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Medicine

D-Index
110
Citations
64607
World Ranking
5435
National Ranking
537

Research.com Recognitions

  • 2016 - Sheila Essey Award for ALS Research, American Academy of Neurology

Overview

Ammar Al-Chalabi is affiliated with King's College London in the United Kingdom. Their research primarily spans the fields of medicine and biochemistry, genetics, and molecular biology, with significant contributions in neurology, genetics, molecular biology, physiology, and cellular and molecular neuroscience.

The primary focus of their work lies in amyotrophic lateral sclerosis (ALS) research, neurogenetic and muscular disorders, Parkinson's disease mechanisms and treatments, neurological diseases and metabolism, prion diseases and protein misfolding, genetic associations and epidemiology, and genetic neurodegenerative diseases.

Frequent publication venues for Ammar Al-Chalabi include:

  • Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Brain
  • Journal of Neurology Neurosurgery & Psychiatry
  • Brain Communications

Notable recent papers include:

  • "A multicentre validation study of the diagnostic value of plasma neurofilament light," 2021, Nature Communications
  • "A proposal for new diagnostic criteria for ALS," 2020, Clinical Neurophysiology
  • "Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation," 2021, Nature Genetics
  • "Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis," 2022, The Lancet Neurology
  • "Improving clinical trial outcomes in amyotrophic lateral sclerosis," 2020, Nature Reviews Neurology

Frequent co-authors include Alfredo Iacoangeli, Ahmad Al Khleifat, Pamela J. Shaw, Orla Hardiman, and Jan H. Veldink.

The scientist received the Sheila Essey Award for ALS Research from the American Academy of Neurology in 2016.

Best Publications

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

    Jemeen Sreedharan;Ian P. Blair;Vineeta B. Tripathi;Xun Hu

  • Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

    Caroline Vance;Boris Rogelj;Tibor Hortobágyi;Kurt J. De Vos

  • Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease (Nature Genetics (2009) 41 (1088-1093))

    D Harold;R Abraham;P Hollingworth;R Sims

  • Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.

    Paul Hollingworth;Denise Harold;Rebecca Sims;Amy Gerrish

  • Analysis of shared heritability in common disorders of the brain

    Verneri Anttila;Verneri Anttila;Brendan Bulik-Sullivan;Brendan Bulik-Sullivan;Hilary K. Finucane;Raymond K. Walters;Raymond K. Walters

  • VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

    Diether Lambrechts;Erik Storkebaum;Masafumi Morimoto;Jurgen Del-Favero

  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

    Rebecca Sims;Sven J. Van Der Lee;Adam C. Naj;Céline Bellenguez;Céline Bellenguez

  • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

    Elizabeth T. Cirulli;Brittany N Lasseigne;Slave Petrovski;Peter C Sapp

  • The epidemiology of ALS: a conspiracy of genes, environment and time

    Ammar Al-Chalabi;Orla Hardiman

  • Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

    Lesley Jones;Peter A. Holmans;Marian L. Hamshere;Denise Harold

  • Clinical genetics of amyotrophic lateral sclerosis: what do we really know?

    Peter M. Andersen;Ammar Al-Chalabi

  • Genome-wide Analyses Identify KIF5A as a Novel ALS Gene.

    Aude Nicolas;Kevin P. Kenna;Alan E. Renton;Alan E. Renton;Nicola Ticozzi

  • Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis

    Wouter van Rheenen;Aleksey Shatunov;Annelot M. Dekker;Russell L. McLaughlin

  • Cognitive and clinical characteristics of patients with amyotrophic lateral sclerosis carrying a C9orf72 repeat expansion: a population-based cohort study

    Susan Byrne;Susan Byrne;Marwa Elamin;Marwa Elamin;Peter Bede;Peter Bede;Aleksey Shatunov

  • p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS

    Safa Al-Sarraj;Andrew King;Claire Troakes;Bradley Smith

  • The genetics and neuropathology of amyotrophic lateral sclerosis

    Ammar Al-Chalabi;Ashley Jones;Claire Troakes;Claire Troakes;Andrew King;Andrew King

  • Deletions of the Heavy Neurofilament Subunit Tail in Amyotrophic Lateral Sclerosis

    Ammar Al-Chalabi;Peter M. Andersen;Peter Nilsson;Barry Chioza

  • Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimertextquotesingles disease

    Denise Harold;Richard Abraham;Paul Hollingworth;Rebecca Sims

  • Supporting Online Material for Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

    Caroline Vance;Boris Rogelj;Tibor Hortobágyi;Kurt J. De Vos

Frequent Co-Authors

Christopher Shaw
Christopher Shaw King's College London
Orla Hardiman
Orla Hardiman Trinity College Dublin
Pamela J. Shaw
Pamela J. Shaw University of Sheffield
P. Nigel Leigh
P. Nigel Leigh Brighton and Sussex Medical School
Karen E. Morrison
Karen E. Morrison University of Southampton
Martin R. Turner
Martin R. Turner University of Oxford
Leonard H. van den Berg
Leonard H. van den Berg Utrecht University
Jan H. Veldink
Jan H. Veldink Utrecht University
John Landers
John Landers University of Massachusetts Chan Medical School
Adriano Chiò
Adriano Chiò University of Turin

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