J. Wiste;Stephen D. Weigand;Terry M. Therneau

  • Prevalence of mild cognitive impairment is higher in men. The Mayo Clinic Study of Aging.

    R. C. Petersen;R. O. Roberts;D. S. Knopman;Y. E. Geda

  • Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery-2018.

    L. Evered;L. Evered;B. Silbert;B. Silbert;D. S. Knopman;D. A. Scott;D. A. Scott

  • Classification and epidemiology of MCI.

    Rosebud Roberts;David S. Knopman

  • Clinicopathological and imaging correlates of progressive aphasia and apraxia of speech.

    Keith A. Josephs;Joseph R. Duffy;Edyth A. Strand;Jennifer L. Whitwell

  • The Mayo Clinic Study of Aging: Design and Sampling, Participation, Baseline Measures and Sample Characteristics

    Rosebud O. Roberts;Yonas E. Geda;David S. Knopman;Ruth H. Cha

  • Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

    L. Evered;L. Evered;B. Silbert;B. Silbert;D.S. Knopman;D.A. Scott;D.A. Scott

  • Cognitive impairment in hemodialysis patients is common.

    Anne M Murray;David Tupper;David Tupper;D. S. Knopman;D. T. Gilbertson

  • Neuropathologic features of amnestic mild cognitive impairment.

    Ronald C. Petersen;Joseph E. Parisi;Dennis W. Dickson;Kris A. Johnson

Frequent Co-Authors

Ronald C. Petersen
Ronald C. Petersen University of Pennsylvania
Clifford R. Jack
Clifford R. Jack Mayo Clinic
Bradley F. Boeve
Bradley F. Boeve Mayo Clinic
Kejal Kantarci
Kejal Kantarci Mayo Clinic
Val J. Lowe
Val J. Lowe Mayo Clinic
Mary M. Machulda
Mary M. Machulda Mayo Clinic

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