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Biology and Biochemistry

D-Index
80
Citations
42579
World Ranking
3981
National Ranking
29

Overview

Elina Ikonen is affiliated with the University of Helsinki in Finland and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with a focus on molecular biology, cell biology, surgery, biochemistry, and epidemiology. Their research primarily revolves around lipid metabolism and biosynthesis, cholesterol and lipid metabolism, endoplasmic reticulum stress and disease, lipid membrane structure and behavior, cellular transport and secretion, photosynthetic processes and mechanisms, and mitochondrial function and pathology.

Ikonen's publication record includes articles in various scientific venues, with frequent contributions to bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, The EMBO Journal, Contact, and the American Journal Of Pathology. These venues have hosted multiple publications that explore cellular and molecular processes related to lipid biology and membrane dynamics.

Notable recent papers authored or co-authored by Ikonen include:

  • "Lipid Droplet Nucleation" (2020) in Trends in Cell Biology
  • "Membrane Curvature Catalyzes Lipid Droplet Assembly" (2020) in Current Biology
  • "Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis" (2021) in Proceedings of the National Academy of Sciences
  • "Cholesterol transport between cellular membranes: A balancing act between interconnected lipid fluxes" (2021) in Developmental Cell
  • "Seipin traps triacylglycerols to facilitate their nanoscale clustering in the endoplasmic reticulum membrane" (2021) in PLoS Biology

Frequent collaborators in Ikonen's research endeavors include Shiqian Li, Veijo T. Salo, Vesa M. Olkkonen, Ilpo Vattulainen, and Eija Jokitalo, with repeated joint publications reflecting ongoing scientific partnerships.

Ikonen's research addresses complex biological mechanisms such as lipid droplet formation, cholesterol transport within cells, and the cellular response to lipid-related stress, contributing to a broad understanding of cellular metabolism and its links to disease processes. This work intersects with studies on endoplasmic reticulum function, membrane behavior, and mitochondrial pathology, showing a multidisciplinary approach to molecular and cellular biology.

Best Publications

  • Functional rafts in cell membranes

    Kai Simons;Elina Ikonen

  • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

    Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez

  • Cellular cholesterol trafficking and compartmentalization

    Elina Ikonen

  • How Cells Handle Cholesterol

    Kai Simons;Elina Ikonen

  • Roles of lipid rafts in membrane transport.

    Elina Ikonen

  • A Caveolin Dominant Negative Mutant Associates with Lipid Bodies and Induces Intracellular Cholesterol Imbalance

    Albert Pol;Robert Luetterforst;Margaret Lindsay;Sanna Heino

  • LOW PREVALENCE OF HUNTINGTONS-DISEASE IN FINLAND

    J Palo;H Somer;E Ikonen;L Karila

  • The impact of low-frequency and rare variants on lipid levels.

    Ida Surakka;Ida Surakka;Momoko Horikoshi;Reedik Mägi;Antti-Pekka Sarin;Antti-Pekka Sarin

  • Caveolin-1 and -2 in the exocytic pathway of MDCK cells.

    P. Scheiffele;P. Verkade;A.M. Fra;H. Virta

  • DIFFERENT REQUIREMENTS FOR NSF, SNAP, AND RAB PROTEINS IN APICAL AND BASOLATERAL TRANSPORT IN MDCK CELLS

    Elina Ikonen;Mitsuo Tagaya;Oliver Ullrich;Cesare Montecucco

  • Seipin regulates ER-lipid droplet contacts and cargo delivery.

    Veijo T Salo;Veijo T Salo;Ilya Belevich;Shiqian Li;Shiqian Li;Leena Karhinen

  • Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

    Sanna Heino;Sari Lusa;Pentti Somerharju;Christian Ehnholm

  • BODIPY-Cholesterol: A New Tool to Visualize Sterol Trafficking in Living Cells and Organisms

    Maarit Hölttä-Vuori;Riikka-Liisa Uronen;Jarmila Repakova;Emppu Salonen

  • Mechanisms for cellular cholesterol transport : Defects and human disease

    Elina Ikonen

  • The OSBP-related protein family in humans

    Markku Lehto;Saara Laitinen;Giulia Chinetti;Marie Johansson

  • Protein and lipid sorting from the trans-Golgi network to the plasma membrane in polarized cells

    Elina Ikonen;Kai Simons

  • Dynamic association of human insulin receptor with lipid rafts in cells lacking caveolae

    Saara Vainio;Sanna Heino;Jan-Eric Månsson;Pam Fredman

  • Prohibitin, an antiproliferative protein, is localized to mitochondria

    Elina Ikonen;Klaus Fiedler;Robert G. Parton;Kai Simons

  • Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.

    Jaspreet Sandhu;Shiqian Li;Shiqian Li;Louise Fairall;Simon G. Pfisterer;Simon G. Pfisterer

  • Zebrafish: gaining popularity in lipid research.

    Maarit Hölttä-Vuori;Veijo T. V. Salo;Lena Nyberg;Christian Brackmann

Frequent Co-Authors

Vesa M. Olkkonen
Vesa M. Olkkonen University of Helsinki
Kai Simons
Kai Simons Lipotype
Eija Jokitalo
Eija Jokitalo University of Helsinki
Johan Peränen
Johan Peränen University of Helsinki
Robert Bittman
Robert Bittman City University of New York
Leena Peltonen
Leena Peltonen University of Helsinki
Pentti Somerharju
Pentti Somerharju University of Helsinki
Ann-Christine Syvänen
Ann-Christine Syvänen Uppsala University
Robert G. Parton
Robert G. Parton University of Queensland
Anu Jalanko
Anu Jalanko University of Helsinki

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