World's Best Scientists 2026 revealed!
Jan B. Parys

Jan B. Parys

Award Badge
Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
54112
World Ranking
3056
National Ranking
48

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award

Overview

Jan B. Parys is a researcher affiliated with KU Leuven in Belgium, with a focus on the intersection of biochemistry, genetics, molecular biology, and medicine. Their scholarly output spans various subfields including molecular biology, physiology, cell biology, cellular and molecular neuroscience, and sensory systems. The main scientific topics that characterize their work are:

  • Ion channel regulation and function
  • Mitochondrial function and pathology
  • Endoplasmic reticulum stress and disease
  • ATP synthase and ATPases research
  • Cell death mechanisms and regulation
  • Calcium signaling and nucleotide metabolism
  • Neuroscience and neuropharmacology research

Their publication record features papers in notable journals, often with a focus on cellular calcium dynamics and its role in health and disease. Recent publications include:

  • "Necroptosis in Immuno-Oncology and Cancer Immunotherapy" (2020, Cells)
  • "Balancing ER-Mitochondrial Ca2+ Fluxes in Health and Disease" (2021, Trends in Cell Biology)
  • "Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis" (2021, Cell Death and Differentiation)
  • "A comprehensive overview of the complex world of the endo- and sarcoplasmic reticulum Ca2+-leak channels" (2021, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research)
  • "TRPC3 shapes the ER-mitochondria Ca2+ transfer characterizing tumour-promoting senescence" (2022, Nature Communications)

Jan B. Parys collaborates frequently with several researchers, enhancing their work through interdisciplinary approaches. Regular co-authors include:

  • Geert Bultynck
  • Fernanda O. Lemos
  • Martijn Kerkhofs
  • Ian de Ridder
  • Jens Loncke

Their studies have been published repeatedly in journals such as Cell Calcium, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Cells, International Journal of Molecular Sciences, and Trends in Cell Biology. These venues reflect the focus on cell signaling and molecular mechanisms underlying cellular physiology and pathology.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Control of inositol 1,4,5-trisphosphate-induced Ca2+ release by cytosolic Ca2+.

    M D Bootman;L Missiaen;J B Parys;H De Smedt

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Endoplasmic-Reticulum Calcium Depletion and Disease

    Djalila Mekahli;Geert Bultynck;Jan B. Parys;Humbert De Smedt

  • Functional specialization of calreticulin domains.

    Kimitoshi Nakamura;Anna Zuppini;Serge Arnaudeau;Jeffery Lynch

  • The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

    Yi Ping Rong;Geert Bultynck;Ademuyiwa S. Aromolaran;Fei Zhong

  • Calcium Signaling in Cardiac Myocytes

    Claire J. Fearnley;H. Llewelyn Roderick;Martin D. Bootman

  • Isolation, characterization, and localization of the inositol 1,4,5-trisphosphate receptor protein in Xenopus laevis oocytes.

    Jan B. Parys;Suzanne W. Sernett;Sylvain DeLisle;Peter M. Snyder

  • A dual role for Ca(2+) in autophagy regulation.

    Jean-Paul Decuypere;Geert Bultynck;Jan B. Parys

  • Abnormal intracellular ca(2+)homeostasis and disease.

    L. Missiaen;W. Robberecht;L.Van Den Bosch;G. Callewaert

  • Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis.

    Tania Szado;Veerle Vanderheyden;Jan B. Parys;Humbert De Smedt

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

    Yi Ping Rong;Ademuyiwa S. Aromolaran;Geert Bultynck;Fei Zhong

  • The regulation of autophagy by calcium signals: Do we have a consensus?

    Martin D. Bootman;Tala Chehab;Geert Bultynck;Jan B. Parys

  • Intracellular Ca(2+) signaling and Ca(2+) microdomains in the control of cell survival, apoptosis and autophagy.

    Rita M.L. La Rovere;Gemma Roest;Geert Bultynck;Jan B. Parys

  • Subcellular distribution of the inositol 1,4,5-trisphosphate receptors: functional relevance and molecular determinants

    Elke Vermassen;Jan B. Parys;Jean-Pierre Mauger

  • 2-Aminoethoxydiphenyl borate affects the inositol 1,4,5-trisphosphate receptor, the intracellular Ca2+pump and the non-specific Ca2+leak from the non-mitochondrial Ca2+stores in permeabilized A7r5 cells

    L. Missiaen;G. Callewaert;H. De Smedt;J.B. Parys

  • A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

    Haidar Akl;Tamara Vervloessem;Santeri Kiviluoto;Mart Bittremieux

Frequent Co-Authors

Rik Casteels
Rik Casteels KU Leuven
Martin D. Bootman
Martin D. Bootman The Open University
Rafael A. Fissore
Rafael A. Fissore University of Massachusetts Amherst
Frank Wuytack
Frank Wuytack KU Leuven
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
Luc Leybaert
Luc Leybaert Ghent University

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Best Scientists Citing Jan B. Parys

Trending Scientists