Juan C. Sáez

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Chile Leader Award
• 2025 - Research.com Biology and Biochemistry in Chile Leader Award
• 2019 - Member of the National Academy of Sciences

Overview

Best Publications

• Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

  Juan C. Sáez;Viviana M. Berthoud;María C. Brañes;Agustín D. Martínez

  1432
  Citations

• Gap junctions: new tools, new answers, new questions.

  M.V.L. Bennett;L.C. Barrio;T.A. Bargiello;D.C. Spray

  1176
  Citations

• Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions

  Juan C. Saez;John A. Connor;David C. Spray;Michael V. L. Bennett

  723
  Citations

• Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

  Jorge E. Contreras;Helmut A. Sánchez;Eliseo A. Eugenín;Dina Speidel

  642
  Citations

• Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.

  Mauricio A. Retamal;Nicolas Froger;Nicolas Palacios-Prado;Pascal Ezan

  554
  Citations

• Gating and regulation of connexin 43 (Cx43) hemichannels

  Jorge E. Contreras;Juan C. Sáez;Juan C. Sáez;Feliksas F. Bukauskas;Michael V. L. Bennett

  528
  Citations

• Connexin-based gap junction hemichannels: Gating mechanisms

  Juan C. Sáez;Mauricio A. Retamal;Daniel Basilio;Feliksas F. Bukauskas

  494
  Citations

• New roles for astrocytes: gap junction hemichannels have something to communicate

  Michael V.L. Bennett;Jorge E. Contreras;Jorge E. Contreras;Feliksas F. Bukauskas;Juan C. Sáez;Juan C. Sáez

  483
  Citations

• cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide

  Juan C. Saez;David C. Spray;Angus C. Nairn;Elliot Hertzberg

  430
  Citations

• ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

  Juan A. Orellana;Nicolas Froger;Pascal Ezan;Jean X. Jiang

  430
  Citations

• S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents

  Mauricio A. Retamal;Constanza J. Cortés;Luis Reuss;Michael V. L. Bennett

  352
  Citations

• Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels

  Juan A. Orellana;Kenji F. Shoji;Verónica Abudara;Pascal Ezan

  336
  Citations

• Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue.

  Jorge E. Contreras;Helmuth A. Sánchez;Loreto P. Véliz;Feliksas F. Bukauskas

  307
  Citations

• Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

  A P Moreno;J C Sáez;G I Fishman;D C Spray

  305
  Citations

• Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-γ and tumor necrosis factor-α

  Eliseo A. Eugenín;Dominik Eckardt;Martin Theis;Klaus Willecke

  281
  Citations

• Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

  Juan A. Orellana;Pablo J. Sáez;Kenji F. Shoji;Kurt A. Schalper

  279
  Citations

• Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures.

  D C Spray;M Fujita;J C Saez;H Choi

  272
  Citations

• Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

  Jimmy Stehberg;Rodrigo Moraga-Amaro;Christian Salazar;Alvaro Becerra

  258
  Citations

• Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II

  Juan C. Saez;Angus C. Nairn;Andrew J. Czernik;David C. Spray

  252
  Citations

• TNF-α Plus IFN-γ Induce Connexin43 Expression and Formation of Gap Junctions Between Human Monocytes/Macrophages That Enhance Physiological Responses

  Eliseo A. Eugenín;Eliseo A. Eugenín;María C. Brañes;Joan W. Berman;Juan C. Sáez;Juan C. Sáez

  251
  Citations