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D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
15084
World Ranking
6772
National Ranking
52

Overview

Jyrki Heino is affiliated with the University of Turku in Finland. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on Molecular Biology, Oncology, Immunology, Immunology and Allergy, and Cancer Research as subfields.

The main topics explored in their work include Cell Adhesion Molecules Research, Immunotherapy and Immune Responses, Ubiquitin and proteasome pathways, Collagen: Extraction and Characterization, Melanoma and MAPK Pathways, Cancer Immunotherapy and Biomarkers, and Nonmelanoma Skin Cancer Studies.

Significant recent publications by Jyrki Heino include:

  • Unravelling the proteomic landscape of extracellular vesicles in prostate cancer by density-based fractionation of urine (2020), published in Journal of Extracellular Vesicles
  • MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity (2021), published in Nature Methods
  • Feasibility of Mechanical Extrusion to Coat Nanoparticles with Extracellular Vesicle Membranes (2020), published in Cells
  • C1r Upregulates Production of Matrix Metalloproteinase-13 and Promotes Invasion of Cutaneous Squamous Cell Carcinoma (2021), published in Journal of Investigative Dermatology
  • Interaction between prostate cancer cells and prostate fibroblasts promotes accumulation and proteolytic processing of basement membrane proteins (2020), published in The Prostate

Jyrki Heino's frequent coauthors include Pekka Rappu, Elina Siljamäki, Pilvi Riihilä, Olivier De Wever, and Ujjwal Suwal.

Their work has been published frequently in venues such as Journal of Investigative Dermatology, bioRxiv (Cold Spring Harbor Laboratory), Cancer Research, Matrix Biology, and Nature Protocols.

Best Publications

  • The collagen family members as cell adhesion proteins

    Jyrki Heino

  • Integrin-mediated cell adhesion to type I collagen fibrils.

    Johanna Jokinen;Elina Dadu;Petri Nykvist;Jarmo Käpylä

  • Integrin α2β1 Is a Positive Regulator of Collagenase (MMP-1) and Collagen α1(I) Gene Expression ∗

    Terhi Riikonen;Jukka Westermarck;Leeni Koivisto;Arsi Broberg

  • Induction of Collagenase-3 (MMP-13) Expression in Human Skin Fibroblasts by Three-dimensional Collagen Is Mediated by p38 Mitogen-activated Protein Kinase

    Laura Ravanti;Jyrki Heino;Jyrki Heino;Carlos López-Otı́n;Veli-Matti Kähäri

  • Collagenase-3 (MMP-13) is expressed by hypertrophic chondrocytes, periosteal cells, and osteoblasts during human fetal bone development.

    Nina Johansson;Ulpu Saarialho-Kere;Kristiina Airola;Riitta Herva

  • Entry of Coxsackievirus A9 into Host Cells: Specific Interactions with αvβ3 Integrin, the Vitronectin Receptor

    Merja Roivainen;Liisa Piirainen;Tapani Hovi;Ismo Virtanen

  • Internalization of Echovirus 1 in Caveolae

    Varpu Marjomäki;Vilja Pietiäinen;Heli Matilainen;Paula Upla

  • Selective Binding of Collagen Subtypes by Integrin α1I, α2I, and α10I Domains

    Mira Tulla;Olli T. Pentikäinen;Tiina Viitasalo;Jarmo Käpylä

  • Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic Tail

    Johanna Ivaska;Hilkka Reunanen;Jukka Westermarck;Leeni Koivisto

  • Cooperation Between Integrins and Growth Factor Receptors in Signaling and Endocytosis

    Johanna Ivaska;Jyrki Heino

  • Transforming growth factor-beta switches the pattern of integrins expressed in MG-63 human osteosarcoma cells and causes a selective loss of cell adhesion to laminin.

    J Heino;J Massagué

  • BioImageXD: an open, general-purpose and high-throughput image-processing platform

    Pasi Kankaanpää;Lassi Paavolainen;Silja Tiitta;Mikko Karjalainen

  • Adhesion receptors and cell invasion: mechanisms of integrin-guided degradation of extracellular matrix.

    J. Ivaska;J. Heino

  • Distinct Recognition of Collagen Subtypes by α1β1 and α2β1Integrins α1β1 MEDIATES CELL ADHESION TO TYPE XIII COLLAGEN

    Petri Nykvist;Hongmin Tu;Johanna Ivaska;Jarmo Käpylä

  • Clustering Induces a Lateral Redistribution of α2β1 Integrin from Membrane Rafts to Caveolae and Subsequent Protein Kinase C-dependent Internalization

    Paula Upla;Varpu Marjomäki;Pasi Kankaanpää;Johanna Ivaska

  • Integrins in Wound Healing

    Leeni Koivisto;Jyrki Heino;Lari Häkkinen;Hannu Larjava

  • α11β1 Integrin Recognizes the GFOGER Sequence in Interstitial Collagens

    Wan-Ming Zhang;Jarmo Käpylä;J. Santeri Puranen;C. Graham Knight

  • Regulation of integrin-type cell adhesion receptors by cytokines.

    P Santala;J Heino

  • Transforming Growth Factor-β Regulates Collagen Gel Contraction by Increasing α2β1 Integrin Expression in Osteogenic Cells (∗)

    Terhi Riikonen;Leeni Koivisto;Pia Vihinen;Jyrki Heino

  • Comparative Effects of Interleukin-1 and Tumor Necrosis Factor-α on Collagen Production and Corresponding Procollagen mRNA Levels in Human Dermal Fibroblasts

    Alain Mauviel;Jyrki Heino;Veli-Matti Kähäri;Daniel-Jean Hartmann

Frequent Co-Authors

Veli-Matti Kähäri
Veli-Matti Kähäri Turku University Hospital
Hannu Larjava
Hannu Larjava University of British Columbia
Johanna Ivaska
Johanna Ivaska University of Turku
Timo Hyypiä
Timo Hyypiä University of Turku
Eero Vuorio
Eero Vuorio University of Turku
Jukka Westermarck
Jukka Westermarck Åbo Akademi University
Olivier De Wever
Olivier De Wever Ghent University
Markku Jalkanen
Markku Jalkanen Faron Pharmaceuticals
Donald Gullberg
Donald Gullberg University of Bergen
Johannes A. Eble
Johannes A. Eble University of Münster

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