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Genetics

D-Index
67
Citations
18252
World Ranking
2519
National Ranking
1126

Overview

John Landers is affiliated with the University of Massachusetts Chan Medical School in the United States. Their research spans primarily the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to related subfields including Neurology, Genetics, Molecular Biology, Cell Biology, and Physiology.

Their research topics focus notably on Amyotrophic Lateral Sclerosis (ALS) Research, Neurogenetic and Muscular Disorders, Neurological Diseases and Metabolism, RNA research and splicing, Parkinson's Disease mechanisms and treatments, Cancer-related gene regulation, and Alzheimer's disease research and treatments.

Recent publications by John Landers include the following:

  • Genome-wide meta-analysis identifies 127 open-angle glaucoma loci with consistent effect across ancestries, 2021, Nature Communications
  • Amyotrophic lateral sclerosis: translating genetic discoveries into therapies, 2023, Nature Reviews Genetics
  • Genome-wide identification of the genetic basis of amyotrophic lateral sclerosis, 2022, Neuron
  • Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway, 2021, Nature Neuroscience
  • ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function, 2022, Cell Reports

John Landers frequently collaborates with other researchers in the field. Their most frequent co-authors are:

  • Jan H. Veldink
  • Pamela J. Shaw
  • Ammar Al-Chalabi
  • Vincenzo Silani
  • Nicola Ticozzi

The main publication venues for their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Brain
  • Cell Reports
  • Science Advances

Best Publications

  • Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.

    T. J. Kwiatkowski;D. A. Bosco;D. A. Bosco;A. L. LeClerc;A. L. LeClerc;E. Tamrazian

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Mutations in the Profilin 1 Gene Cause Familial Amyotrophic Lateral Sclerosis

    Chi Hong Wu;Claudia Fallini;Nicola Ticozzi;Pamela J. Keagle

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Deleterious Variants of FIG4, a Phosphoinositide Phosphatase, in Patients with ALS

    Clement Y. Chow;John E. Landers;John E. Landers;Sarah K. Bergren;Peter C. Sapp;Peter C. Sapp;Peter C. Sapp

  • Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.

    Michael A van Es;Jan H Veldink;Christiaan G J Saris;Hylke M Blauw

  • Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

    Kathryn P Burdon;Stuart Macgregor;Alex W Hewitt;Alex W Hewitt;Shiwani Sharma

  • Exome-wide rare variant analysis identifies TUBA4A mutations associated with familial ALS.

    B N Smith;N Ticozzi;C Fallini;A S Gkazi

  • Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

    Claire L. Simpson;Robin Lemmens;Robin Lemmens;Katarzyna Miskiewicz;Katarzyna Miskiewicz;Wendy J. Broom

  • NEK1 variants confer susceptibility to amyotrophic lateral sclerosis

    Kevin P Kenna;Perry T C van Doormaal;Annelot M Dekker;Nicola Ticozzi

  • Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

    John E. Landers;Suzanne L. Cassel;Donna L. George

  • The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder.

    Bradley N. Smith;Stephen Newhouse;Aleksey Shatunov;Caroline Vance

  • Multitrait analysis of glaucoma identifies new risk loci and enables polygenic prediction of disease susceptibility and progression

    Jamie E. Craig;Xikun Han;Xikun Han;Ayub Qassim;Mark Hassall

  • Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study

    Aleksey Shatunov;Kin Mok;Stephen Newhouse;Michael E Weale

  • Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis

    John E. Landers;Judith Melki;Vincent Meininger;Jonathan D. Glass

  • Common variants near ABCA1, AFAP1 and GMDS confer risk of primary open-angle glaucoma

    Puya Gharahkhani;Kathryn P. Burdon;Kathryn P. Burdon;Rhys Fogarty;Shiwani Sharma

  • Common and rare variant association analyses in Amyotrophic Lateral Sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

    Wouter van Rheenen;Rick A. A. van der Spek;Mark K. Bakker;Joke J. F. A. van Vugt

  • Genome-Wide Analyses Identify KIF5A as a Novel ALS Gene

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Nicola Ticozzi

  • Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1

    K. P. Burdon;S. MacGregor;A. W. Hewitt;S. Sharma

Frequent Co-Authors

Jamie E. Craig
Jamie E. Craig Flinders University
Alex W. Hewitt
Alex W. Hewitt University of Tasmania
Ammar Al-Chalabi
Ammar Al-Chalabi King's College London
Orla Hardiman
Orla Hardiman Trinity College Dublin
Christopher Shaw
Christopher Shaw King's College London
David A. Mackey
David A. Mackey University of Western Australia
Kathryn P. Burdon
Kathryn P. Burdon University of Tasmania
Jan H. Veldink
Jan H. Veldink Utrecht University
Karen E. Morrison
Karen E. Morrison University of Southampton
Leonard H. van den Berg
Leonard H. van den Berg Utrecht University

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