D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 47 Citations 9,910 136 World Ranking 2995 National Ranking 1410

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Immune system
  • Internal medicine

Li Wen spends much of his time researching Immunology, NOD mice, Internal medicine, Type 1 diabetes and Endocrinology. His study involves Immune system, Autoantibody, Insulitis, Autoimmunity and Gut flora, a branch of Immunology. His study with NOD mice involves better knowledge in Nod.

His Internal medicine research is multidisciplinary, incorporating perspectives in Autophagy and Aldose reductase. Li Wen works mostly in the field of Type 1 diabetes, limiting it down to topics relating to CD8 and, in certain cases, MHC class II, Cytokine and Molecular biology. His Endocrinology study incorporates themes from Thapsigargin, Acute pancreatitis, Store-operated calcium entry and Pancreatitis.

His most cited work include:

  • Innate immunity and intestinal microbiota in the development of Type 1 diabetes (1479 citations)
  • Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. (404 citations)
  • Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice (348 citations)

What are the main themes of his work throughout his whole career to date?

Li Wen mainly investigates Immunology, NOD mice, Internal medicine, Type 1 diabetes and Immune system. His research related to Autoimmunity, T cell, Antigen, Gut flora and Autoimmune disease might be considered part of Immunology. His Autoimmunity study combines topics in areas such as Autoantibody and B cell.

His NOD mice research is under the purview of Nod. As part of the same scientific family, he usually focuses on Internal medicine, concentrating on Endocrinology and intersecting with Mitochondrion. In Type 1 diabetes, Li Wen works on issues like Disease, which are connected to Pathogenesis.

He most often published in these fields:

  • Immunology (57.44%)
  • NOD mice (28.51%)
  • Internal medicine (23.55%)

What were the highlights of his more recent work (between 2018-2021)?

  • Acute pancreatitis (19.42%)
  • Pancreatitis (16.53%)
  • Cancer research (12.40%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Acute pancreatitis, Pancreatitis, Cancer research, NOD mice and Pancreas. Li Wen combines subjects such as Tumor necrosis factor alpha, Calcineurin, Macrophage polarization, Pharmacology and ORAI1 with his study of Acute pancreatitis. His work on Acinar cell as part of general Pancreatitis research is frequently linked to Trypsinogen activation and Multiple species, bridging the gap between disciplines.

His Cancer research research incorporates elements of Genetically modified mouse, Gene knockdown, Regeneration and Pancreatic islets. The concepts of his NOD mice study are interwoven with issues in Cytotoxic T cell and Gut flora. His study focuses on the intersection of Nod and fields such as Innate immune system with connections in the field of Interleukin 10.

Between 2018 and 2021, his most popular works were:

  • The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis. (25 citations)
  • The Orai Ca2+ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis. (25 citations)
  • Dendritic cells license regulatory B cells to produce IL-10 and mediate suppression of antigen-specific CD8 T cells. (16 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Immune system
  • Internal medicine

Cancer research, NOD mice, Pancreatitis, Acinar cell and Pancreas are his primary areas of study. The study incorporates disciplines such as Cytotoxic T cell, Gut flora, Immune tolerance and CD20 in addition to NOD mice. Immunology covers Li Wen research in Gut flora.

His work deals with themes such as Insulin and Proinsulin, which intersect with Immunology. His studies deal with areas such as Downregulation and upregulation and Acute pancreatitis as well as Acinar cell. As a part of the same scientific family, Li Wen mostly works in the field of Nod, focusing on Immune system and, on occasion, Proinflammatory cytokine and Microbiome.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Innate immunity and intestinal microbiota in the development of Type 1 diabetes

Li Wen;Ruth E. Ley;Ruth E. Ley;Pavel Yu. Volchkov;Peter B. Stranges.
Nature (2008)

1802 Citations

Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.

F. Susan Wong;Jaana Karttunen;Caroline Dumont;Li Wen.
Nature Medicine (1999)

510 Citations

CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.

F. S. Wong;I. Visintin;Li Wen;R. A. Flavell.
Journal of Experimental Medicine (1996)

498 Citations

Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in mice

Chang-yun Hu;Daniel Rodriguez-Pinto;Wei Du;Anupama Ahuja.
Journal of Clinical Investigation (2007)

406 Citations

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium

S J Roberts;A L Smith;A B West;L Wen.
Proceedings of the National Academy of Sciences of the United States of America (1996)

339 Citations

Investigation of the role of B-cells in type 1 diabetes in the NOD mouse.

F. Susan Wong;Li Wen;Michelle Tang;Murugappan Ramanathan.
Diabetes (2004)

245 Citations

Immunoglobulin synthesis and generalized autoimmunity in mice congenitally deficient in αβ(+) T cells

Li Wen;Scott J. Roberts;Joanne L. Viney;F. Susan Wong.
Nature (1994)

227 Citations

Murine lupus in the absence of αβ T cells

Stanford L. Peng;Michael P. Madaio;Dennis P.M. Hughes;I. Nicholas Crispe.
Journal of Immunology (1996)

219 Citations

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes.

James A. Pearson;F. Susan Wong;Li Wen.
Journal of Autoimmunity (2016)

195 Citations

Induction and acceleration of insulitis/diabetes in mice with a viral mimic (polyinosinic-polycytidylic acid) and an insulin self-peptide.

Hiroaki Moriyama;Li Wen;Norio Abiru;Edwin Liu.
Proceedings of the National Academy of Sciences of the United States of America (2002)

182 Citations

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Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking d-index is inferred from publications deemed to belong to the considered discipline.

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