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Geert Bultynck

Geert Bultynck

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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
82
Citations
48411
World Ranking
3606
National Ranking
60

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Geert Bultynck is affiliated with KU Leuven in Belgium and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a substantial focus on medicine. Their research portfolio includes 149 publications in these primary fields, covering a variety of subfields such as molecular biology, cell biology, physiology, cellular and molecular neuroscience, and immunology.

The main topics of Bultynck's research encompass mitochondrial function and pathology, cell death mechanisms and regulation, ion channel regulation and function, endoplasmic reticulum stress and disease, neuroscience and neuropharmacology research, ATP synthase and ATPases research, and autophagy in disease and therapy.

Recent papers that highlight their research scope include:

  • "Necroptosis in Immuno-Oncology and Cancer Immunotherapy," 2020, published in Cells
  • "Pore-forming proteins as drivers of membrane permeabilization in cell death pathways," 2022, published in Nature Reviews Molecular Cell Biology
  • "Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease," 2021, published in Trends in Cell Biology
  • "The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy," 2025, published in Signal Transduction and Targeted Therapy
  • "Cx43 hemichannel microdomain signaling at the intercalated disc enhances cardiac excitability," 2021, published in the Journal of Clinical Investigation

Bultynck often collaborates with frequent co-authors, including Jan B. Parys, Tim Vervliet, Martijn Kerkhofs, Rita La Rovere, and Jens Loncke. Their joint publications demonstrate a collaborative research network contributing to overlapping areas of cellular and molecular biology.

Publication venues where Bultynck has frequently published include:

  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
  • Cell Calcium
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Death and Disease
  • Cells

The scientist's work is situated at the intersection of molecular and cellular mechanisms underpinning health and disease, with a particular research emphasis on intracellular signaling pathways, ion channel functions, and mechanisms regulating programmed cell death. The thematic concentration on mitochondrial and endoplasmic reticulum functions, as well as associated pathology, forms a consistent thread throughout their publication record.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

    Verfaillie T;Rubio N;Rubio N;Garg Ad;Bultynck G

  • Endoplasmic-Reticulum Calcium Depletion and Disease

    Djalila Mekahli;Geert Bultynck;Jan B. Parys;Humbert De Smedt

  • The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

    Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong

  • Calcium Signaling in Cardiac Myocytes

    Claire J. Fearnley;H. Llewelyn Roderick;Martin D. Bootman

  • A dual role for Ca(2+) in autophagy regulation.

    Jean-Paul Decuypere;Geert Bultynck;Jan B. Parys

  • Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

    Nan Wang;Elke De Vuyst;Raf Ponsaerts;Kerstin Boengler

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

    Yi Ping Rong;Ademuyiwa S. Aromolaran;Geert Bultynck;Fei Zhong

  • The regulation of autophagy by calcium signals: Do we have a consensus?

    Martin D. Bootman;Tala Chehab;Geert Bultynck;Jan B. Parys

  • Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy.

    Rita M.L. La Rovere;Gemma Roest;Geert Bultynck;Jan B. Parys

  • Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala

    Jimmy Stehberg;Rodrigo Moraga-Amaro;Christian Salazar;Alvaro Becerra

  • Regulation of the autophagic bcl-2/beclin 1 interaction.

    Jean-Paul Decuypere;Jan B. Parys;Geert Bultynck

  • A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

    Haidar Akl;Tamara Vervloessem;Santeri Kiviluoto;Mart Bittremieux

  • HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

    Steve Stegen;Kjell Laperre;Guy Eelen;Gianmarco Rinaldi

  • Paracrine signaling through plasma membrane hemichannels.

    Nan Wang;Marijke De Bock;Elke Decrock;Mélissa Bol

  • The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes

    Verónica Abudara;John Bechberger;Moises Freitas-Andrade;Marijke De Bock

Frequent Co-Authors

Jan B. Parys
Jan B. Parys KU Leuven
Luc Leybaert
Luc Leybaert Ghent University
Martin D. Bootman
Martin D. Bootman The Open University
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
Mathieu Vinken
Mathieu Vinken Vrije Universiteit Brussel
Dmitri V. Krysko
Dmitri V. Krysko Ghent University

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