Tania F. Gendron

Overview

Best Publications

• Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS

  Peter E.A. Ash;Kevin F. Bieniek;Tania F. Gendron;Thomas Caulfield

  1229
  Citations

• Targeting RNA Foci in iPSC-Derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion

  Dhruv Sareen;Jacqueline G. O’Rourke;Pratap Meera;A. K. M. G. Muhammad

  779
  Citations

• Aberrant Cleavage of TDP-43 Enhances Aggregation and Cellular Toxicity

  Yong Jie Zhang;Ya Fei Xu;Casey Cook;Tania F. Gendron

  720
  Citations

• Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice

  Ya Fei Xu;Tania F. Gendron;Yong Jie Zhang;Wen Lang Lin

  653
  Citations

• Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS

  Tania F Gendron;Kevin F. Bieniek;Yong-Jie Zhang;Karen Jansen-West

  633
  Citations

• The role of tau in neurodegeneration

  Tania F Gendron;Leonard Petrucelli

  609
  Citations

• Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

  Jie Jiang;Jie Jiang;Qiang Zhu;Tania F. Gendron;Shahram Saberi

  574
  Citations

• C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

  Jeannie Chew;Tania F. Gendron;Mercedes Prudencio;Hiroki Sasaguri

  464
  Citations

• Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

  Mercedes Prudencio;Veronique V Belzil;Ranjan Batra;Christian A Ross

  422
  Citations

• Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons.

  Rodrigo Lopez-Gonzalez;Yubing Lu;Tania F. Gendron;Anna Karydas

  408
  Citations

• Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS

  Zhaoming Su;Yongjie Zhang;Tania F. Gendron;Peter O. Bauer

  386
  Citations

• Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons

  Sandra Almeida;Eduardo Gascon;Hélène Tran;Hsin Jung Chou

  376
  Citations

• Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

  Yong Jie Zhang;Karen Jansen-West;Ya Fei Xu;Tania F. Gendron

  355
  Citations

• Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood.

  Veronique V. Belzil;Peter O Bauer;Mercedes Prudencio;Tania F Gendron

  335
  Citations

• Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression.

  Tadanori Hamano;Tania F. Gendron;Ena Causevic;Shu Hui Yen

  329
  Citations

• C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

  Yong Jie Zhang;Tania F. Gendron;Jonathan C. Grima;Hiroki Sasaguri

  311
  Citations

• Amyotrophic Lateral Sclerosis: An Update for 2018

  Bjorn E Oskarsson;Tania F. Gendron;Nathan P. Staff

  289
  Citations

• Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

  Yong Jie Zhang;Tania F. Gendron;Mark T.W. Ebbert;Aliesha D. O’Raw

  284
  Citations

• Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

  Casey Cook;Yari Carlomagno;Tania F. Gendron;Judy Dunmore

  281
  Citations

• Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice

  Owen Morgan Peters;Gabriela Toro Cabrera;Helene Tran;Tania F. Gendron

  276
  Citations