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Chemistry

D-Index
69
Citations
21132
World Ranking
6102
National Ranking
383

Overview

Atsushi Harada is affiliated with Osaka Metropolitan University in Japan and has contributed extensively to research in materials science and biochemistry, genetics, and molecular biology. Their work spans multiple subfields including organic chemistry, molecular biology, biomedical engineering, biomaterials, and materials chemistry. The primary focus of their research involves advanced polymer synthesis and characterization, RNA interference and gene delivery, nanoparticle-based drug delivery, nanoplatforms for cancer theranostics, dendrimers and hyperbranched polymers, polymer surface interaction studies, and advanced biosensing and bioanalysis techniques.

The scientist has been published frequently in several academic journals. Key publication venues include:

  • ACS Applied Materials & Interfaces
  • ACS Applied Polymer Materials
  • Journal of Materials Chemistry B
  • Pharmaceutics
  • Molecules

Representative recent papers authored or co-authored by Atsushi Harada include:

  • "Cationic lipid potentiated the adjuvanticity of polysaccharide derivative-modified liposome vaccines" (2022), Journal of Controlled Release
  • "Development of Mannose-Modified Carboxylated Curdlan-Coated Liposomes for Antigen Presenting Cell Targeted Antigen Delivery" (2020), Pharmaceutics
  • "pH-Sensitive branched β-glucan-modified liposomes for activation of antigen presenting cells and induction of antitumor immunity" (2021), Journal of Materials Chemistry B
  • "Interfacial Photo-Cross-Linking: Simple but Powerful Approach for Fabricating Capsule Polymer Particles with Tunable pH-Responsive Controlled Release Capability" (2021), ACS Applied Materials & Interfaces
  • "Multifunctional Traceable Liposomes with Temperature-Triggered Drug Release and Neovasculature-Targeting Properties for Improved Cancer Chemotherapy" (2021), Molecular Pharmaceutics

Their research network includes frequent collaborations with several coauthors, notably:

  • Yukiya Kitayama
  • Eiji Yuba
  • Shin Yanagihara
  • Nozomi Kasho
  • Takuya Hashimoto

Atsushi Harada's body of work demonstrates extensive engagement with the development and functionalization of polymeric and liposomal systems for biomedical applications. This includes targeting of antigen-presenting cells, stimuli-responsive drug delivery platforms, and cancer chemotherapy enhancements.

Best Publications

  • Block copolymer micelles for drug delivery: design, characterization and biological significance

    Kazunori Kataoka;Atsushi Harada;Yukio Nagasaki

  • Design of environment-sensitive supramolecular assemblies for intracellular drug delivery: polymeric micelles that are responsive to intracellular pH change.

    Younsoo Bae;Shigeto Fukushima;Atsushi Harada;Kazunori Kataoka

  • Formation of Polyion Complex Micelles in an Aqueous Milieu from a Pair of Oppositely-Charged Block Copolymers with Poly(ethylene glycol) Segments

    Atsushi Harada;Kazunori Kataoka

  • Chain Length Recognition: Core-Shell Supramolecular Assembly from Oppositely Charged Block Copolymers

    Atsushi Harada;Kazunori Kataoka

  • Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.

    Kanjiro Miyata;Yoshinori Kakizawa;Nobuhiro Nishiyama;Atsushi Harada

  • Supramolecular assemblies of block copolymers in aqueous media as nanocontainers relevant to biological applications

    Atsushi Harada;Kazunori Kataoka

  • Novel polyion complex micelles entrapping enzyme molecules in the core: Preparation of narrowly-distributed micelles from lysozyme and poly(ethylene glycol)-poly(aspartic acid) block copolymer in aqueous medium

    Atsushi Harada;Kazunori Kataoka

  • Spontaneous Formation of Polyion Complex Micelles with Narrow Distribution from Antisense Oligonucleotide and Cationic Block Copolymer in Physiological Saline.

    Kazunori Kataoka;Hideyuki Togawa;Atsushi Harada;Kenji Yasugi

  • Glucose-responsive polymer bearing a novel phenylborate derivative as a glucose-sensing moiety operating at physiological pH conditions.

    Akira Matsumoto;Syuhei Ikeda;and Atsushi Harada;Kazunori Kataoka

  • Polyion complex micelles as vectors in gene therapy – pharmacokinetics and in vivo gene transfer

    M Harada-Shiba;K Yamauchi;A Harada;I Takamisawa

  • Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency.

    Keiji Itaka;Kyosuke Yamauchi;Atsushi Harada;Kozo Nakamura

  • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine

    Keiji Itaka;Atsushi Harada;Yuichi Yamasaki;Kozo Nakamura

  • Preparation and cytotoxic activity of poly(ethylene glycol)-modified poly(amidoamine) dendrimers bearing adriamycin.

    Kenji Kono;Chie Kojima;Nobuyuki Hayashi;Eiko Nishisaka

  • Polyion complex micelles entrapping cationic dendrimer porphyrin: effective photosensitizer for photodynamic therapy of cancer

    Guo Dong Zhang;Atsushi Harada;Nobuhiro Nishiyama;Dong Lin Jiang

  • Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer.

    Ryuichi Ideta;Fumitaka Tasaka;Woo Dong Jang;Nobuhiro Nishiyama

  • Rendering poly(amidoamine) or poly(propylenimine) dendrimers temperature sensitive.

    Yasuhiro Haba;Atsushi Harada;Toru Takagishi;Kenji Kono

  • PEGylated PAMAM dendrimer-doxorubicin conjugate-hybridized gold nanorod for combined photothermal-chemotherapy.

    Xiaojie Li;Munenobu Takashima;Eiji Yuba;Atsushi Harada

  • A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy.

    Eiji Yuba;Atsushi Harada;Yuichi Sakanishi;Shinobu Watarai

  • Highly temperature-sensitive liposomes based on a thermosensitive block copolymer for tumor-specific chemotherapy.

    Kenji Kono;Toshiaki Ozawa;Tomohide Yoshida;Fuminori Ozaki

  • Preparation of poly(ethylene glycol)-attached dendrimers encapsulating photosensitizers for application to photodynamic therapy.

    Chie Kojima;Yoko Toi;and Atsushi Harada;Kenji Kono

Frequent Co-Authors

Kenji Kono
Kenji Kono Osaka Metropolitan University
Kazunori Kataoka
Kazunori Kataoka University of Tokyo
Yukio Nagasaki
Yukio Nagasaki University of Tsukuba
Nobuhiro Nishiyama
Nobuhiro Nishiyama Tokyo Institute of Technology
Keiji Itaka
Keiji Itaka Tokyo Medical and Dental University
Takuzo Aida
Takuzo Aida University of Tokyo
Kozo Nakamura
Kozo Nakamura Shinshu University
Sadahito Aoshima
Sadahito Aoshima Osaka University
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo
Kazuo Sakurai
Kazuo Sakurai The University of Kitakyushu

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