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Jukka Westermarck

Jukka Westermarck

D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
14462
World Ranking
14841
National Ranking
102

Overview

Jukka Westermarck is affiliated with Åbo Akademi University in Finland. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with a significant emphasis on Molecular Biology and Oncology.

The scientist has published extensively in cancer-related fields, exploring molecular pathways, protein phosphatases, and cancer metabolism. Their recent contributions include detailed studies on cancer signaling and transcription regulation.

Their recent notable papers include:

  • The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer (2021, Cell)
  • Druggable cancer phosphatases (2021, Science Translational Medicine)
  • Editor's Note: p38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Inducing Dephosphorylation of Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase1,2 (2020, Cancer Research)
  • Phosphoproteome and drug-response effects mediated by the three protein phosphatase 2A inhibitor proteins CIP2A, SET, and PME-1 (2020, Journal of Biological Chemistry)
  • UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an Ubiquitin Ligase That Limits MYC-Dependent Apoptosis (2020, Cancer Research)

Frequent co-authors include:

  • Joni Merisaari
  • Karolina Pavic
  • Mukund Sharma
  • Krister Wennerberg
  • Tero Aittokallio

The scientist publishes regularly in several key venues, with the most frequent being bioRxiv (Cold Spring Harbor Laboratory) with 14 publications, followed by Cancer Research (8), Molecular Oncology (3), Cell (2), and Neurotherapeutics (2).

Their work covers various subfields of study, including Molecular Biology, Oncology, Cancer Research, Genetics, and Cell Biology. Main topics of research are:

  • Ubiquitin and proteasome pathways
  • RNA modifications and cancer
  • Cancer-related Molecular Pathways
  • Glioma Diagnosis and Treatment
  • Protein Tyrosine Phosphatases
  • Cancer, Hypoxia, and Metabolism
  • Histone Deacetylase Inhibitors Research

Best Publications

  • Regulation of matrix metalloproteinase expression in tumor invasion

    Jukka Westermarck;Veli-Matti Kähäri

  • Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

    Melissa R. Junttila;Song-Ping Li;Jukka Westermarck

  • CIP2A Inhibits PP2A in Human Malignancies

    Melissa R. Junttila;Pietri Puustinen;Minna Niemelä;Minna Niemelä;Raija Ahola

  • ColonyArea: An ImageJ Plugin to Automatically Quantify Colony Formation in Clonogenic Assays

    Camilo Guzmán;Manish Bagga;Amanpreet Kaur;Jukka Westermarck

  • Multiple pathways regulated by the tumor suppressor PP2A in transformation.

    Jukka Westermarck;William C. Hahn;William C. Hahn

  • Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression ∗

    Terhi Riikonen;Jukka Westermarck;Leeni Koivisto;Arsi Broberg

  • Integrated network analysis platform for protein-protein interactions

    Jianmin Wu;Tea Vallenius;Kristian Ovaska;Jukka Westermarck;Jukka Westermarck

  • Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.

    Nina Johansson;Ulpu Saarialho-Kere;Kristiina Airola;Riitta Herva

  • Enhancement of Fibroblast Collagenase (Matrix Metalloproteinase-1)Gene Expression by Ceramide Is Mediated by Extracellular Signal-regulated and Stress-activated Protein Kinase Pathways

    Niina Reunanen;Jukka Westermarck;Lari Häkkinen;Tim H. Holmström

  • CIP2A Is Associated with Human Breast Cancer Aggressivity

    Christophe Côme;Anni Laine;Maïa Chanrion;Henrik Edgren

  • Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail

    Johanna Ivaska;Hilkka Reunanen;Jukka Westermarck;Leeni Koivisto

  • MYC-Dependent Regulation and Prognostic Role of CIP2A in Gastric Cancer

    Anchit Khanna;Camilla Böckelman;Annabrita Hemmes;Melissa R. Junttila

  • p38 mitogen-activated protein kinase-dependent activation of protein phosphatases 1 and 2A inhibits MEK1 and MEK2 activity and collagenase 1 (MMP-1) gene expression

    Jukka Westermarck;Song-Ping Li;Tuula Kallunki;Jiahuai Han

  • Large-scale data integration framework provides a comprehensive view on glioblastoma multiforme

    Kristian Ovaska;Marko Laakso;Saija Haapa-Paananen;Riku Louhimo

  • Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.

    Jouko Lohi;Kaisa Lehti;Jukka Westermarck;Veli‐Matti Kähäri

  • Differential regulation of interstitial collagenase (MMP-1) gene expression by ETS transcription factors

    Jukka Westermarck;Arun Seth;Veli-Matti Kähäri

  • Mechanisms of MYC stabilization in human malignancies

    Melissa R. Junttila;Jukka Westermarck

  • Cancerous Inhibitor of Protein Phosphatase 2A, an Emerging Human Oncoprotein and a Potential Cancer Therapy Target

    Anchit Khanna;John E. Pimanda;Jukka Westermarck

  • Single‐step Strep‐tag® purification for the isolation and identification of protein complexes from mammalian cells

    Melissa R. Junttila;Melissa R. Junttila;Susanna Saarinen;Thomas Schmidt;Juergen Kast

  • p38α and p38δ mitogen-activated protein kinase isoforms regulate invasion and growth of head and neck squamous carcinoma cells

    Junttila Mr;Ala-Aho R;Jokilehto T;Jokilehto T;Peltonen J

Frequent Co-Authors

Veli-Matti Kähäri
Veli-Matti Kähäri Turku University Hospital
Tero Aittokallio
Tero Aittokallio University of Helsinki
Ari Ristimäki
Ari Ristimäki University of Helsinki
Johanna Ivaska
Johanna Ivaska University of Turku
Jyrki Heino
Jyrki Heino University of Turku
Reidar Grénman
Reidar Grénman Turku University Hospital
Heikki Joensuu
Heikki Joensuu University of Helsinki
Caj Haglund
Caj Haglund University of Helsinki
Jorma Toppari
Jorma Toppari University of Turku
Riitta Lahesmaa
Riitta Lahesmaa Åbo Akademi University

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