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Luc Leybaert

Luc Leybaert

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
16805
World Ranking
5707
National Ranking
93

Overview

Luc Leybaert is affiliated with Ghent University in Belgium and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research primarily focuses on molecular biology and cardiology, with particular attention to cellular and molecular neuroscience and genetics.

The scientist's work covers a range of topics including connexins and lens biology, cardiac electrophysiology and arrhythmias, ion channel regulation and function, nicotinic acetylcholine receptors study, reproductive biology and fertility, barrier structure and function studies, and neuroscience and neuropharmacology research.

Recent publications highlight research into intercellular communication and signaling, with studies published in several notable journals. Key papers include:

  • "Glial Connexins and Pannexins in the Healthy and Diseased Brain," 2020, Physiological Reviews
  • "Cx43 Hemichannel Microdomain Signaling at the Intercalated Disc Enhances Cardiac Excitability," 2021, Journal of Clinical Investigation
  • "Intercellular Communication in the Heart: Therapeutic Opportunities for Cardiac Ischemia," 2020, Trends in Molecular Medicine
  • "Cx43 Channels and Signaling via IP3/Ca2+, ATP, and ROS/NO Propagate Radiation-Induced DNA Damage to Non-Irradiated Brain Microvascular Endothelial Cells," 2020, Cell Death and Disease
  • "Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage," 2020, Frontiers in Pharmacology

Frequent coauthors involved in shared research efforts include:

  • Katja Witschas
  • Maarten De Smet
  • Alessio Lissoni
  • Geert Bultynck
  • Christian Vanhove

Luc Leybaert has published repeatedly in prominent scientific venues, with multiple contributions in:

  • Frontiers in Physiology
  • Cellular and Molecular Life Sciences
  • Glia
  • PLoS ONE
  • Journal of Clinical Investigation

Their work integrates molecular mechanisms underlying cellular communication, particularly connexins, with implications in cardiac physiology and neural tissue function. The research includes investigating ion channel regulation, signaling pathways involving connexin hemichannels, and the effects of these processes on cellular and tissue health.

Best Publications

  • Engaging neuroscience to advance translational research in brain barrier biology

    Edward A. Neuwelt;Björn Bauer;Christoph Fahlke;Gert Fricker

  • The gap junction cellular internet: connexin hemichannels enter the signalling limelight.

    W. Howard Evans;Elke De Vuyst;Luc Leybaert

  • Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.

    Tania Løve Aaes;Agnieszka Kaczmarek;Tinneke Delvaeye;Bram De Craene

  • Intercellular Ca2+ Waves: Mechanisms and Function

    Luc Leybaert;Michael J. Sanderson

  • Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men.

    E. Heytens;J. Parrington;K. Coward;K. Coward;C. Young

  • Intracellular calcium changes trigger connexin 32 hemichannel opening

    Elke De Vuyst;Elke Decrock;Liesbet Cabooter;George R Dubyak

  • Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

    Nan Wang;Elke De Vuyst;Raf Ponsaerts;Kerstin Boengler

  • Connexin-related signaling in cell death: to live or let die?

    E Decrock;M Vinken;E De Vuyst;D V Krysko

  • Connexin and pannexin hemichannels in brain glial cells: properties, pharmacology, and roles.

    Christian Giaume;Luc Leybaert;Christian Naus;Juan-Carlos Sáez

  • Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

    Jimmy Stehberg;Rodrigo Moraga-Amaro;Christian Salazar;Alvaro Becerra

  • Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

    Elke De Vuyst;Nan Wang;Elke Decrock;Marijke De Bock

  • Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

    Rainer Schulz;Philipp Maximilian Görge;Anikó Görbe;Péter Ferdinandy

  • Paracrine signaling through plasma membrane hemichannels.

    Nan Wang;Marijke De Bock;Elke Decrock;Mélissa Bol

  • The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

    Verónica Abudara;John Bechberger;Moises Freitas-Andrade;Marijke De Bock

  • Connexin hemichannels and gap junction channels are differentially influenced by lipopolysaccharide and basic fibroblast growth factor

    Elke De Vuyst;Elke Decrock;Marijke De Bock;Hiroshi Yamasaki

  • Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

    Luc Leybaert;Paul D. Lampe;Stefan Dhein;Brenda R. Kwak

  • Hunting for connexin hemichannels

    Juan C. Sáez;Luc Leybaert

  • Gap junctions and the propagation of cell survival and cell death signals.

    Dmitri Krysko;Luc Leybaert;Peter Vandenabeele;Katharina D'Herde

  • Mimetic peptides as blockers of connexin channel-facilitated intercellular communication.

    W Howard Evans;Luc Leybaert

  • Connexin 43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model.

    E. Decrock;E. De Vuyst;M. Vinken;M. Van Moorhem

Frequent Co-Authors

Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Vera Rogiers
Vera Rogiers Vrije Universiteit Brussel
Christian C. Naus
Christian C. Naus University of British Columbia
Dmitri V. Krysko
Dmitri V. Krysko Ghent University
Peter Vandenabeele
Peter Vandenabeele Ghent University
Jan B. Parys
Jan B. Parys KU Leuven
Christian Giaume
Christian Giaume Collège de France

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