Juan C. Sáez

Juan C. Sáez publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Juan C. Sáez sits on this spectrum.

Juan C. Sáez D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Juan C. Sáez sits on this spectrum.

Research.com Recognitions

• 2026 - Research.com Biology and Biochemistry in Chile Leader Award
• 2025 - Research.com Biology and Biochemistry in Chile Leader Award
• 2019 - Member of the National Academy of Sciences

Overview

Best Publications

• Plasma Membrane Channels Formed by Connexins: Their Regulation and Functions

  Juan C. Sáez;Viviana M. Berthoud;María C. Brañes;Agustín D. Martínez

  1432
  Citations

• Gap junctions: new tools, new answers, new questions.

  M.V.L. Bennett;L.C. Barrio;T.A. Bargiello;D.C. Spray

  1176
  Citations

• Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions

  Juan C. Saez;John A. Connor;David C. Spray;Michael V. L. Bennett

  723
  Citations

• Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture

  Jorge E. Contreras;Helmut A. Sánchez;Eliseo A. Eugenín;Dina Speidel

  642
  Citations

• Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia.

  Mauricio A. Retamal;Nicolas Froger;Nicolas Palacios-Prado;Pascal Ezan

  554
  Citations

• Gating and regulation of connexin 43 (Cx43) hemichannels

  Jorge E. Contreras;Juan C. Sáez;Juan C. Sáez;Feliksas F. Bukauskas;Michael V. L. Bennett

  528
  Citations

• Connexin-based gap junction hemichannels: Gating mechanisms

  Juan C. Sáez;Mauricio A. Retamal;Daniel Basilio;Feliksas F. Bukauskas

  494
  Citations

• New roles for astrocytes: gap junction hemichannels have something to communicate

  Michael V.L. Bennett;Jorge E. Contreras;Jorge E. Contreras;Feliksas F. Bukauskas;Juan C. Sáez;Juan C. Sáez

  483
  Citations

• cAMP increases junctional conductance and stimulates phosphorylation of the 27-kDa principal gap junction polypeptide

  Juan C. Saez;David C. Spray;Angus C. Nairn;Elliot Hertzberg

  430
  Citations

• ATP and glutamate released via astroglial connexin 43 hemichannels mediate neuronal death through activation of pannexin 1 hemichannels

  Juan A. Orellana;Nicolas Froger;Pascal Ezan;Jean X. Jiang

  430
  Citations

• S-nitrosylation and permeation through connexin 43 hemichannels in astrocytes: Induction by oxidant stress and reversal by reducing agents

  Mauricio A. Retamal;Constanza J. Cortés;Luis Reuss;Michael V. L. Bennett

  352
  Citations

• Amyloid β-Induced Death in Neurons Involves Glial and Neuronal Hemichannels

  Juan A. Orellana;Kenji F. Shoji;Verónica Abudara;Pascal Ezan

  336
  Citations

• Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue.

  Jorge E. Contreras;Helmuth A. Sánchez;Loreto P. Véliz;Feliksas F. Bukauskas

  307
  Citations

• Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation.

  A P Moreno;J C Sáez;G I Fishman;D C Spray

  305
  Citations

• Microglia at brain stab wounds express connexin 43 and in vitro form functional gap junctions after treatment with interferon-γ and tumor necrosis factor-α

  Eliseo A. Eugenín;Dominik Eckardt;Martin Theis;Klaus Willecke

  281
  Citations

• Modulation of Brain Hemichannels and Gap Junction Channels by Pro-Inflammatory Agents and Their Possible Role in Neurodegeneration

  Juan A. Orellana;Pablo J. Sáez;Kenji F. Shoji;Kurt A. Schalper

  279
  Citations

• Proteoglycans and glycosaminoglycans induce gap junction synthesis and function in primary liver cultures.

  D C Spray;M Fujita;J C Saez;H Choi

  272
  Citations

• Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

  Jimmy Stehberg;Rodrigo Moraga-Amaro;Christian Salazar;Alvaro Becerra

  258
  Citations

• Phosphorylation of connexin 32, a hepatocyte gap-junction protein, by cAMP-dependent protein kinase, protein kinase C and Ca2+/calmodulin-dependent protein kinase II

  Juan C. Saez;Angus C. Nairn;Andrew J. Czernik;David C. Spray

  252
  Citations

• TNF-α Plus IFN-γ Induce Connexin43 Expression and Formation of Gap Junctions Between Human Monocytes/Macrophages That Enhance Physiological Responses

  Eliseo A. Eugenín;Eliseo A. Eugenín;María C. Brañes;Joan W. Berman;Juan C. Sáez;Juan C. Sáez

  251
  Citations