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Stefaan C. De Smedt

Stefaan C. De Smedt

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
105
Citations
36131
World Ranking
1209
National Ranking
19

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2018 - Member of the European Academy of Sciences

Overview

Stefaan C. De Smedt is affiliated with Ghent University in Belgium and specializes in research spanning biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their work covers multiple subfields, including molecular biology, biomedical engineering, immunology, radiology, nuclear medicine and imaging, and materials chemistry.

Their research topics focus primarily on RNA interference and gene delivery, advanced biosensing and bioanalysis techniques, immunotherapy and immune responses, CAR-T cell therapy research, nanoplatforms for cancer theranostics, virus-based gene therapy research, and nanoparticle-based drug delivery.

De Smedt has published extensively in several notable venues. Frequent publication outlets include:

  • Journal of Controlled Release
  • Advanced Drug Delivery Reviews
  • International Journal of Molecular Sciences
  • European Journal of Pharmaceutics and Biopharmaceutics
  • SSRN Electronic Journal

The scientist has coauthored many works with collaborators such as Kevin Braeckmans, Katrien Remaut, Ine Lentacker, Félix Sauvage, and Juan C. Fraire.

Some recent significant publications authored or coauthored by Stefaan C. De Smedt include:

  • The dawn of mRNA vaccines: The COVID-19 case (2021), Journal of Controlled Release
  • Macrophages as a therapeutic target to promote diabetic wound healing (2022), Molecular Therapy
  • Photothermal nanofibres enable safe engineering of therapeutic cells (2021), Nature Nanotechnology
  • Stimuli-responsive nanobubbles for biomedical applications (2021), Chemical Society Reviews
  • Opening doors with ultrasound and microbubbles: Beating biological barriers to promote drug delivery (2021), Advanced Drug Delivery Reviews

In recognition of their contributions to science, Stefaan C. De Smedt was awarded membership in the European Academy of Sciences in 2018.

Best Publications

  • HYALURONAN : PREPARATION, STRUCTURE, PROPERTIES, AND APPLICATIONS

    Lubomír Lapčík;Stefaan De Smedt;Joseph Demeester;Peter Chabreček

  • Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation

    Stefaan J. Soenen;Pilar Rivera-Gil;José-María Montenegro;Wolfgang J. Parak

  • The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

    Dries Vercauteren;Roosmarijn E. Vandenbroucke;Arwyn Tomos Jones;Joanna Rejman

  • Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles.

    Sander A.A. Kooijmans;Stephan Stremersch;Kevin Braeckmans;Stefaan C. de Smedt

  • Release mechanisms for polyelectrolyte capsules.

    Bruno G. De Geest;Niek N. Sanders;Gleb B. Sukhorukov;Joseph Demeester

  • Biodegradable polymers as non-viral carriers for plasmid DNA delivery.

    Jordy Luten;Cornelus F. van Nostrum;Stefaan C. De Smedt;Wim E. Hennink

  • N(1)-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.

    Oliwia Andries;Séan Mc Cafferty;Stefaan C. De Smedt;Ron Weiss

  • Ecofriendly Electrospun Membranes Loaded with Visible-Light-Responding Nanoparticles for Multifunctional Usages: Highly Efficient Air Filtration, Dye Scavenging, and Bactericidal Activity

    Dan Lv;Ruoxue Wang;Guosheng Tang;Zhipeng Mou

  • Lipid and polymer nanoparticles for drug delivery to bacterial biofilms

    Katrien Forier;Koen Raemdonck;Stefaan C. De Smedt;Jo Demeester

  • Encoding microcarriers: present and future technologies

    Kevin Braeckmans;Stefaan C. De Smedt;Marc Leblans;Rudi Pauwels

  • The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type

    Katharina von Gersdorff;Niek N. Sanders;Roosmarijn Vandenbroucke;Stefaan C. De Smedt

  • mRNA as gene therapeutic: how to control protein expression.

    Geertrui Tavernier;Oliwia Andries;Jo Demeester;Niek N. Sanders

  • Three-Dimensional Fluorescence Recovery after Photobleaching with the Confocal Scanning Laser Microscope

    Kevin Braeckmans;Liesbeth Peeters;Niek N. Sanders;Stefaan C. De Smedt

  • The dawn of mRNA vaccines: The COVID-19 case.

    Rein Verbeke;Ine Lentacker;Stefaan C. De Smedt;Heleen Dewitte

  • Design and evaluation of doxorubicin-containing microbubbles for ultrasound-triggered doxorubicin delivery: cytotoxicity and mechanisms involved

    Ine Lentacker;Bart Geers;Joseph Demeester;Stefaan C De Smedt

  • Polyelectrolyte microcapsules for biomedical applications

    Bruno G. De Geest;Bruno G. De Geest;Stefaan De Koker;Gleb B. Sukhorukov;Oliver Kreft

  • Type I IFN Counteracts the Induction of Antigen-Specific Immune Responses by Lipid-Based Delivery of mRNA Vaccines

    Charlotte Pollard;Charlotte Pollard;Joanna Rejman;Winni De Haes;Bernard Verrier

  • Intracellular delivery of nanomaterials: how to catch endosomal escape in the act

    Thomas F. Martens;Katrien Remaut;Jo Demeester;Stefaan C. De Smedt

  • Cystic fibrosis sputum: a barrier to the transport of nanospheres.

    Niek N. Sanders;Stefaan C. De Smedt;Elsa Van Rompaey;Paul Simoens

  • Particulate vaccines: on the quest for optimal delivery and immune response.

    Marie-Luce De Temmerman;Joanna Rejman;Jo Demeester;Darrell J. Irvine

Frequent Co-Authors

Niek N. Sanders
Niek N. Sanders Ghent University
Koen Raemdonck
Koen Raemdonck Ghent University
Bruno G. De Geest
Bruno G. De Geest Ghent University
Ranhua Xiong
Ranhua Xiong Nanjing Forestry University
Wim E. Hennink
Wim E. Hennink Utrecht University
Chaobo Huang
Chaobo Huang Nanjing Forestry University
Karine Breckpot
Karine Breckpot Vrije Universiteit Brussel
Andre G. Skirtach
Andre G. Skirtach Ghent University
Wolfgang J. Parak
Wolfgang J. Parak Universität Hamburg

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