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Best Female Scientists
2025

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Best Female Scientists

D-Index
127
Citations
55413
World Ranking
403
National Ranking
40

Medicine

D-Index
128
Citations
59707
World Ranking
2719
National Ranking
281

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2001 - Sheila Essey Award for ALS Research, American Academy of Neurology

Overview

Pamela J. Shaw is affiliated with the University of Sheffield in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a particular focus on Neurology, Genetics, and Molecular Biology as subfields of study.

The main topics of their work include Amyotrophic Lateral Sclerosis (ALS) Research, Neurogenetic and Muscular Disorders Research, Neurological Diseases and Metabolism, Parkinson's Disease Mechanisms and Treatments, Alzheimer's Disease Research and Treatments, RNA Research and Splicing, and Genetic Neurodegenerative Diseases.

Recent publications by Pamela J. Shaw cover a range of clinically relevant and research-intensive studies. Notable papers include:

  • Amyotrophic lateral sclerosis, 2022, The Lancet
  • Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS, 2022, New England Journal of Medicine
  • Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS, 2020, New England Journal of Medicine
  • Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology, 2021, Nature Genetics
  • Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation, 2022, Nature Reviews Drug Discovery

Frequent co-authors collaborating with Shaw include Johnathan Cooper-Knock, Ammar Al-Chalabi, Jan H. Veldink, Alfredo Iacoangeli, and Orla Hardiman.

Shaw has contributed extensively to several key publication venues, demonstrating consistent involvement in the academic dissemination of research findings. These venues include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  • Journal of Neurology Neurosurgery & Psychiatry
  • Brain
  • Brain Communications

Among professional recognitions, Shaw has been named a Fellow of the American Association for the Advancement of Science (AAAS) in 2015 and received the Sheila Essey Award for ALS Research from the American Academy of Neurology in 2001.

Best Publications

  • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study

    Elisa Majounie;Alan E. Renton;Kin Mok;Elise G. P. Dopper;Elise G. P. Dopper

  • Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

    Ian R.A. Mackenzie;Eileen H. Bigio;Paul G. Ince;Felix Geser

  • Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial.

    Stephen C Bourke;Mark Tomlinson;Tim L Williams;Robert E Bullock

  • Adaptation to culture of human embryonic stem cells and oncogenesis in vivo

    Duncan E C Baker;Neil J Harrison;Edna Maltby;Kath Smith

  • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

    Laura Ferraiuolo;Janine Kirby;Andrew J. Grierson;Michael Sendtner

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Oxidative stress in ALS: key role in motor neuron injury and therapeutic target.

    Siân C. Barber;Pamela J. Shaw

  • White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

    Malee S. Fernando;Julie E. Simpson;Fiona Matthews;Carol Brayne

  • Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions

    Vivianna M. Van Deerlin;Patrick M A Sleiman;Maria Martinez-Lage;Maria Martinez-Lage;Alice Chen-Plotkin

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Controversies and priorities in amyotrophic lateral sclerosis

    Martin R Turner;Orla Hardiman;Michael Benatar;Benjamin R Brooks

  • Neurologic and neuropsychological morbidity following major surgery: comparison of coronary artery bypass and peripheral vascular surgery.

    P J Shaw;D Bates;N E Cartlidge;J M French

  • Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target

    Siân C. Barber;Richard J. Mead;Pamela J. Shaw

  • Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model

    Henk Jan Westeneng;Thomas P.A. Debray;Anne E. Visser;Ruben P.A. van Eijk

  • ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

    N. Parkinson;P. G. Ince;M. O. Smith;R. Highley

  • The role of mitochondria in amyotrophic lateral sclerosis

    Emma F. Smith;Pamela J. Shaw;Kurt J. De Vos

  • Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

    Kurt J. De Vos;Kurt J. De Vos;Anna L. Chapman;Maria E. Tennant;Catherine Manser

  • C9ORF72 GGGGCC Expanded Repeats Produce Splicing Dysregulation which Correlates with Disease Severity in Amyotrophic Lateral Sclerosis.

    Johnathan Cooper-Knock;Joanna J. Bury;Paul R Heath;Matthew Wyles

  • Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death.

    Gillian M. Borthwick;Margaret A. Johnson;Paul G. Ince;Pamela J. Shaw

  • Early neurological complications of coronary artery bypass surgery.

    P. J. Shaw;D. Bates;N. E. F. Cartlidge;D. Heaviside

Frequent Co-Authors

Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Paul G. Ince
Paul G. Ince University of Sheffield
Karen E. Morrison
Karen E. Morrison University of Southampton
Christopher Shaw
Christopher Shaw King's College London
Orla Hardiman
Orla Hardiman Trinity College Dublin
Kevin Talbot
Kevin Talbot University of Oxford
Martin R. Turner
Martin R. Turner University of Oxford
Jan H. Veldink
Jan H. Veldink Utrecht University
Leonard H. van den Berg
Leonard H. van den Berg Utrecht University
John Landers
John Landers University of Massachusetts Chan Medical School

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