Li Wen spends much of his time researching Immunology, NOD mice, Internal medicine, Type 1 diabetes and Endocrinology. His study involves Immune system, Autoantibody, Insulitis, Autoimmunity and Gut flora, a branch of Immunology. His study with NOD mice involves better knowledge in Nod.
His Internal medicine research is multidisciplinary, incorporating perspectives in Autophagy and Aldose reductase. Li Wen works mostly in the field of Type 1 diabetes, limiting it down to topics relating to CD8 and, in certain cases, MHC class II, Cytokine and Molecular biology. His Endocrinology study incorporates themes from Thapsigargin, Acute pancreatitis, Store-operated calcium entry and Pancreatitis.
Li Wen mainly investigates Immunology, NOD mice, Internal medicine, Type 1 diabetes and Immune system. His research related to Autoimmunity, T cell, Antigen, Gut flora and Autoimmune disease might be considered part of Immunology. His Autoimmunity study combines topics in areas such as Autoantibody and B cell.
His NOD mice research is under the purview of Nod. As part of the same scientific family, he usually focuses on Internal medicine, concentrating on Endocrinology and intersecting with Mitochondrion. In Type 1 diabetes, Li Wen works on issues like Disease, which are connected to Pathogenesis.
His primary areas of study are Acute pancreatitis, Pancreatitis, Cancer research, NOD mice and Pancreas. Li Wen combines subjects such as Tumor necrosis factor alpha, Calcineurin, Macrophage polarization, Pharmacology and ORAI1 with his study of Acute pancreatitis. His work on Acinar cell as part of general Pancreatitis research is frequently linked to Trypsinogen activation and Multiple species, bridging the gap between disciplines.
His Cancer research research incorporates elements of Genetically modified mouse, Gene knockdown, Regeneration and Pancreatic islets. The concepts of his NOD mice study are interwoven with issues in Cytotoxic T cell and Gut flora. His study focuses on the intersection of Nod and fields such as Innate immune system with connections in the field of Interleukin 10.
Cancer research, NOD mice, Pancreatitis, Acinar cell and Pancreas are his primary areas of study. The study incorporates disciplines such as Cytotoxic T cell, Gut flora, Immune tolerance and CD20 in addition to NOD mice. Immunology covers Li Wen research in Gut flora.
His work deals with themes such as Insulin and Proinsulin, which intersect with Immunology. His studies deal with areas such as Downregulation and upregulation and Acute pancreatitis as well as Acinar cell. As a part of the same scientific family, Li Wen mostly works in the field of Nod, focusing on Immune system and, on occasion, Proinflammatory cytokine and Microbiome.
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Innate immunity and intestinal microbiota in the development of Type 1 diabetes
Li Wen;Ruth E. Ley;Ruth E. Ley;Pavel Yu. Volchkov;Peter B. Stranges.
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.
F. Susan Wong;Jaana Karttunen;Caroline Dumont;Li Wen.
Nature Medicine (1999)
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.
F. S. Wong;I. Visintin;Li Wen;R. A. Flavell.
Journal of Experimental Medicine (1996)
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice
Chang-yun Hu;Daniel Rodriguez-Pinto;Wei Du;Anupama Ahuja.
Journal of Clinical Investigation (2007)
T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium
S J Roberts;A L Smith;A B West;L Wen.
Proceedings of the National Academy of Sciences of the United States of America (1996)
Factors Influencing the Gut Microbiota, Inflammation, and Type 2 Diabetes
Li Wen;Andrew Duffy.
Journal of Nutrition (2017)
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.
James A. Pearson;F. Susan Wong;Li Wen.
Journal of Autoimmunity (2016)
Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.
F. Susan Wong;Li Wen;Michelle Tang;Murugappan Ramanathan.
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity
Ningwen Tai;F. Susan Wong;Li Wen.
Reviews in Endocrine & Metabolic Disorders (2015)
Murine lupus in the absence of alpha beta T cells.
S. L. Peng;M. P. Madaio;D. P. M. Hughes;I. N. Crispe.
Journal of Immunology (1996)
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