World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
60
Citations
23599
World Ranking
11685
National Ranking
900

Overview

Deborah J. Smyth is affiliated with the University of Cambridge in the United Kingdom. Their research focus lies primarily in the fields of Immunology and Microbiology as well as Biochemistry, Genetics, and Molecular Biology. Smyth's expertise covers several subfields, including Immunology, Molecular Biology, Genetics, Oncology, and Cancer Research.

The scientist's recent publications address various aspects of immune cell function and genetic regulation, particularly related to CD4+ T cells and immune disease variants. Notable recent papers include:

  • "Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines," 2020, Nature Communications
  • "Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation," 2022, Nature Genetics
  • "Immune disease variants modulate gene expression in regulatory CD4+ T cells," 2022, Cell Genomics
  • "Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation," 2021, bioRxiv (Cold Spring Harbor Laboratory)
  • "Multiplex melanoma families are enriched for polygenic risk," 2020, Human Molecular Genetics

Smyth frequently collaborates with other researchers, among whom the most common co-authors are Eddie Cano-Gamez, Gosia Trynka, Lara Bossini-Castillo, Blagoje Soskic, and Nikolina Nakić. These collaborations contribute to the advancement of knowledge in immune cell regulation and genetic associations.

The primary publication outlets for Smyth's work include:

  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • Nature Genetics
  • Cell Genomics
  • bioRxiv (Cold Spring Harbor Laboratory)

The main research topics covered in Smyth's body of work are:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Single-cell and spatial transcriptomics
  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Cutaneous Melanoma Detection and Management
  • Cancer Genomics and Diagnostics

Overall, Smyth's research contributes to understanding the molecular and cellular mechanisms underlying immune responses, particularly through the use of advanced transcriptomic techniques and genetic analysis in the context of disease variants and cancer risk.

Best Publications

  • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

    H Ueda;Howson Jmm.;L Esposito;J Heward

  • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

    Jeffrey C Barrett;David G Clayton;Patrick Concannon;Beena Akolkar

  • Common genetic determinants of vitamin D insufficiency: a genome-wide association study

    Thomas J. Wang;Feng Zhang;J. Brent Richards;Bryan Kestenbaum

  • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.

    John A. Todd;Neil M. Walker;Jason D. Cooper;Deborah J. Smyth

  • Shared and distinct genetic variants in type 1 diabetes and celiac disease.

    Deborah J. Smyth;Vincent Plagnol;Neil M. Walker;Jason D. Cooper

  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls

    Nick Craddock;Matthew E. Hurles;Niall Cardin;Richard D. Pearson

  • A genome-wide association study of nonsynonymous SNPs identifies a type 1 diabetes locus in the interferon-induced helicase (IFIH1) region.

    Deborah J Smyth;Jason D Cooper;Rebecca Bailey;Sarah Field

  • Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A

    Sergey Nejentsev;Joanna M. M. Howson;Neil M. Walker;Jeffrey Szeszko

  • Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage

    Ivan Angulo;Oscar Vadas;Fabien Garçon;Edward Banham-Hall

  • Replication of an Association Between the Lymphoid Tyrosine Phosphatase Locus (LYP/PTPN22) With Type 1 Diabetes, and Evidence for Its Role as a General Autoimmunity Locus

    Deborah Smyth;Jason D. Cooper;Joanne E. Collins;Joanne M. Heward

  • Population structure, differential bias and genomic control in a large-scale, case-control association study.

    David G Clayton;Neil M Walker;Deborah J Smyth;Rebecca Pask

  • Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

    Jason D Cooper;Deborah J Smyth;Adam M Smiles;Vincent Plagnol

  • Widespread seasonal gene expression reveals annual differences in human immunity and physiology

    Xaquin Castro Dopico;Marina Evangelou;Ricardo C. Ferreira;Hui Guo

  • Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

    Christopher E Lowe;Jason D Cooper;Todd Brusko;Neil M Walker

  • The imprinted DLK1 - MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

    Chris Wallace;Deborah J Smyth;Meeta Maisuria-Armer;Neil M Walker

  • Inherited Variation in Vitamin D Genes Is Associated With Predisposition to Autoimmune Disease Type 1 Diabetes

    Jason D. Cooper;Deborah J. Smyth;Neil M. Walker;Helen Stevens

  • A Type I Interferon Transcriptional Signature Precedes Autoimmunity in Children Genetically at Risk for Type 1 Diabetes

    Ricardo C. Ferreira;Hui Guo;Richard M R Coulson;Deborah J. Smyth

  • A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk

    Matthias Heinig;Enrico Petretto;Chris Wallace;Leonardo Bottolo

  • Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus.

    E Y M G Fung;D J Smyth;J M M Howson;J D Cooper

  • Functional IL6R 358Ala Allele Impairs Classical IL-6 Receptor Signaling and Influences Risk of Diverse Inflammatory Diseases

    Ricardo C. Ferreira;Daniel F. Freitag;Antony J. Cutler;Joanna M. M. Howson

Frequent Co-Authors

John A. Todd
John A. Todd University of Oxford
Jason D. Cooper
Jason D. Cooper AstraZeneca
Linda S. Wicker
Linda S. Wicker University of Oxford
Joanna M. M. Howson
Joanna M. M. Howson Novo Nordisk (United Kingdom)
Chris Wallace
Chris Wallace University of Cambridge
David B. Dunger
David B. Dunger University of Cambridge
David G. Clayton
David G. Clayton University of Cambridge
Vincent Plagnol
Vincent Plagnol University College London
Stephen S. Rich
Stephen S. Rich University of Virginia
Willem H. Ouwehand
Willem H. Ouwehand University of Cambridge

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