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Robert Sladek

Robert Sladek

D-Index & Metrics

Genetics

D-Index
69
Citations
32242
World Ranking
2313
National Ranking
79

Overview

Robert Sladek is affiliated with McGill University in Canada and has a research focus spanning biochemistry, genetics, molecular biology, and medicine. Their work integrates molecular biology and genetics with medical applications, particularly within subfields such as molecular biology, genetics, surgery, physiology, and endocrinology, diabetes, and metabolism. The main topics covered in their research include genetic associations and epidemiology, pancreatic function and diabetes, epigenetics and DNA methylation, adipose tissue and metabolism, bioinformatics and genomic networks, genetic syndromes and imprinting, and RNA modifications and cancer.

Sladek's recent papers illustrate a concentration on metabolic traits, genetic factors in diabetes, and molecular phenotyping techniques. Some of the recent papers include:

  • Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes, 2021, Nature Communications
  • Molecular phenotyping of single pancreatic islet leader beta cells by "Flash-Seq", 2023, Life Sciences
  • Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population, 2020, Human Genetics
  • A Long Non-coding RNA, LOC157273, Is an Effector Transcript at the Chromosome 8p23.1-PPP1R3B Metabolic Traits and Type 2 Diabetes Risk Locus, 2020, Frontiers in Genetics
  • The Genetic Discrimination Observatory: confronting novel issues in genetic discrimination, 2021, Trends in Genetics

They have published frequently with several collaborators, the most frequent coauthors being Josée Dupuis, James B. Meigs, Jerome I. Rotter, Alexander P. Reiner, and Mark O. Goodarzi.

Sladek's work is commonly published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Molecular Metabolism, Cellular and Molecular Neurobiology, and NanoEthics.

Best Publications

  • A genome-wide association study identifies novel risk loci for type 2 diabetes

    Robert Sladek;Ghislain Rocheleau;Johan Rung;Christian Dina

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

    Josée Dupuis;Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena;Richa Saxena

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (vol 42, pg 105, 2010)

    J Dupuis;C Langenberg;I Prokopenko;R Saxena

  • Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

    Benjamin F. Voight;Benjamin F. Voight;Laura J. Scott;Valgerdur Steinthorsdottir;Andrew P. Morris

  • The genetic architecture of type 2 diabetes

    Christian Fuchsberger;Christian Fuchsberger;Jason A. Flannick;Jason A. Flannick;Tanya M. Teslovich;Anubha Mahajan

  • Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24

    Brent W. Zanke;Celia M.T. Greenwood;Celia M.T. Greenwood;Jagadish Rangrej;Rafal Kustra;Rafal Kustra

  • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

    David Meyre;Jérôme Delplanque;Jean-Claude Chèvre;Cécile Lecoeur

  • Characterizing the profile of obese patients who are metabolically healthy

    V. Primeau;L. Coderre;A. D. Karelis;A. D. Karelis;M. Brochu

  • Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

    Richa Saxena;Richa Saxena;Claudia Langenberg;Toshiko Tanaka;Toshiko Tanaka

  • Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics

    Vamsi K. Mootha;Pierre Lepage;Kathleen Miller;Jakob Bunkenborg

  • A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk

    Nabila Bouatia-Naji;Amélie Bonnefond;Amélie Bonnefond;Christine Cavalcanti-Proença;Christine Cavalcanti-Proença;Thomas Sparsø

  • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2

    R. G. Walters;S. Jacquemont;A. Valsesia;A. Valsesia;A. Valsesia;A. J. de Smith

  • Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals

    Z Dastani;Hivert M-F.;Hivert M-F.;N Timpson;Perry Jrb.;Perry Jrb.

  • Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

    Johan Rung;Stéphane Cauchi;Anders Albrechtsen;Lishuang Shen;Lishuang Shen

  • Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta

    Jiangming Luo;Robert Sladek;Jo-Ann Bader;Annie Matthyssen

  • Control Genes and Variability: Absence of Ubiquitous Reference Transcripts in Diverse Mammalian Expression Studies

    Peter D. Lee;Robert Sladek;Celia M.T. Greenwood;Thomas J. Hudson

  • Reduced Fat Mass in Mice Lacking Orphan Nuclear Receptor Estrogen-Related Receptor α

    Jiangming Luo;Robert Sladek;Julie Carrier;Jo-Ann Bader

  • The orphan nuclear receptor estrogen-related receptor alpha is a transcriptional regulator of the human medium-chain acyl coenzyme A dehydrogenase gene

    Robert Sladek;Jo-Ann Bader;Vincent Giguere

  • Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk (Nature Genetics (2010) 42 (105-116))

    Josée Dupuis;Claudia Langenberg;Inga Prokopenko;Richa Saxena

  • The genetic architecture of type 2 diabetes

    Christian Fuchsberger;Jason Flannick;Tanya M. Teslovich;Anubha Mahajan

Frequent Co-Authors

Philippe Froguel
Philippe Froguel Imperial College London
James B. Meigs
James B. Meigs Harvard University
Jose C. Florez
Jose C. Florez Harvard University
Josée Dupuis
Josée Dupuis McGill University
Torben Hansen
Torben Hansen University of Copenhagen
Leif Groop
Leif Groop Lund University
Oluf Pedersen
Oluf Pedersen University of Copenhagen
John C. Chambers
John C. Chambers Guy's and St Thomas' NHS Foundation Trust
Andrew P. Morris
Andrew P. Morris University of Liverpool

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