D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 69 Citations 18,014 207 World Ranking 4649 National Ranking 4

Research.com Recognitions

Awards & Achievements

2019 - Member of the National Academy of Sciences

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Internal medicine
  • Biochemistry

Juan C. Sáez focuses on Gap junction, Connexin, Cell biology, Connexon and Neuroscience. His study in Gap junction is interdisciplinary in nature, drawing from both Molecular biology, Biophysics and Microglia. His studies in Connexin integrate themes in fields like Extracellular and Golgi apparatus.

His Cell biology study integrates concerns from other disciplines, such as Membrane channel and Cell type. The Connexon study combines topics in areas such as Purinergic receptor, Gating, Neuroglia and Membrane permeability. His study in the fields of Gliotransmitter under the domain of Neuroscience overlaps with other disciplines such as Amnesia.

His most cited work include:

  • Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions (938 citations)
  • Gap junctions: new tools, new answers, new questions. (861 citations)
  • Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions (521 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Connexin, Gap junction, Pannexin and Intracellular. His research in Cell biology intersects with topics in Membrane permeability and Skeletal muscle. A large part of his Connexin studies is devoted to Connexon.

His research integrates issues of Astrocyte, Biophysics, Cell junction and Microglia in his study of Gap junction. Juan C. Sáez combines subjects such as Inflammation, Neurodegeneration, Receptor, Membrane channel and Programmed cell death with his study of Pannexin. His Intracellular study combines topics in areas such as Cell, Cell signaling, Calcium, Cell damage and Membrane potential.

He most often published in these fields:

  • Cell biology (90.07%)
  • Connexin (83.56%)
  • Gap junction (76.37%)

What were the highlights of his more recent work (between 2017-2021)?

  • Cell biology (90.07%)
  • Connexin (83.56%)
  • Intracellular (35.27%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Cell biology, Connexin, Intracellular, Gap junction and Pannexin. His Cell biology research is multidisciplinary, incorporating perspectives in Inflammation, Muscular dystrophy and Degranulation. Juan C. Sáez studies Connexin, focusing on Connexon in particular.

His Intracellular research also works with subjects such as

  • Skeletal muscle most often made with reference to Membrane permeability,
  • Cell culture, Cell damage and Pharmacology most often made with reference to Nitric oxide. Juan C. Sáez has included themes like Pineal gland, Adrenergic receptor, Glycogen, HeLa and Cell type in his Gap junction study. His Pannexin research is multidisciplinary, incorporating elements of Neurodegeneration, Protein phosphorylation, Innexin and Protein kinase C, Phosphorylation.

Between 2017 and 2021, his most popular works were:

  • Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function. (20 citations)
  • Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function. (20 citations)
  • Connexins and pannexins in Alzheimer's disease (20 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Internal medicine
  • Biochemistry

His main research concerns Cell biology, Connexin, Pannexin, Gap junction and Neuroscience. His Cell biology research incorporates themes from Membrane channel, Blockade and Immune system. His study with Connexin involves better knowledge in Intracellular.

His study in Pannexin is interdisciplinary in nature, drawing from both Myocyte, Purinergic receptor and Chagas disease. His study in Blood–brain barrier extends to Gap junction with its themes. His Astrocyte study, which is part of a larger body of work in Neuroscience, is frequently linked to Population, bridging the gap between disciplines.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

Juan C. Sáez;Viviana M. Berthoud;María C. Brañes;Agustín D. Martínez.
Physiological Reviews (2003)

1290 Citations

Gap junctions: new tools, new answers, new questions.

M.V.L. Bennett;L.C. Barrio;T.A. Bargiello;D.C. Spray.
Neuron (1991)

1166 Citations

Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions

Juan C. Saez;John A. Connor;David C. Spray;Michael V. L. Bennett.
Proceedings of the National Academy of Sciences of the United States of America (1989)

690 Citations

Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

Jorge E. Contreras;Helmut A. Sánchez;Eliseo A. Eugenín;Dina Speidel.
Proceedings of the National Academy of Sciences of the United States of America (2002)

591 Citations

Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.

Mauricio A. Retamal;Nicolas Froger;Nicolas Palacios-Prado;Pascal Ezan.
The Journal of Neuroscience (2007)

483 Citations

New roles for astrocytes: gap junction hemichannels have something to communicate

Michael V.L. Bennett;Jorge E. Contreras;Jorge E. Contreras;Feliksas F. Bukauskas;Juan C. Sáez;Juan C. Sáez.
Trends in Neurosciences (2003)

446 Citations

Connexin-based gap junction hemichannels: Gating mechanisms

Juan C. Sáez;Mauricio A. Retamal;Daniel Basilio;Feliksas F. Bukauskas.
Biochimica et Biophysica Acta (2005)

442 Citations

Gating and regulation of connexin 43 (Cx43) hemichannels

Jorge E. Contreras;Juan C. Sáez;Juan C. Sáez;Feliksas F. Bukauskas;Michael V. L. Bennett.
Proceedings of the National Academy of Sciences of the United States of America (2003)

424 Citations

cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide

Juan C. Saez;David C. Spray;Angus C. Nairn;Elliot Hertzberg.
Proceedings of the National Academy of Sciences of the United States of America (1986)

415 Citations

ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

Juan A. Orellana;Nicolas Froger;Pascal Ezan;Jean X. Jiang.
Journal of Neurochemistry (2011)

368 Citations

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