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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Molecular Biology

D-Index
120
Citations
50785
World Ranking
260
National Ranking
24

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2017 - Member of the European Academy of Sciences

Overview

Ernst Wagner is affiliated with Ludwig-Maximilians-Universität München in Germany and has a significant body of work primarily in the field of Biochemistry, Genetics and Molecular Biology. Their research spans a range of subfields including Molecular Biology, Genetics, Biomedical Engineering, Immunology, and Biomaterials.

The scientist's research topics cover several areas within molecular and biomedical research. These include RNA Interference and Gene Delivery, Advanced Biosensing and Bioanalysis Techniques, Virus-Based Gene Therapy Research, CRISPR and Genetic Engineering, Nanoparticle-Based Drug Delivery, CAR-T Cell Therapy Research, and MicroRNA in Disease Regulation.

Ernst Wagner has contributed to several recent papers, highlighting their focus on delivery systems and cancer therapeutics. These publications include:

  • A Multistage Cooperative Nanoplatform Enables Intracellular Co-Delivery of Proteins and Chemotherapeutics for Cancer Therapy (2020, Advanced Materials)
  • Non-viral delivery of the CRISPR/Cas system: DNA versus RNA versus RNP (2022, Biomaterials Science)
  • From structural design to delivery: mRNA therapeutics for cancer immunotherapy (2023, Exploration)
  • Optimizing synthetic nucleic acid and protein nanocarriers: The chemical evolution approach (2020, Advanced Drug Delivery Reviews)
  • Nucleic Acid-Based Approaches for Tumor Therapy (2020, Cells)

Their frequent co-authors include Ulrich Lächelt, Miriam Höhn, Simone Berger, Mina Yazdi, and Ulrich Wilk, indicating ongoing collaborative efforts across various projects.

Publications by Ernst Wagner are often featured in journals such as Journal of Controlled Release, Bioconjugate Chemistry, Pharmaceutics, Molecular Therapy - Oncolytics, and Macromolecular Rapid Communications. This range points to a strong focus on controlled drug delivery systems and related biochemical and molecular technologies.

Ernst Wagner was awarded membership to the European Academy of Sciences in 2017.

Best Publications

  • Transferrin-polycation conjugates as carriers for DNA uptake into cells

    Ernst Wagner;Martin Zenke;Matt Cotten;Hartmut Beug

  • The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

    Christian Plank;Berndt Oberhauser;Karl Mechtler;Christian Koch

  • Influenza virus hemagglutinin HA-2 N-terminal fusogenic peptides augment gene transfer by transferrin-polylysine-DNA complexes: toward a synthetic virus-like gene-transfer vehicle.

    Ernst Wagner;Christian Plank;Kurt Zatloukal;Matt Cotten

  • Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

    David T. Curiel;Santosh Agarwal;Ernst Wagner;Matt Cotten

  • Different behavior of branched and linear polyethylenimine for gene delivery in vitro and in vivo.

    Lionel Wightman;Ralf Kircheis;Vanessa Rössler;Sebastian Carotta

  • Design and gene delivery activity of modified polyethylenimines

    Ralf Kircheis;Lionel Wightman;Ernst Wagner

  • Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

    Christian Plank;Karl Mechtler;Francis C. Szoka;Ernst Wagner

  • Transferrin-polycation-DNA complexes: the effect of polycations on the structure of the complex and DNA delivery to cells.

    Ernst Wagner;Matt Cotten;Roland Foisner;Max L. Birnstiel

  • Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

    Ernst Wagner;Kurt Zatloukal;Matt Cotten;Helen Kirlappos

  • Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

    S Brunner;T Sauer;S Carotta;M Cotten

  • Polylysine-based transfection systems utilizing receptor-mediated delivery.

    Wolfgang Zauner;Manfred Ogris;Ernst Wagner

  • Nomenclature for Synthetic Gene Delivery Systems

    P. L. Felgner;Y. Barenholz;J. P. Behr;S. H. Cheng

  • Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

    Ulrich Lächelt;Ulrich Lächelt;Ernst Wagner;Ernst Wagner

  • Simple modifications of branched PEI lead to highly efficient siRNA carriers with low toxicity.

    Arkadi Zintchenko;Alexander Philipp;Ali Dehshahri;Ernst Wagner

  • High-efficiency receptor-mediated delivery of small and large (48 kilobase gene constructs using the endosome-disruption activity of defective or chemically inactivated adenovirus particles

    Matt Cotten;Ernst Wagner;Kurt Zatloukal;Stephen Phillips

  • Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer.

    Sabine Boeckle;Katharina von Gersdorff;Silke van der Piepen;Carsten Culmsee

  • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

    Matt Cotten;Francoise Längle-Rouault;Helen Kirlappos;Ernst Wagner

  • Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery

    R Kircheis;A Kichler;G Wallner;M Kursa

  • Polycation-based DNA complexes for tumor-targeted gene delivery in vivo.

    Ralf Kircheis;Susanne Schüller;Sylvia Brunner;Manfred Ogris

  • Effective incorporation of 2'-O-methyl-oligoribonucleotides into liposomes and enhanced cell association through modification with thiocholesterol.

    Berndt Oberhauser;Ernst Wagner

Frequent Co-Authors

Matthew Cotten
Matthew Cotten Wellcome Sanger Institute
Manfred Ogris
Manfred Ogris University of Vienna
Max L. Birnstiel
Max L. Birnstiel Research Institute of Molecular Pathology
David T. Curiel
David T. Curiel Washington University in St. Louis
Christian Plank
Christian Plank Technical University of Munich
Joachim O. Rädler
Joachim O. Rädler Ludwig-Maximilians-Universität München
Christoph Bräuchle
Christoph Bräuchle Ludwig-Maximilians-Universität München
Carsten Culmsee
Carsten Culmsee Philipp University of Marburg
Karl Mechtler
Karl Mechtler Research Institute of Molecular Pathology
Angelika M. Vollmar
Angelika M. Vollmar Ludwig-Maximilians-Universität München

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