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Constantin Polychronakos

Constantin Polychronakos

D-Index & Metrics

Genetics

D-Index
70
Citations
22481
World Ranking
2250
National Ranking
76

Research.com Recognitions

  • 2014 - Fellow of the Royal Society of Canada Academy of Science

Overview

Constantin Polychronakos is affiliated with the McGill University Health Centre in Canada. Their research focuses primarily on medicine, with substantial contributions to biochemistry, genetics, and molecular biology. Within these broader fields, their work addresses genetics, surgery, endocrinology, diabetes and metabolism, molecular biology, and immunology.

The scientist's work centers on topics related to diabetes and associated disorders, pancreatic function and diabetes, metabolism and cancer, diabetes management and research, genetic associations and epidemiology, renal transplantation outcomes and treatments, and diabetes treatment and management.

Polychronakos has published several significant papers, including:

  • "Rare Genetic Variants of Large Effect Influence Risk of Type 1 Diabetes," 2020, Diabetes
  • "Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study," 2021, PLoS Medicine
  • "Clinically Relevant Circulating Protein Biomarkers for Type 1 Diabetes: Evidence From a Two-Sample Mendelian Randomization Study," 2021, Diabetes Care
  • "Correction: Vitamin D levels and risk of type 1 diabetes: A Mendelian randomization study," 2021, PLoS Medicine
  • "Causal variants in Maturity Onset Diabetes of the Young (MODY) - A systematic review," 2021, BMC Endocrine Disorders

Their frequent coauthors include Despoina Manousaki, Luc Marchand, Hákon Hákonarson, Jonathan P. Bradfield, and Vincenzo Forgetta.

Common publication venues for Polychronakos's work comprise Frontiers in Immunology, UNC Libraries, Diabetes, PLoS Medicine, and Communications Biology.

Polychronakos was named a Fellow of the Royal Society of Canada in 2014 by the Academy of Science.

Best Publications

  • A genome-wide association study identifies novel risk loci for type 2 diabetes

    Robert Sladek;Ghislain Rocheleau;Johan Rung;Christian Dina

  • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus

    Petros Vafiadis;Simon T. Bennett;John A. Todd;Joseph Nadeau

  • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

    David Meyre;Jérôme Delplanque;Jean-Claude Chèvre;Cécile Lecoeur

  • A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene

    Hakon Hakonarson;Struan F A Grant;Jonathan P. Bradfield;Luc Marchand

  • Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease

    David Neil Cooper;Michael Krawczak;Constantin Polychronakos;Chris Tyler-Smith

  • Guidelines for Growth Hormone and Insulin-Like Growth Factor-I Treatment in Children and Adolescents: Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-I Deficiency.

    Adda Grimberg;Sara A. DiVall;Constantin Polychronakos;David B. Allen

  • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

    Johan Rung;Stéphane Cauchi;Anders Albrechtsen;Lishuang Shen;Lishuang Shen

  • Parental genomic imprinting of the human IGF2 gene.

    Nick Giannoukakis;Cheri Deal;Jean Paquette;Cynthia G. Goodyer

  • Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care.

    S L Sawyer;T Hartley;D A Dyment;C L Beaulieu

  • Rfx6 directs islet formation and insulin production in mice and humans

    Stuart B. Smith;Hui Qi Qu;Nadine Taleb;Nina Y. Kishimoto

  • A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci.

    Jonathan P. Bradfield;Hui Qi Qu;Kai Wang;Haitao Zhang

  • Divergence between genetic determinants of IGF2 transcription levels in leukocytes and of IDDM2-encoded susceptibility to type 1 diabetes.

    Petros Vafiadis;Simon T. Bennett;John A. Todd;Rosemarie Grabs

  • A Common Autoimmunity Predisposing Signal Peptide Variant of the Cytotoxic T-lymphocyte Antigen 4 Results in Inefficient Glycosylation of the Susceptibility Allele

    Suzana Anjos;Audrey Nguyen;Houria Ounissi-Benkalha;Marie-Catherine Tessier

  • What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations

    Orestis A. Panagiotou;John P.A. Ioannidis;John P.A. Ioannidis;John P.A. Ioannidis;Joel N. Hirschhorn;Goncalo R. Abecasis

  • Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients

    Michael Pollak;Joseph Costantino;Constantin Polychronakos;Sue-Ann Blauer

  • Insulin Expression Levels in the Thymus Modulate Insulin-Specific Autoreactive T-Cell Tolerance: The Mechanism by Which the IDDM2 Locus May Predispose to Diabetes

    Aziz Alami Chentoufi;Constantin Polychronakos

  • Understanding type 1 diabetes through genetics: advances and prospects

    Constantin Polychronakos;Quan Li

  • A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels

    Nabila Bouatia-Naji;Ghislain Rocheleau;Leentje Van Lommel;Katleen Lemaire

  • Impedance‐based detection of DNA sequences using a silicon transducer with PNA as the probe layer

    A. Macanovic;C. Marquette;C. Polychronakos;M. F. Lawrence

  • From disease association to risk assessment: an optimistic view from genome-wide association studies on type 1 diabetes.

    Zhi Wei;Kai Wang;Hui Qi Qu;Haitao Zhang

Frequent Co-Authors

Hakon Hakonarson
Hakon Hakonarson Children's Hospital of Philadelphia
Struan F.A. Grant
Struan F.A. Grant University of Pennsylvania
Jonathan P. Bradfield
Jonathan P. Bradfield Children's Hospital of Philadelphia
Philippe Froguel
Philippe Froguel Imperial College London
Barry I. Posner
Barry I. Posner McGill University
Robert Sladek
Robert Sladek McGill University
Thomas J. Hudson
Thomas J. Hudson Ontario Institute for Cancer Research
Dimitri S. Monos
Dimitri S. Monos Children's Hospital of Philadelphia
Joseph T. Glessner
Joseph T. Glessner Children's Hospital of Philadelphia
Alexandre Montpetit
Alexandre Montpetit McGill University

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Related Online Degrees & Career Pathways

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