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Biology and Biochemistry

D-Index
65
Citations
13000
World Ranking
9295
National Ranking
4103

Overview

David I. Yule is affiliated with the University of Rochester in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology as well as Medicine. Within these broader areas, Yule has contributed extensively to Molecular Biology, Physiology, Sensory Systems, Cellular and Molecular Neuroscience, and Cell Biology.

The scientist's work concentrates on key topics including Ion channel regulation and function, Ion Channels and Receptors, Calcium signaling and nucleotide metabolism, Protein Kinase Regulation and GTPase Signaling, Salivary Gland Disorders and Functions, Neurobiology and Insect Physiology Research, and Lipid Membrane Structure and Behavior.

Frequent collaborators of David I. Yule include Larry E. Wagner, Vikas Arige, James Sneyd, Lara E. Terry, and Takahiro Takano, reflecting ongoing partnerships in their research endeavors.

Yule has published notably in venues such as bioRxiv (Cold Spring Harbor Laboratory) with 16 papers, Cell Calcium and The Journal of Physiology each hosting 7 publications, Journal of Biological Chemistry with 5, and Nature Communications with 4 works.

Among recent papers are the following:

  • "The native ORAI channel trio underlies the diversity of Ca2+ signaling events" (2020, Nature Communications)
  • "Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling" (2021, Cell Reports)
  • "Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis" (2021, Cell Death and Differentiation)
  • "The volume-regulated anion channel LRRC8C suppresses T cell function by regulating cyclic dinucleotide transport and STING-p53 signaling" (2022, Nature Immunology)
  • "Capture at the ER-mitochondrial contacts licenses IP3 receptors to stimulate local Ca2+ transfer and oxidative metabolism" (2022, Nature Communications)

Best Publications

  • Calcium and mitochondria

    Thomas E. Gunter;David I. Yule;Karlene K. Gunter;Roman A. Eliseev

  • Regulation of fluid and electrolyte secretion in salivary gland acinar cells.

    James E. Melvin;David Yule;Trevor Shuttleworth;Ted Begenisich

  • Cytoplasmic Ca2+ oscillations evoked by receptor stimulation, G-protein activation, internal application of inositol trisphosphate or Ca2+: simultaneous microfluorimetry and Ca2+ dependent Cl- current recording in single pancreatic acinar cells.

    Y.V. Osipchuk;M. Wakui;D.I. Yule;D.V. Gallacher

  • U73122 inhibits Ca2+ oscillations in response to cholecystokinin and carbachol but not to JMV-180 in rat pancreatic acinar cells.

    David I. Yule;John A. Williams

  • Identification of a Ryanodine Receptor in Rat Heart Mitochondria

    Gisela Beutner;Virendra K. Sharma;David R. Giovannucci;David I. Yule

  • IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer.

    Adam Bartok;Adam Bartok;David Weaver;Tünde Golenár;Zuzana Nichtova

  • Evidence that zymogen granules are not a physiologically relevant calcium pool. Defining the distribution of inositol 1,4,5-trisphosphate receptors in pancreatic acinar cells.

    David I. Yule;Stephen A. Ernst;Hirohide Ohnishi;Richard J.H. Wojcikiewicz

  • Calcium wave propagation in pancreatic acinar cells: functional interaction of inositol 1,4,5-trisphosphate receptors, ryanodine receptors, and mitochondria.

    Stephen V. Straub;David R. Giovannucci;David I. Yule

  • Stimulus-secretion coupling in pancreatic acinar cells.

    Daniel B. Burnham;John A. Williams

  • Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling.

    Jason I.E. Bruce;Trevor J. Shuttleworth;David R. Giovannucci;David I. Yule

  • Defining the stoichiometry of inositol 1,4,5-trisphosphate binding required to initiate Ca2+ release

    Kamil J. Alzayady;Liwei Wang;Rahul Chandrasekhar;Larry E. Wagner

  • Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.

    Jason I.E Bruce;Stephen V Straub;David I Yule

  • Control of calcium oscillations by membrane fluxes

    J Sneyd;KT Tsaneva-Atanasova;DI Yule;JL Thompson

  • Akt Kinase Phosphorylation of Inositol 1,4,5-Trisphosphate Receptors *

    M. Tariq Khan;Larry Wagner;David I. Yule;Cunnigaiper Bhanumathy

  • Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.

    Lianghui Zhang;Sundeep Malik;Jinjiang Pang;Huan Wang

  • Phosphorylation of type-1 inositol 1,4,5-trisphosphate receptors by cyclic nucleotide-dependent protein kinases: a mutational analysis of the functionally important sites in the S2+ and S2- splice variants.

    Larry E. Wagner;Wen Hong Li;David I. Yule

  • Isoform- and Species-specific Control of Inositol 1,4,5-Trisphosphate (IP3) Receptors by Reactive Oxygen Species

    Száva Bánsághi;Tünde Golenár;Muniswamy Madesh;György Csordás

  • Oscillations of cytosolic calcium in single pancreatic acinar cells stimulated by acetylcholine

    D.I. Yule;D.V. Gallacher

  • Recessive and Dominant De Novo ITPR1 Mutations Cause Gillespie Syndrome

    Sylvie Gerber;Kamil J. Alzayady;Lydie Burglen;Dominique Brémond-Gignac

  • Agonist-dependent phosphorylation of the inositol 1,4,5-trisphosphate receptor: A possible mechanism for agonist-specific calcium oscillations in pancreatic acinar cells.

    Andrew P. LeBeau;David I. Yule;Guy E. Groblewski;James Sneyd

Frequent Co-Authors

John A. Williams
John A. Williams University of Michigan–Ann Arbor
Suresh K. Joseph
Suresh K. Joseph Thomas Jefferson University
Edmund J. Crampin
Edmund J. Crampin University of Melbourne
Ole H. Petersen
Ole H. Petersen Cardiff University
Jan B. Parys
Jan B. Parys KU Leuven
Katsuhiko Mikoshiba
Katsuhiko Mikoshiba ShanghaiTech University
György Hajnóczky
György Hajnóczky Thomas Jefferson University
William J. Bowers
William J. Bowers University of Rochester
Stephen A. Ernst
Stephen A. Ernst University of Michigan–Ann Arbor

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