David V. Serreze

Overview

Best Publications

• Single domain antibodies: promising experimental and therapeutic tools in infection and immunity.

  Janusz Wesolowski;Vanina Alzogaray;Jan Reyelt;Mandy Unger

  726
  Citations

• B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null mice.

  D V Serreze;H D Chapman;D S Varnum;M S Hanson

  721
  Citations

• Interleukin 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice.

  M J Rapoport;A Jaramillo;D Zipris;A H Lazarus

  612
  Citations

• B Lymphocytes Are Critical Antigen-Presenting Cells for the Initiation of T Cell-Mediated Autoimmune Diabetes in Nonobese Diabetic Mice

  David V. Serreze;Sara A. Fleming;Harold D. Chapman;Scott D. Richard

  571
  Citations

• Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

  Rulang Jiang;Yu Lan;Harry D. Chapman;Carrie Shawber

  539
  Citations

• Identification of the β cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes

  Scott M. Lieberman;Anne M. Evans;Bingye Han;Toshiyuki Takaki

  489
  Citations

• Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

  Jun Yamanouchi;Dan Rainbow;Pau Serra;Sarah Howlett

  472
  Citations

• TRPV1+ sensory neurons control beta cell stress and islet inflammation in autoimmune diabetes.

  Rozita Razavi;Yin Chan;F. Nikoo Afifiyan;Xue Jun Liu

  431
  Citations

• Three recessive loci required for insulin-dependent diabetes in nonobese diabetic mice.

  Michal Prochazka;Edward H. Leiter;David V. Serreze;Douglas L. Coleman

  405
  Citations

• Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

  David V Serreze;Edward H Leiter;Gregory J Christianson;Dale Greiner

  400
  Citations

• Defects in the differentiation and function of antigen presenting cells in NOD/Lt mice.

  D V Serreze;H R Gaskins;E H Leiter

  313
  Citations

• Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

  Teresa P. DiLorenzo;Robert T. Graser;Toshiro Ono;Toshiro Ono;Gregory J. Christianson

  276
  Citations

• Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies.

  D V Serreze;E H Leiter

  261
  Citations

• Acceleration of type 1 diabetes by a coxsackievirus infection requires a preexisting critical mass of autoreactive T-cells in pancreatic islets.

  David V. Serreze;Eric W. Ottendorfer;Tamir M. Ellis;Charles J. Gauntt

  250
  Citations

• Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease.

  John P. Driver;David V. Serreze;Yi-Guang Chen

  236
  Citations

• Immunostimulation circumvents diabetes in NOD/Lt mice.

  David V. Serreze;Kazuyuki Hamaguchi;Edward H. Leiter

  235
  Citations

• Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C

  David V. Serreze;Jens W. Gaedeke;Edward H. Leiter

  231
  Citations

• The preferential ability of B lymphocytes to act as diabetogenic APC in NOD mice depends on expression of self-antigen-specific immunoglobulin receptors.

  Pablo A. Silveira;Ellis Johnson;Harold D. Chapman;Thi Bui

  219
  Citations

• Use of recombinant congenic and congenic strains of NOD mice to identify a new insulin-dependent diabetes resistance gene.

  D V Serreze;M Prochazka;P C Reifsnyder;M M Bridgett

  219
  Citations

• Identification of a CD8 T Cell That Can Independently Mediate Autoimmune Diabetes Development in the Complete Absence of CD4 T Cell Helper Functions

  Robert T. Graser;Teresa P. DiLorenzo;Fuming Wang;Gregory J. Christianson

  216
  Citations

• Th1 to Th2 Cytokine Shifts in Nonobese Diabetic Mice: Sometimes an Outcome, Rather Than the Cause, of Diabetes Resistance Elicited by Immunostimulation

  David V. Serreze;Harold D. Chapman;Cristina M. Post;Ellis A. Johnson

  212
  Citations