World's Best Scientists 2026 revealed!
Catherine C. Y. Chang

Catherine C. Y. Chang

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
9931
World Ranking
15155
National Ranking
6341

Overview

Catherine C. Y. Chang is affiliated with Dartmouth College in the United States and has a research focus spanning medicine, biochemistry, genetics, and molecular biology. Their work prominently intersects with surgery, molecular biology, neurology, physiology, and psychiatry and mental health as subfields of study.

The scientist's investigations largely address topics related to cholesterol and lipid metabolism, peroxisome proliferator-activated receptors, and lipoproteins in cardiovascular health. Other primary research areas include drug transport and resistance mechanisms, lipid membrane structure and behavior, RNA and protein synthesis mechanisms, and receptor mechanisms and signaling.

Chang has contributed to multiple research papers published in a variety of scientific journals. Some representative recent publications include:

  • "Cholesterol, Atherosclerosis, and APOE in Vascular Contributions to Cognitive Impairment and Dementia (VCID): Potential Mechanisms and Therapy," 2021, Frontiers in Aging Neuroscience
  • "Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor," 2020, Nature Communications
  • "Acute ACAT1/SOAT1 Blockade Increases MAM Cholesterol and Strengthens ER-Mitochondria Connectivity," 2023, International Journal of Molecular Sciences
  • "Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells," 2022, Proceedings of the National Academy of Sciences
  • "Blocking cholesterol storage to treat Alzheimer's disease," 2021, Exploration of Neuroprotective Therapy

Their frequent co-authors include Ta-Yuan Chang, Thao N. Huynh, Adrianna L. De La Torre, Matthew C. Havrda, and Dylan B. Ness.

Catherine C. Y. Chang's work has been published most often in the International Journal of Molecular Sciences and bioRxiv (Cold Spring Harbor Laboratory), with multiple contributions to each. Other frequently used venues include Frontiers in Aging Neuroscience, Nature Communications, and Proceedings of the National Academy of Sciences.

Best Publications

  • Cholesterol Sensing, Trafficking, and Esterification

    Ta-Yuan Chang;Catherine C Y Chang;Nobutaka Ohgami;Yoshio Yamauchi

  • ACYL-COENZYME A:CHOLESTEROL ACYLTRANSFERASE

    T. Y. Chang;Catherine C. Y. Chang;Dong Cheng

  • Acyl-coenzyme A:cholesterol acyltransferases.

    Ta-Yuan Chang;Bo-Liang Li;Catherine C. Y. Chang;Yasuomi Urano

  • Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells.

    Catherine C Y Chang;Ho Young Huh;Kenneth M. Cadigan;Ta Yuan Chang

  • Roles of acyl-coenzyme A:cholesterol acyltransferase-1 and -2.

    Ta-Yuan Chang;Catherine C.Y. Chang;Song Lin;Chunjiang Yu

  • Immunological Quantitation and Localization of ACAT-1 and ACAT-2 in Human Liver and Small Intestine

    Catherine C.Y. Chang;Naomi Sakashita;Kim Ornvold;Oneil Lee

  • Binding between the Niemann–Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain

    Nobutaka Ohgami;Dennis C. Ko;Matthew Thomas;Matthew P. Scott

  • ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

    Elena Y. Bryleva;Maximillian A. Rogers;Catherine C.Y. Chang;Floyd Buen

  • Activation of Acyl-Coenzyme A:Cholesterol Acyltransferase by Cholesterol or by Oxysterol in a Cell-free System

    Dong Cheng;Catherine C.Y. Chang;Xian-ming Qu;Ta-Yuan Chang

  • Niemann-Pick Type C Disease and Intracellular Cholesterol Trafficking

    Ta-Yuan Chang;Patrick C. Reid;Shigeki Sugii;Nobutaka Ohgami

  • Expression of ACAT-1 Protein in Human Atherosclerotic Lesions and Cultured Human Monocytes-Macrophages

    Akira Miyazaki;Naomi Sakashita;Oneil Lee;Kiyoshi Takahashi

  • Tissue-specific Expression and Cholesterol Regulation of Acylcoenzyme A:Cholesterol Acyltransferase (ACAT) in Mice: MOLECULAR CLONING OF MOUSE ACAT cDNA, CHROMOSOMAL LOCALIZATION, AND REGULATION OF ACAT IN VIVO AND IN VITRO

    Patricia J. Uelmen;Kazuhiro Oka;Merry Sullivan;Catherine C.Y. Chang

  • Molecular Cloning and Characterization of Two Isoforms of Saccharomyces cerevisiae Acyl-CoA:Sterol Acyltransferase

    Chunjiang Yu;Norman J. Kennedy;Catherine C.Y. Chang;Jonathan A. Rothblatt

  • Recombinant acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) purified to essential homogeneity utilizes cholesterol in mixed micelles or in vesicles in a highly cooperative manner.

    Catherine C.Y. Chang;Chi-Yu Gregory Lee;Ellen T. Chang;Jonathan C. Cruz

  • Human acyl-CoA:cholesterol acyltransferase-1 (ACAT-1) gene organization and evidence that the 4.3-kilobase ACAT-1 mRNA is produced from two different chromosomes.

    Bo-Liang Li;Xia-Lu Li;Zhi-Jun Duan;Oneil Lee

  • A novel mouse model of Niemann–Pick type C disease carrying a D1005G-Npc1 mutation comparable to commonly observed human mutations

    Robert A. Maue;Robert W. Burgess;Bing Wang;Christine M. Wooley

  • Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators.

    Maximillian A. Rogers;Jay Liu;Bao-Liang Song;Bo-Liang Li

  • Localization of Human Acyl-Coenzyme A:Cholesterol Acyltransferase-1 (ACAT-1) in Macrophages and in Various Tissues

    Naomi Sakashita;Akira Miyazaki;Motohiro Takeya;Seikoh Horiuchi

  • Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies

    Jay Liu;Catherine C. Y. Chang;Emily J. Westover;Douglas F. Covey

  • Immunodepletion experiments suggest that acyl-coenzyme A:cholesterol acyltransferase-1 (ACAT-1) protein plays a major catalytic role in adult human liver, adrenal gland, macrophages, and kidney, but not in intestines.

    Oneil Lee;Catherine C.Y. Chang;William Lee;Ta-Yuan Chang

Frequent Co-Authors

Ta-Yuan Chang
Ta-Yuan Chang Dartmouth College
Bao-Liang Song
Bao-Liang Song Wuhan University
Akira Miyazaki
Akira Miyazaki Showa University
Seikoh Horiuchi
Seikoh Horiuchi Kumamoto University
Li Yang
Li Yang Chinese Academy of Sciences
Motohiro Takeya
Motohiro Takeya Kumamoto Health Science University
William F. Hickey
William F. Hickey Dartmouth College
Kiyoshi Takahashi
Kiyoshi Takahashi Kumamoto University
Shinji Yokoyama
Shinji Yokoyama Chubu University
Salvatore Oddo
Salvatore Oddo Arizona State University

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