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D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
9445
World Ranking
16231
National Ranking
1163

Overview

Keiji Itaka is affiliated with Tokyo Medical and Dental University in Japan. Their research primarily spans the fields of biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology, genetics, rheumatology, biomedical engineering, and surgery as subfields.

The key research topics addressed in their work include RNA interference and gene delivery, osteoarthritis treatment and mechanisms, RNA and protein synthesis mechanisms, virus-based gene therapy research, advanced biosensing and bioanalysis techniques, RNA research and splicing, and ultrasound and hyperthermia applications.

Frequent co-authors collaborating with Keiji Itaka are Hideyuki Nakanishi, Yuta Fukushima, Xuan Du, Yuki Terai, and Kazunori Kataoka.

Their publications frequently appear in journals such as Drug Delivery System, Pharmaceutics, ACS Synthetic Biology, Nanomaterials, and Journal of Controlled Release.

Selected recent papers include:

  • Treatment of ischemic neuronal death by introducing brain-derived neurotrophic factor mRNA using polyplex nanomicelle (2021, Biomaterials)
  • Brain Dp140 alters glutamatergic transmission and social behaviour in the mdx52 mouse model of Duchenne muscular dystrophy (2022, Progress in Neurobiology)
  • Enhancement of bone regeneration by coadministration of angiogenic and osteogenic factors using messenger RNA (2023, Inflammation and Regeneration)
  • Raman spectroscopic insight into osteoarthritic cartilage regeneration by mRNA therapeutics encoding cartilage-anabolic transcription factor Runx1 (2022, Materials Today Bio)
  • Efficient Messenger RNA Delivery to the Kidney Using Renal Pelvis Injection in Mice (2021, Pharmaceutics)

Best Publications

  • PEG-Detachable Polyplex Micelles Based on Disulfide-Linked Block Catiomers as Bioresponsive Nonviral Gene Vectors

    Seiji Takae;Kanjiro Miyata;Makoto Oba;Takehiko Ishii

  • 3D spheroid culture system on micropatterned substrates for improved differentiation efficiency of multipotent mesenchymal stem cells

    Wenjie Wang;Keiji Itaka;Shinsuke Ohba;Nobuhiro Nishiyama

  • Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer

    Nobuhiro Nishiyama;Aya Iriyama;Woo Dong Jang;Kanjiro Miyata

  • Polyion complex micelles from plasmid DNA and poly(ethylene glycol)-poly(L-lysine) block copolymer as serum-tolerable polyplex system: physicochemical properties of micelles relevant to gene transfection efficiency.

    Keiji Itaka;Kyosuke Yamauchi;Atsushi Harada;Kozo Nakamura

  • Glycaemic control boosts glucosylated nanocarrier crossing the BBB into the brain

    Y. Anraku;H. Kuwahara;Y. Fukusato;A. Mizoguchi

  • In situ single cell observation by fluorescence resonance energy transfer reveals fast intra‐cytoplasmic delivery and easy release of plasmid DNA complexed with linear polyethylenimine

    Keiji Itaka;Atsushi Harada;Yuichi Yamasaki;Kozo Nakamura

  • Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity.

    Keiji Itaka;Takehiko Ishii;Yoko Hasegawa;Kazunori Kataoka

  • Odd-even effect of repeating aminoethylene units in the side chain of N-substituted polyaspartamides on gene transfection profiles.

    Hirokuni Uchida;Kanjiro Miyata;Makoto Oba;Takehiko Ishii

  • A PEG-based biocompatible block catiomer with high buffering capacity for the construction of polyplex micelles showing efficient gene transfer toward primary cells.

    Naoki Kanayama;Shigeto Fukushima;Nobuhiro Nishiyama;Keiji Itaka

  • Efficient delivery of bioactive antibodies into the cytoplasm of living cells by charge-conversional polyion complex micelles

    Yan Lee;Takehiko Ishii;Hyun Jin Kim;Nobuhiro Nishiyama

  • Supramolecular nanocarrier of siRNA from PEG-based block catiomer carrying diamine side chain with distinctive pKa directed to enhance intracellular gene silencing.

    Keiji Itaka;Naoki Kanayama;Nobuhiro Nishiyama;Woo Dong Jang

  • Recent development of nonviral gene delivery systems with virus-like structures and mechanisms.

    Keiji Itaka;Kazunori Kataoka

  • Lactose-conjugated polyion complex micelles incorporating plasmid DNA as a targetable gene vector system: their preparation and gene transfecting efficiency against cultured HepG2 cells.

    Daisuke Wakebayashi;Nobuhiro Nishiyama;Yuichi Yamasaki;Keiji Itaka

  • Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6.

    Toru Ogasawara;Hiroshi Kawaguchi;Shigeki Jinno;Kazuto Hoshi

  • Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking.

    Makoto Oba;Kazuhiro Aoyagi;Kanjiro Miyata;Yu Matsumoto

  • Polyunsaturated fatty acids selectively suppress sterol regulatory element-binding protein-1 through proteolytic processing and autoloop regulatory circuit

    Yoshinori Takeuchi;Naoya Yahagi;Yoshihiko Izumida;Makiko Nishi

  • Modulated Protonation of Side Chain Aminoethylene Repeats in N-Substituted Polyaspartamides Promotes mRNA Transfection

    Hirokuni Uchida;Keiji Itaka;Takahiro Nomoto;Takehiko Ishii

  • Bone regeneration by regulated in vivo gene transfer using biocompatible polyplex nanomicelles

    Keiji Itaka;Shinsuke Ohba;Kanjiro Miyata;Hiroshi Kawaguchi

  • Evaluation by fluorescence resonance energy transfer of the stability of nonviral gene delivery vectors under physiological conditions.

    Keiji Itaka;Atsushi Harada;Kozo Nakamura;Hiroshi Kawaguchi

  • Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

    Satoshi Uchida;Hiroaki Kinoh;Takehiko Ishii;Akitsugu Matsui

Frequent Co-Authors

Kazunori Kataoka
Kazunori Kataoka University of Tokyo
Nobuhiro Nishiyama
Nobuhiro Nishiyama Tokyo Institute of Technology
Kanjiro Miyata
Kanjiro Miyata University of Tokyo
Ung-il Chung
Ung-il Chung University of Tokyo
Kozo Nakamura
Kozo Nakamura Shinshu University
Hiroshi Kawaguchi
Hiroshi Kawaguchi University of Tokyo
Woo Dong Jang
Woo Dong Jang Yonsei University
Yukio Nagasaki
Yukio Nagasaki University of Tsukuba
Atsushi Harada
Atsushi Harada Osaka Metropolitan University
Naoya Yahagi
Naoya Yahagi University of Tsukuba

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