World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Genetics
UK
2026

D-Index & Metrics

Best Scientists

D-Index
196
Citations
171197
World Ranking
336
National Ranking
38

Genetics

D-Index
194
Citations
161375
World Ranking
28
National Ranking
4

Medicine

D-Index
195
Citations
170659
World Ranking
212
National Ranking
27

Research.com Recognitions

  • 2026 - Research.com Genetics in United Kingdom Leader Award
  • 2026 - Research.com Medicine in United Kingdom Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Genetics in United Kingdom Leader Award
  • 2025 - Research.com Medicine in United Kingdom Leader Award
  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2023 - Research.com Medicine in United Kingdom Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award

Overview

Philippe Froguel is affiliated with Imperial College London in the United Kingdom. Their research intersects key areas within biochemistry, genetics, molecular biology, and medicine. The scientist's main fields of study include biochemistry, genetics and molecular biology with 172 publications, and medicine with 162 publications. Their work further specializes in subfields such as molecular biology, genetics, surgery, endocrinology, diabetes and metabolism, and physiology.

The research topics covered by Philippe Froguel emphasize pancreatic function and diabetes, genetic associations and epidemiology, epigenetics and DNA methylation, genetics and neurodevelopmental disorders, diabetes and associated disorders, liver disease diagnosis and treatment, and diet and metabolism studies.

The scientist has published extensively, with recent papers including:

  • A reference map of potential determinants for the human serum metabolome, 2020, Nature
  • Bidirectional Mendelian Randomization and Multiphenotype GWAS Show Causality and Shared Pathophysiology Between Depression and Type 2 Diabetes, 2023, Diabetes Care
  • Monogenic diabetes, 2023, Nature Reviews Disease Primers
  • Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes, 2020, Cell Reports
  • Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes, 2022, Human Molecular Genetics

Philippe Froguel frequently collaborates with several researchers, including:

  • Amélie Bonnefond
  • Mickaël Canouil
  • Mehdi Derhourhi
  • François Pattou
  • Amna Khamis

The scientist's work is published in a variety of venues, with some journals and platforms appearing more frequently, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Diabetes
  • UNC Libraries
  • Nature Communications
  • Diabetes Care

Best Publications

  • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity

    T. Yamauchi;J. Kamon;H. Waki;Y. Terauchi

  • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

    T Yamauchi;J Kamon;Y Minokoshi;Y Ito

  • Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

    Toshimasa Yamauchi;Junji Kamon;Yusuke Ito;Atsushi Tsuchida

  • A genome-wide association study identifies novel risk loci for type 2 diabetes

    Robert Sladek;Ghislain Rocheleau;Johan Rung;Christian Dina

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

    Elizabeth K. Speliotes;Elizabeth K. Speliotes;Cristen J. Willer;Sonja I. Berndt;Keri L. Monda

  • A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction

    Karine Clément;Christian Vaisse;Najiba Lahlou;Sylvie Cabrol

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Josée Dupuis;Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena;Richa Saxena

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)

    J Dupuis;C Langenberg;I Prokopenko;R Saxena

  • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    Benjamin F. Voight;Benjamin F. Voight;Laura J. Scott;Valgerdur Steinthorsdottir;Andrew P. Morris

  • Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

    Andrew P Morris;Benjamin F Voight;Benjamin F Voight;Tanya M Teslovich;Teresa Ferreira

  • Disruption of adiponectin causes insulin resistance and neointimal formation.

    Naoto Kubota;Yasuo Terauchi;Toshimasa Yamauchi;Tetsuya Kubota

  • Variation in FTO contributes to childhood obesity and severe adult obesity

    Christian Dina;David Meyre;Sophie Gallina;Emmanuelle Durand

  • A genome-wide association search for type 2 diabetes genes in African Americans.

    N D Palmer;C W McDonough;P J Hicks;B H Roh

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions.

    Toshimasa Yamauchi;Yasunori Nio;Toshiyuki Maki;Masaki Kobayashi

  • Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

    Anubha Mahajan;Daniel Taliun;Matthias Thurner;Neil R. Robertson

  • A frameshift mutation in human MC4R is associated with a dominant form of obesity

    Christian Vaisse;Karine Clement;Bernard Guy-Grand;Philippe Froguel

  • Impaired Multimerization of Human Adiponectin Mutants Associated with Diabetes MOLECULAR STRUCTURE AND MULTIMER FORMATION OF ADIPONECTIN

    Hironori Waki;Toshimasa Yamauchi;Junji Kamon;Yusuke Ito

  • Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

    Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena

Frequent Co-Authors

David Meyre
David Meyre University of Lorraine
Loic Yengo
Loic Yengo University of Queensland
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Oluf Pedersen
Oluf Pedersen University of Copenhagen
Christian Dina
Christian Dina University of Nantes
John C. Chambers
John C. Chambers Guy's and St Thomas' NHS Foundation Trust
Inga Prokopenko
Inga Prokopenko University of Surrey
Torben Hansen
Torben Hansen University of Copenhagen

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