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Biology and Biochemistry

D-Index
65
Citations
15708
World Ranking
9125
National Ranking
4051

Overview

Paul D. Lampe is affiliated with the Fred Hutchinson Cancer Research Center in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a strong emphasis on Molecular Biology, Oncology, Pulmonary and Respiratory Medicine, Radiology, Nuclear Medicine and Imaging, and Physiology.

The scientist's work covers multiple topics, including:

  • Connexins and lens biology
  • Lung Cancer Research Studies
  • Lung Cancer Diagnosis and Treatment
  • Nicotinic Acetylcholine Receptors Study
  • Peptidase Inhibition and Analysis
  • Cancer Immunotherapy and Biomarkers
  • Diet and metabolism studies

Recent publications reflect diverse focal points in cellular and cancer biology. Notable papers include:

  • Embryo-scale, single-cell spatial transcriptomics, 2021, Science
  • Prevention of connexin-43 remodeling protects against Duchenne muscular dystrophy cardiomyopathy, 2020, Journal of Clinical Investigation
  • Auxiliary trafficking subunit GJA1-20k protects connexin-43 from degradation and limits ventricular arrhythmias, 2020, Journal of Clinical Investigation
  • Cellular mechanisms of connexin-based inherited diseases, 2021, Trends in Cell Biology
  • Biomarkers for Early Detection of Colorectal Cancer: The Early Detection Research Network, a Framework for Clinical Translation, 2020, Cancer Epidemiology Biomarkers & Prevention

Frequently published venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Thoracic Oncology
  • Journal of Clinical Investigation
  • Biomolecules
  • Cancers

Collaborations form a significant component of their research output. Frequent co-authors are:

  • A. McGarry Houghton
  • Kristin J. Lastwika
  • Joell L. Solan
  • Paul E. Kinahan
  • Timothy W. Randolph

Best Publications

  • Selective transfer of endogenous metabolites through gap junctions composed of different connexins.

    Gary S. Goldberg;Paul D. Lampe;Bruce J. Nicholson

  • Gap junctions and cancer: communicating for 50 years

    Trond Aasen;Marc Mesnil;Christian C. Naus;Paul D. Lampe

  • Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: One of two paths to meiotic resumption

    Rachael P. Norris;Marina Freudzon;Lisa M. Mehlmann;Ann E. Cowan

  • Trafficking, assembly, and function of a connexin43-green fluorescent protein chimera in live mammalian cells.

    Karen Jordan;Joell L. Solan;Michel Dominguez;Michael Sia

  • Cellular Interaction of Integrin α3β1 with Laminin 5 Promotes Gap Junctional Communication

    Paul D Lampe;Paul D Lampe;Beth P. Nguyen;Beth P. Nguyen;Susana María Gil;Marcia L. Usui

  • Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

    Rainer Schulz;Philipp Maximilian Görge;Anikó Görbe;Péter Ferdinandy

  • Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications

    Luc Leybaert;Paul D. Lampe;Stefan Dhein;Brenda R. Kwak

  • Analysis of Connexin43 phosphorylated at S325, S328 and S330 in normoxic and ischemic heart.

    Paul D. Lampe;Cynthia D. Cooper;Timothy J. King;Janis M. Burt

  • Key connexin 43 phosphorylation events regulate the gap junction life cycle.

    Joell L. Solan;Paul D. Lampe

  • Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation.

    Joell L. Solan;Matthew D. Fry;Erica M. TenBroek;Paul D. Lampe

  • Embryo-scale, single-cell spatial transcriptomics.

    Sanjay R. Srivatsan;Mary C. Regier;Eliza Barkan;Jennifer M. Franks

  • Phosphorylation at S365 is a gatekeeper event that changes the structure of Cx43 and prevents down-regulation by PKC

    Joell L. Solan;Lucrecia Marquez-Rosado;Paul L. Sorgen;Perry J. Thornton

  • FORMATION OF A DISTINCT CONNEXIN43 PHOSPHOISOFORM IN MITOTIC CELLS IS DEPENDENT UPON P34CDC2 KINASE

    Paul D. Lampe;Wendy E. Kurata;Bonnie J. Warn-Cramer;Alan F. Lau

  • Therapeutic strategies targeting connexins

    Dale W. Laird;Paul D. Lampe

  • Injury-triggered Akt phosphorylation of Cx43: a ZO-1-driven molecular switch that regulates gap junction size

    Clarence A. Dunn;Paul D. Lampe

  • Regulation of connexin43 function by activated tyrosine protein kinases.

    Alan F. Lau;Wendy E. Kurata;Martha Y. Kanemitsu;Lenora W. M. Loo

  • Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles

    Leia C. Shuhaibar;Jeremy R. Egbert;Rachael P. Norris;Paul D. Lampe

  • Connexin43 phosphorylation in brain, cardiac, endothelial and epithelial tissues.

    Lucrecia Márquez-Rosado;Joell L. Solan;Clarence A. Dunn;Rachael P. Norris

  • Connexin 43 interacts with zona occludens-1 and -2 proteins in a cell cycle stage-specific manner.

    Deepika Singh;Deepika Singh;Joell L. Solan;Joell L. Solan;Steven M. Taffet;Ronald Javier

  • Protein kinase C spatially and temporally regulates gap junctional communication during human wound repair via phosphorylation of connexin43 on serine368.

    Theresa S. Richards;Theresa S. Richards;Clarence A. Dunn;Clarence A. Dunn;William G. Carter;William G. Carter;Marcia L. Usui

Frequent Co-Authors

Johanna W. Lampe
Johanna W. Lampe Fred Hutchinson Cancer Research Center
Christopher I. Li
Christopher I. Li Fred Hutchinson Cancer Research Center
Daniel Raftery
Daniel Raftery University of Washington
John D. Potter
John D. Potter Massey University
Dale W. Laird
Dale W. Laird University of Western Ontario
Yutaka Yasui
Yutaka Yasui St. Jude Children's Research Hospital
Samir M. Hanash
Samir M. Hanash The University of Texas MD Anderson Cancer Center
Paul E. Kinahan
Paul E. Kinahan University of Washington
Christian C. Naus
Christian C. Naus University of British Columbia
Marian L. Neuhouser
Marian L. Neuhouser Fred Hutchinson Cancer Research Center

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