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Medicine

D-Index
144
Citations
102790
World Ranking
1415
National Ranking
147

Overview

John C. Chambers is affiliated with Guy's and St Thomas' NHS Foundation Trust in the United Kingdom. Their research spans primarily across the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, where they have produced a substantial number of publications.

The scientist's work involves several main topics, including:

  • Genetic Associations and Epidemiology
  • Epigenetics and DNA Methylation
  • Genomics and Rare Diseases
  • Liver Disease Diagnosis and Treatment
  • Diabetes, Cardiovascular Risks, and Lipoproteins
  • Global Public Health Policies and Epidemiology
  • Diabetes Management and Education

Their frequent co-authors demonstrate collaboration within the scientific community and include:

  • Marie Loh
  • Jaspal S. Kooner
  • Anuradhani Kasturiratne
  • Michael Boehnke
  • Khadija Irfan Khawaja

Publication venues where they have contributed multiple works include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • UNC Libraries
  • Nature
  • Nature Genetics

Some of the notable recent papers that include their research contributions are:

  • The mutational constraint spectrum quantified from variation in 141,456 humans, 2020, Nature
  • A structural variation reference for medical and population genetics, 2020, Nature
  • A genomic mutational constraint map using variation in 76,156 human genomes, 2023, Nature
  • Identification of type 2 diabetes loci in 433,540 East Asian individuals, 2020, Nature
  • Transcript expression-aware annotation improves rare variant interpretation, 2020, Nature

The scientist's subfields of study encompass Genetics, Molecular Biology, Endocrinology, Diabetes and Metabolism, Physiology, and Cardiology and Cardiovascular Medicine. This range indicates a multidisciplinary approach to studying the genetic and molecular bases of disease and health.

Best Publications

  • Echocardiographic assessment of valve stenosis: EAE/ASE recommendations for clinical practice

    Helmut Baumgartner;Judy Hung;Javier Bermejo;John B. Chambers

  • Biological, clinical and population relevance of 95 loci for blood lipids

    Tanya M. Teslovich;Kiran Musunuru;Albert V. Smith;Andrew C. Edmondson

  • Discovery and refinement of loci associated with lipid levels

    Cristen J. Willer;Ellen M. Schmidt;Sebanti Sengupta;Gina M. Peloso;Gina M. Peloso;Gina M. Peloso

  • Homocysteine and risk of ischemic heart disease and stroke: A meta-analysis

    R. Clarke;R. Collins;S. Lewington;A. Donald

  • A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease

    M Nikpay;A Goel;Won H-H.;L M Hall

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Georg B. Ehret;Georg B. Ehret;Georg B. Ehret;Patricia B. Munroe;Kenneth M. Rice;Murielle Bochud

  • Defining the role of common variation in the genomic and biological architecture of adult human height

    Andrew R. Wood;Tonu Esko;Jian Yang;Sailaja Vedantam

  • Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis.

    Anne B. Rossebø;Terje R. Pedersen;Kurt Boman;Philippe Brudi

  • Large-scale association analysis identifies new risk loci for coronary artery disease

    Panos Deloukas;Stavroula Kanoni;Christina Willenborg;Martin Farrall

  • Recommendations on the Echocardiographic Assessment of Aortic Valve Stenosis: A Focused Update from the European Association of Cardiovascular Imaging and the American Society of Echocardiography

    Helmut Baumgartner;Judy Hung;Javier Bermejo;John B. Chambers

  • Genetic studies of body mass index yield new insights for obesity biology

    Adam E. Locke;Bratati Kahali;Sonja I. Berndt;Anne E. Justice

  • Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps.

    Anubha Mahajan;Daniel Taliun;Matthias Thurner;Neil R. Robertson

  • Common variants at 30 loci contribute to polygenic dyslipidemia.

    Sekar Kathiresan;Sekar Kathiresan;Sekar Kathiresan;Cristen J. Willer;Gina M. Peloso;Serkalem Demissie

  • Recommendations for Evaluation of Prosthetic Valves With Echocardiography and Doppler Ultrasound. A Report From the American Society of Echocardiography's Guidelines and Standards Committee and the Task Force on Prosthetic Valves, Developed in Conjunction With the American College of Cardiology Cardiovascular Imaging Committee, Cardiac Imaging Committee of the American Heart Association

    William A. Zoghbi;John B. Chambers;Jean G. Dumesnil;Elyse Foster

  • Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits.

    Evangelos Evangelou;Evangelos Evangelou;Helen R. Warren;Helen R. Warren;David Mosen-Ansorena;Borbala Mifsud

  • Genome-wide association study identifies eight loci associated with blood pressure

    Christopher Newton-Cheh;Christopher Newton-Cheh;Toby Johnson;Toby Johnson;Vesela Gateva;Martin D. Tobin

  • The genetic architecture of type 2 diabetes

    Christian Fuchsberger;Christian Fuchsberger;Jason A. Flannick;Jason A. Flannick;Tanya M. Teslovich;Anubha Mahajan

  • Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries

    Mary F. Feitosa;Aldi T. Kraja;Daniel I. Chasman;Yun J. Sung

  • Prasugrel versus clopidogrel for acute coronary syndromes without revascularization

    Matthew T. Roe;Paul W. Armstrong;Keith A.A. Fox;Harvey D. White

  • A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease

    Majid Nikpay;Anuj Goel;Hong-Hee Won;Leanne M. Hall

Frequent Co-Authors

Jaspal S. Kooner
Jaspal S. Kooner Imperial College London
Weihua Zhang
Weihua Zhang Imperial College London
Nilesh J. Samani
Nilesh J. Samani University of Leicester
Ruth J. F. Loos
Ruth J. F. Loos University of Copenhagen
Tonu Esko
Tonu Esko University of Tartu
Andrew P. Morris
Andrew P. Morris University of Liverpool
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Markus Perola
Markus Perola Finnish Institute for Health and Welfare
Erik Ingelsson
Erik Ingelsson Stanford University

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