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Roosmarijn E. Vandenbroucke

Roosmarijn E. Vandenbroucke

D-Index & Metrics

Biology and Biochemistry

D-Index
63
Citations
15486
World Ranking
10141
National Ranking
186

Overview

Roosmarijn E. Vandenbroucke is affiliated with Ghent University in Belgium and conducts research primarily in the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Neuroscience. Their work spans subfields including Molecular Biology, Neurology, Physiology, Immunology, and Biological Psychiatry. The research topics they focus on include Neuroinflammation and Neurodegeneration Mechanisms, Extracellular vesicles in disease, Alzheimer's disease research and treatments, Tryptophan and brain disorders, Immune cells in cancer, MicroRNA in disease regulation, and Bacterial Infections and Vaccines.

Vandenbroucke has contributed to numerous scientific publications, with some recent papers listed below:

  • Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization, 2021, Nature Neuroscience
  • The power of imaging to understand extracellular vesicle biology in vivo, 2021, Nature Methods
  • The Impact of Systemic Inflammation on Alzheimer's Disease Pathology, 2022, Frontiers in Immunology
  • Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation, 2022, Nature Immunology
  • The tremendous biomedical potential of bacterial extracellular vesicles, 2022, Trends in Biotechnology

The scientist has frequently published in journals such as Frontiers in Immunology, bioRxiv (Cold Spring Harbor Laboratory), Acta Neuropathologica Communications, Alzheimer's & Dementia, and the Journal of Extracellular Vesicles.

Frequent coauthors in their research include:

  • Elien Van Wonterghem
  • Lien Van Hoecke
  • Charysse Vandendriessche
  • Griet Van Imschoot
  • Junhua Xie

Vandenbroucke's research engages deeply with the biological and molecular pathways underlying neurological diseases, with a notable focus on the interaction between immune responses and brain pathologies. Their work on extracellular vesicles intersects multiple domains including neuroinflammation, cancer immunology, and bacterial infections, indicative of a broad and interdisciplinary approach.

Best Publications

  • A single-cell atlas of mouse brain macrophages reveals unique transcriptional identities shaped by ontogeny and tissue environment.

    Hannah Van Hove;Liesbet Martens;Isabelle Scheyltjens;Karen De Vlaminck

  • Is there new hope for therapeutic matrix metalloproteinase inhibition

    Roosmarijn E. Vandenbroucke;Claude Libert

  • The Use of Inhibitors to Study Endocytic Pathways of Gene Carriers: Optimization and Pitfalls

    Dries Vercauteren;Roosmarijn E. Vandenbroucke;Arwyn Tomos Jones;Joanna Rejman

  • Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization.

    Ana Rita Pombo Antunes;Isabelle Scheyltjens;Francesca Lodi;Julie Messiaen

  • Nanobodies as therapeutics: big opportunities for small antibodies

    Sophie Steeland;Roosmarijn E. Vandenbroucke;Claude Libert

  • The Internalization Route Resulting in Successful Gene Expression Depends on both Cell Line and Polyethylenimine Polyplex Type

    Katharina von Gersdorff;Niek N. Sanders;Roosmarijn Vandenbroucke;Stefaan C. De Smedt

  • Intracellularly Degradable Polyelectrolyte Microcapsules

    B. G. De Geest;R. E. Vandenbroucke;A. M. Guenther;G. B. Sukhorukov

  • Endothelial LRP1 transports amyloid-β1–42 across the blood-brain barrier

    Steffen E. Storck;Sabrina Meister;Julius Nahrath;Julius N. Meißner

  • Identification of a novel mechanism of blood–brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles

    Sriram Balusu;Elien Van Wonterghem;Riet De Rycke;Koen Raemdonck

  • The power of imaging to understand extracellular vesicle biology in vivo.

    Frederik J. Verweij;Leonora Balaj;Chantal M. Boulanger;David R.F. Carter

  • A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

    Sofie Voet;Conor Mc Guire;Nora Hagemeyer;Arne Martens

  • Ultrasound-Responsive Polymer-Coated Microbubbles That Bind and Protect DNA

    Ine Lentacker;Bruno G. De Geest;Roosmarijn E. Vandenbroucke;Liesbeth Peeters

  • An inflammatory triangle in psoriasis: TNF, type I IFNs and IL-17

    Lynda Grine;Lien Dejager;Claude Libert;Roosmarijn E. Vandenbroucke

  • Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop

    Ashley E. Russell;Alexandra Sneider;Kenneth W. Witwer;Paolo Bergese

  • Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases

    Marjana Brkic;Sriram Balusu;Claude Libert;Roosmarijn E. Vandenbroucke

  • Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice.

    Tom Vanden Berghe;Paco Hulpiau;Liesbet Martens;Roosmarijn E. Vandenbroucke

  • Treatment of TNF mediated diseases by selective inhibition of soluble TNF or TNFR1.

    Filip Van Hauwermeiren;Roosmarijn E. Vandenbroucke;Claude Libert

  • Amyloid β Oligomers Disrupt Blood–CSF Barrier Integrity by Activating Matrix Metalloproteinases

    Marjana Brkic;Sriram Balusu;Elien Van Wonterghem;Nina Gorlé

  • Into rather unexplored terrain : transcellular transport across the blood-brain barrier

    Marijke De Bock;Valérie Van Haver;Roosmarijn E. Vandenbroucke;Elke Decrock

  • A therapeutic role for matrix metalloproteinase inhibitors in lung diseases

    Roosmarijn Vandenbroucke;Eline Dejonckheere;Claude Libert

Frequent Co-Authors

Claude Libert
Claude Libert Ghent University
Stefaan C. De Smedt
Stefaan C. De Smedt Ghent University
Niek N. Sanders
Niek N. Sanders Ghent University
Riet De Rycke
Riet De Rycke Ghent University
Lieve Moons
Lieve Moons KU Leuven
Freddy Haesebrouck
Freddy Haesebrouck Ghent University
Luc Leybaert
Luc Leybaert Ghent University
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Richard Ducatelle
Richard Ducatelle Ghent University

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