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Neuroscience

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134
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82159
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241
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151

Medicine

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135
Citations
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Research.com Recognitions

  • 1997 - Sheila Essey Award for ALS Research, American Academy of Neurology
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Jeffrey D. Rothstein is affiliated with Johns Hopkins University in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on several subfields including Neurology, Molecular Biology, Genetics, Cellular and Molecular Neuroscience, and Physiology.

Their scientific contributions concentrate on key topics such as Amyotrophic Lateral Sclerosis Research, Neurogenetic and Muscular Disorders Research, RNA Research and Splicing, Nuclear Structure and Function, Parkinson's Disease Mechanisms and Treatments, Mitochondrial Function and Pathology, and Neuroinflammation and Neurodegeneration Mechanisms.

Frequent publication venues for Rothstein include bioRxiv (Cold Spring Harbor Laboratory), Neuron, Acta Neuropathologica Communications, Science Translational Medicine, and Cell Reports. This reflects an engagement with both preprint and peer-reviewed journals in neuroscience and molecular biology.

Selected recent papers demonstrate a focus on neurodegeneration and cellular mechanisms related to neurological disorders:

  • Reactive astrocyte nomenclature, definitions, and future directions, 2021, Nature Neuroscience
  • Metabolic support of tumour-infiltrating regulatory T cells by lactic acid, 2021, Nature
  • G4C2 Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD, 2020, Neuron
  • Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS, 2021, Science Translational Medicine
  • C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import, 2020, eLife

Throughout their career, Rothstein has collaborated frequently with several co-authors, including Alyssa N. Coyne, Benjamin L. Zaepfel, Lindsey R. Hayes, Clive N. Svendsen, and Dhruv Sareen. These collaborations reflect a consistent engagement with experts in related research fields, particularly in neurodegenerative disease studies.

Among awards and recognitions, Rothstein has received the Sheila Essey Award for ALS Research from the American Academy of Neurology in 1997, and is a member of the Association of American Physicians.

Best Publications

  • A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD

    Alan E. Renton;Elisa Majounie;Adrian James Waite;Javier Simón-Sánchez;Javier Simón-Sánchez

  • Knockout of Glutamate Transporters Reveals a Major Role for Astroglial Transport in Excitotoxicity and Clearance of Glutamate

    Jeffrey D Rothstein;Margaret Dykes-Hoberg;Carlos A Pardo;Lynn A Bristol

  • Identification of a unique TGF-β–dependent molecular and functional signature in microglia

    Oleg Butovsky;Mark P Jedrychowski;Craig S Moore;Ron Cialic

  • Reactive astrocyte nomenclature, definitions, and future directions

    Carole Escartin;Elena Galea;András Lakatos;James P. O’Callaghan

  • Localization of neuronal and glial glutamate transporters

    Jeffrey D. Rothstein;Lee Martin;Allan I. Levey;Margaret Dykes-Hoberg

  • Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis.

    Jeffrey D. Rothstein;Marleen Van Kammen;Allan I. Levey;Lee J. Martin

  • β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression

    Jeffrey D. Rothstein;Sarjubhai Patel;Melissa R. Regan;Christine Haenggeli

  • Oligodendroglia metabolically support axons and contribute to neurodegeneration

    Youngjin Lee;Brett M. Morrison;Yun Li;Sylvain Lengacher

  • From charcot to lou gehrig: deciphering selective motor neuron death in als

    Don W. Cleveland;Jeffrey D. Rothstein

  • ALS-Linked SOD1 Mutant G85R Mediates Damage to Astrocytes and Promotes Rapidly Progressive Disease with SOD1-Containing Inclusions

    L. I. Bruijn;M. W. Becher;M. K. Lee;K. L. Anderson

  • Decreased Glutamate Transport by the Brain and Spinal Cord in Amyotrophic Lateral Sclerosis

    Jeffrey D. Rothstein;Lee J. Martin;Ralph W. Kuncl

  • Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

    Janel O. Johnson;Jessica Mandrioli;Michael Benatar;Yevgeniya Abramzon

  • Metabolic support of tumour-infiltrating regulatory T cells by lactic acid.

    McLane L.J. Watson;Paolo D.A. Vignali;Steven J. Mullett;Abigail E. Overacre-Delgoffe;Abigail E. Overacre-Delgoffe

  • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model.

    Brian K. Kaspar;Jerònia Lladó;Nushin Sherkat;Jeffrey D. Rothstein

  • Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)

    David S. Howland;Jian Liu;Yijin She;Beth Goad

  • The C9orf72 repeat expansion disrupts nucleocytoplasmic transport

    Ke Zhang;Christopher J. Donnelly;Aaron R. Haeusler;Jonathan C. Grima

  • C9orf72 nucleotide repeat structures initiate molecular cascades of disease

    Aaron R. Haeusler;Christopher J. Donnelly;Goran Periz;Eric A.J. Simko

  • Mechanisms of Disease: astrocytes in neurodegenerative disease.

    Nicholas J Maragakis;Jeffrey D Rothstein

  • RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention

    Christopher J. Donnelly;Ping-Wu Zhang;Jacqueline T. Pham;Aaron R. Haeusler

  • NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration

    Shin H. Kang;Masahiro Fukaya;Jason K. Yang;Jeffrey D. Rothstein

  • Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis

    Jeffrey D. Rothstein;Guochuan Tsai;Ralph W. Kuncl;Lora Clawson

  • Erratum: Identification of a unique TGF-β-dependent molecular and functional signature in microglia (Nature Neuroscience (2014) 17 (131-143))

    Oleg Butovsky;Mark P. Jedrychowski;Craig S. Moore;Ron Cialic

Frequent Co-Authors

Merit Cudkowicz
Merit Cudkowicz Harvard University
Bryan J. Traynor
Bryan J. Traynor National Institutes of Health
Jonathan D. Glass
Jonathan D. Glass Emory University
Orla Hardiman
Orla Hardiman Trinity College Dublin
Dwight E. Bergles
Dwight E. Bergles Johns Hopkins University
Michael J. Strong
Michael J. Strong University of Michigan–Ann Arbor
Robert G. Miller
Robert G. Miller California Pacific Medical Center
James A. Russell
James A. Russell Boston College
Michael B. Robinson
Michael B. Robinson Children's Hospital of Philadelphia
J. Raphael Gibbs
J. Raphael Gibbs National Institutes of Health

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