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Biology and Biochemistry

D-Index
69
Citations
25043
World Ranking
7261
National Ranking
555

Overview

Alexei V. Tepikin is affiliated with the University of Liverpool in the United Kingdom. Their research is primarily focused in the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific contributions to Surgery, Physiology, Epidemiology, Molecular Biology, and Sensory Systems.

The scientist has authored multiple papers that explore various aspects of pancreatic function, calcium signaling, and autophagy. Notable recent publications include:

  • Deletion of the WD40 domain of ATG16L1 exacerbates acute pancreatitis, abolishes LAP-like non-canonical autophagy and slows trypsin degradation, 2024, Autophagy
  • Autophagy, Acute Pancreatitis and the Metamorphoses of a Trypsinogen-Activating Organelle, 2022, Cells
  • Protective Effects of Necrostatin-1 in Acute Pancreatitis: Partial Involvement of Receptor Interacting Protein Kinase 1, 2021, Cells
  • Knockout of the Mitochondrial Calcium Uniporter Strongly Suppresses Stimulus-Metabolism Coupling in Pancreatic Acinar Cells but Does Not Reduce Severity of Experimental Acute Pancreatitis, 2020, Cells
  • The role of Ca2+ signalling in the physiology and pathophysiology of exocrine pancreas, 2020, Current Opinion in Physiology

They have frequently collaborated with researchers such as David N. Criddle, Michael Chvanov, Svetlana Voronina, Robert Sutton, and Diane Latawiec.

The venues where their work has most often appeared include:

  • Cells
  • Cell Calcium
  • Autophagy
  • British Journal of Surgery
  • Current Opinion in Physiology

The primary topics of Tepikin's research cover:

  • Pancreatitis Pathology and Treatment
  • Pancreatic function and diabetes
  • Liver Disease Diagnosis and Treatment
  • Ion Channels and Receptors
  • Calcium signaling and nucleotide metabolism
  • Lysosomal Storage Disorders Research
  • Autophagy in Disease and Therapy

This collective work details investigations into the pathology of pancreatitis, mechanisms of calcium signaling in pancreatic cells, and the role of autophagy in disease processes. The research extends to molecular and cellular physiology relevant to exocrine pancreas function and related metabolic coupling mechanisms.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • ATP-DEPENDENT ACCUMULATION AND INOSITOL TRISPHOSPHATE- OR CYCLIC ADP-RIBOSE-MEDIATED RELEASE OF CA2+ FROM THE NUCLEAR ENVELOPE

    Oleg V Gerasimenko;Julia V Gerasimenko;Alexei V Tepikin;Ole H Petersen

  • Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate-evoked local cytosolic Ca2+ signals

    Hanna Tinel;Jose M. Cancela;Hideo Mogami;Julia V. Gerasimenko

  • Menadione-induced reactive oxygen species generation via redox cycling promotes apoptosis of murine pancreatic acinar cells.

    Dabid N. Criddle;Stuart Gillies;Heidi K. Baumgartner-Wilson;Mohammed Jaffar;Mohammed Jaffar

  • Perinuclear, perigranular and sub‐plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport

    Myoung Kyu Park;Michael C. Ashby;Gul Erdemli;Ole Holger Petersen

  • Polarized Calcium Signaling in Exocrine Gland Cells

    Ole H Petersen;Alexei V Tepikin

  • Calcium uptake via endocytosis with rapid release from acidifying endosomes

    Julia V. Gerasimenko;Alexei V. Tepikin;Ole H. Petersen;Oleg V. Gerasimenko

  • Fatty Acid Ethyl Esters Cause Pancreatic Calcium Toxicity via Inositol Trisphosphate Receptors and Loss of ATP Synthesis

    David N. Criddle;John Murphy;Gregorio Fistetto;Stephanie Barrow

  • Ca2+ flow via tunnels in polarized cells: recharging of apical Ca2+ stores by focal Ca2+ entry through basal membrane patch.

    Hideo Mogami;Kyoko Nakano;Alexei V Tepikin;Ole H Petersen

  • Calcium Elevation in Mitochondria Is the Main Ca2+ Requirement for Mitochondrial Permeability Transition Pore (mPTP) Opening

    Heidi K. Baumgartner;Julia V. Gerasimenko;Christopher Thorne;Pawel Ferdek

  • Termination of cytosolic Ca2+ signals: Ca2+ reuptake into intracellular stores is regulated by the free Ca2+ concentration in the store lumen.

    Hideo Mogami;Alexei V. Tepikin;Ole H. Petersen

  • The endoplasmic reticulum as one continuous Ca2+ pool: visualization of rapid Ca2+ movements and equilibration

    Myoung Kyu Park;Ole Holger Petersen;Alexei V. Tepikin

  • Two different but converging messenger pathways to intracellular Ca2+ release: the roles of nicotinic acid adenine dinucleotide phosphate, cyclic ADP-ribose and inositol trisphosphate

    Jose Manuel Cancela;Oleg Vsevolodovich Gerasimenko;Julia Vladimirovna Gerasimenko;Alexei Tepikin

  • NAADP mobilizes Ca2+ from a thapsigargin-sensitive store in the nuclear envelope by activating ryanodine receptors

    Julia Vladimirovna Gerasimenko;Yoshio Maruyama;Kojiro Yano;Nick J. Dolman

  • Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function

    Robert D Burgoyne;Dermott W O'Callaghan;Burcu Hasdemir;Lee P Haynes

  • Ethanol toxicity in pancreatic acinar cells: Mediation by nonoxidative fatty acid metabolites

    David N. Criddle;Michael G. T. Raraty;John P. Neoptolemos;Alexei V. Tepikin

  • Calcium leak from intracellular stores-the enigma of calcium signalling

    C. Camello;R. Lomax;Ole Holger Petersen;A. V. Tepikin

  • Transformation of local Ca2+ spikes to global Ca2+ transients: the combinatorial roles of multiple Ca2+ releasing messengers

    Jose M. Cancela;Fabien Van Coppenolle;Antony Galione;Alexei V. Tepikin

  • Mechanism of mitochondrial permeability transition pore induction and damage in the pancreas: inhibition prevents acute pancreatitis by protecting production of ATP

    Rajarshi Mukherjee;Rajarshi Mukherjee;Olga A Mareninova;Irina V Odinokova;Irina V Odinokova;Wei Huang;Wei Huang;Wei Huang

  • Reactive Oxygen Species Induced by Bile Acid Induce Apoptosis and Protect Against Necrosis in Pancreatic Acinar Cells

    David Booth;David Booth;John Murphy;John Murphy;Rajarshi Mukherjee;Rajarshi Mukherjee;Muhammad Awais

Frequent Co-Authors

Ole H. Petersen
Ole H. Petersen Cardiff University
Robert Sutton
Robert Sutton University of Liverpool
John P. Neoptolemos
John P. Neoptolemos Heidelberg University
Li Wen
Li Wen Yale University
Muhammad Awais
Muhammad Awais University of Surrey
Robert D. Burgoyne
Robert D. Burgoyne University of Liverpool
P. G. Kostyuk
P. G. Kostyuk National Academy of Sciences of Ukraine
Ian A. Prior
Ian A. Prior University of Liverpool
Rajesh Gupta
Rajesh Gupta University of California, San Diego

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