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Immunology

D-Index
80
Citations
25887
World Ranking
1616
National Ranking
139

Overview

Linda S. Wicker is affiliated with the University of Oxford in the United Kingdom and specializes in fields related to immunology, microbiology, and medicine. Their research output spans multiple disciplines including biochemistry, genetics, and molecular biology.

Their work covers main areas such as:

  • Immunology and Microbiology
  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Within these fields, their subfields of focus include:

  • Immunology
  • Genetics
  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Physiology

Key topics researched by Linda S. Wicker include:

  • Immune Cell Function and Interaction
  • Diabetes and associated disorders
  • Pancreatic function and diabetes
  • T-cell and B-cell Immunology
  • Diabetes Management and Research
  • Adenosine and Purinergic Signaling
  • Systemic Lupus Erythematosus Research

Notable recent publications include:

  • "Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes" (2021) published in Nature Genetics
  • "Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis" (2020) published in Genome Medicine
  • "Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes" (2020) published in bioRxiv (Cold Spring Harbor Laboratory)
  • "Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73" (2021) published in Communications Biology
  • "SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile" (2023) published in Genome Medicine

Frequent co-authors in their research collaborations include:

  • John A. Todd
  • Ricardo C. Ferreira
  • Mercede Lee
  • David B. Dunger
  • Dominik Trzupek

Their publications appear most often in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Wellcome Open Research
  • Genome Medicine
  • Nature Communications
  • Nature Genetics

Best Publications

  • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

    H Ueda;Howson Jmm.;L Esposito;J Heward

  • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

    John A. Todd;Neil M. Walker;Jason D. Cooper;Deborah J. Smyth

  • Genetic Control of Autoimmune Diabetes in the Nod Mouse

    Linda S Wicker;John A Todd;Laurence B Peterson

  • Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

    B J Miller;M C Appel;J J O'Neil;L S Wicker

  • Genetic analysis of autoimmune type 1 diabetes mellitus in mice.

    J A Todd;T J Aitman;R J Cornall;S Ghosh

  • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

    Christopher E Lowe;Jason D Cooper;Todd Brusko;Neil M Walker

  • Transfer of autoimmune diabetes mellitus with splenocytes from nonobese diabetic (NOD) mice

    Linda S Wicker;Beverly J Miller;Yoko Mullen

  • Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity

    Jun Yamanouchi;Dan Rainbow;Pau Serra;Sarah Howlett

  • Photochemical preparation of a pyridone containing tetracycle: A jak protein kinase inhibitor

    James E. Thompson;Rose M. Cubbon;Richard T. Cummings;Linda S. Wicker

  • Polygenic control of autoimmune diabetes in nonobese diabetic mice

    Ghosh S;Palmer Sm;Rodrigues Nr;Cordell Hj

  • Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetes.

    Linda S Wicker;Edward H Leiter;John A Todd;Robert J Renjilian

  • A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

    Ricardo C. Ferreira;Hui Guo;Richard M R Coulson;Deborah J. Smyth

  • Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

    Calliope A Dendrou;Vincent Plagnol;Erik Fung;Jennie H M Yang

  • Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.

    E Y M G Fung;D J Smyth;J M M Howson;J D Cooper

  • Genetic control of diabetes and insulitis in the nonobese diabetic (NOD) mouse.

    L S Wicker;B J Miller;L Z Coker;S E McNally

  • An Autoimmune Disease-Associated CTLA-4 Splice Variant Lacking the B7 Binding Domain Signals Negatively in T Cells

    Lalitha Vijayakrishnan;Jacqueline M Slavik;Zsolt Illés;Rebecca J Greenwald

  • IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

    Lisa M. Maier;Lisa M. Maier;Christopher E. Lowe;Jason Cooper;Kate Downes

  • Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models.

    John A Todd;Linda S Wicker

  • Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes.

    C C Robertson;Inshaw Jrj.;S Onengut-Gumuscu;Chen W-M.

  • CD226 Gly307Ser association with multiple autoimmune diseases

    J P Hafler;L M Maier;J D Cooper;V Plagnol

  • Liver Autoimmunity Triggered by Microbial Activation of Natural Killer T Cells

    Jochen Mattner;Jochen Mattner;Paul B. Savage;Patrick S Leung;Sabine S. Oertelt

Frequent Co-Authors

John A. Todd
John A. Todd University of Oxford
Laurence B. Peterson
Laurence B. Peterson Roche (Switzerland)
Deborah J. Smyth
Deborah J. Smyth University of Cambridge
Chris Wallace
Chris Wallace University of Cambridge
Paul A. Lyons
Paul A. Lyons University of Cambridge
David B. Dunger
David B. Dunger University of Cambridge
Jason D. Cooper
Jason D. Cooper AstraZeneca
Joanna M. M. Howson
Joanna M. M. Howson Novo Nordisk (United Kingdom)
Vijay K. Kuchroo
Vijay K. Kuchroo Harvard University
Linda A. Sherman
Linda A. Sherman Scripps Research Institute

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