2019 - Member of the National Academy of Sciences
Juan C. Sáez focuses on Gap junction, Connexin, Cell biology, Connexon and Neuroscience. His study in Gap junction is interdisciplinary in nature, drawing from both Molecular biology, Biophysics and Microglia. His studies in Connexin integrate themes in fields like Extracellular and Golgi apparatus.
His Cell biology study integrates concerns from other disciplines, such as Membrane channel and Cell type. The Connexon study combines topics in areas such as Purinergic receptor, Gating, Neuroglia and Membrane permeability. His study in the fields of Gliotransmitter under the domain of Neuroscience overlaps with other disciplines such as Amnesia.
His primary areas of study are Cell biology, Connexin, Gap junction, Pannexin and Intracellular. His research in Cell biology intersects with topics in Membrane permeability and Skeletal muscle. A large part of his Connexin studies is devoted to Connexon.
His research integrates issues of Astrocyte, Biophysics, Cell junction and Microglia in his study of Gap junction. Juan C. Sáez combines subjects such as Inflammation, Neurodegeneration, Receptor, Membrane channel and Programmed cell death with his study of Pannexin. His Intracellular study combines topics in areas such as Cell, Cell signaling, Calcium, Cell damage and Membrane potential.
His primary scientific interests are in Cell biology, Connexin, Intracellular, Gap junction and Pannexin. His Cell biology research is multidisciplinary, incorporating perspectives in Inflammation, Muscular dystrophy and Degranulation. Juan C. Sáez studies Connexin, focusing on Connexon in particular.
His Intracellular research also works with subjects such as
His main research concerns Cell biology, Connexin, Pannexin, Gap junction and Neuroscience. His Cell biology research incorporates themes from Membrane channel, Blockade and Immune system. His study with Connexin involves better knowledge in Intracellular.
His study in Pannexin is interdisciplinary in nature, drawing from both Myocyte, Purinergic receptor and Chagas disease. His study in Blood–brain barrier extends to Gap junction with its themes. His Astrocyte study, which is part of a larger body of work in Neuroscience, is frequently linked to Population, bridging the gap between disciplines.
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Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions
Juan C. Sáez;Viviana M. Berthoud;María C. Brañes;Agustín D. Martínez.
Physiological Reviews (2003)
Gap junctions: new tools, new answers, new questions.
M.V.L. Bennett;L.C. Barrio;T.A. Bargiello;D.C. Spray.
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions
Juan C. Saez;John A. Connor;David C. Spray;Michael V. L. Bennett.
Proceedings of the National Academy of Sciences of the United States of America (1989)
Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
Jorge E. Contreras;Helmut A. Sánchez;Eliseo A. Eugenín;Dina Speidel.
Proceedings of the National Academy of Sciences of the United States of America (2002)
Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.
Mauricio A. Retamal;Nicolas Froger;Nicolas Palacios-Prado;Pascal Ezan.
The Journal of Neuroscience (2007)
New roles for astrocytes: gap junction hemichannels have something to communicate
Michael V.L. Bennett;Jorge E. Contreras;Jorge E. Contreras;Feliksas F. Bukauskas;Juan C. Sáez;Juan C. Sáez.
Trends in Neurosciences (2003)
Connexin-based gap junction hemichannels: Gating mechanisms
Juan C. Sáez;Mauricio A. Retamal;Daniel Basilio;Feliksas F. Bukauskas.
Biochimica et Biophysica Acta (2005)
Gating and regulation of connexin 43 (Cx43) hemichannels
Jorge E. Contreras;Juan C. Sáez;Juan C. Sáez;Feliksas F. Bukauskas;Michael V. L. Bennett.
Proceedings of the National Academy of Sciences of the United States of America (2003)
cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide
Juan C. Saez;David C. Spray;Angus C. Nairn;Elliot Hertzberg.
Proceedings of the National Academy of Sciences of the United States of America (1986)
ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels
Juan A. Orellana;Nicolas Froger;Pascal Ezan;Jean X. Jiang.
Journal of Neurochemistry (2011)
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