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Biology and Biochemistry

D-Index
61
Citations
10522
World Ranking
11579
National Ranking
51

Overview

Yih-Shou Hsieh is a scientist affiliated with Chung Shan Medical University in Taiwan. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Within these broad areas, their work focuses on subfields such as Molecular Biology, Complementary and Alternative Medicine, Immunology and Allergy, Cancer Research, and Plant Science.

The scientist's publications reflect their diverse interest in cellular and molecular mechanisms related to health and disease. Their recent papers include:

  • Gossypol Reduces Metastasis and Epithelial-Mesenchymal Transition by Targeting Protease in Human Cervical Cancer, 2020, The American Journal of Chinese Medicine
  • Carbonic Anhydrase III Promotes Cell Migration and Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma, 2020, Cells
  • The Inhibitory Effects of Terminalia catappa L. Extract on the Migration and Invasion of Human Glioblastoma Multiforme Cells, 2021, Pharmaceuticals
  • Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro, 2022, Frontiers in Pharmacology
  • Corrigendum: Terminalia catappa leaf extracts inhibited metastasis of A2058 and A375 melanoma cells via downregulating p-Src and β-catenin pathway in vitro, 2022, Frontiers in Pharmacology

These publications demonstrate a significant engagement with cancer-related cellular processes, especially focusing on metastasis, epithelial-mesenchymal transition, and the effects of plant-derived compounds on these mechanisms.

The primary research topics covered by Yih-Shou Hsieh include:

  • Cell Adhesion Molecules Research
  • Phytochemicals and Medicinal Plants
  • Bioactive Compounds in Plants
  • Ubiquitin and proteasome pathways
  • Chronic Lymphocytic Leukemia Research
  • Enzyme function and inhibition
  • Synthesis and Catalytic Reactions

The frequent co-authors in their body of work are Pei-Ni Chen, Shu-Chen Chu, Chiao-Wen Lin, Shun-Fa Yang, and Chin-Kuo Chang. Collaborative publishing venues include Frontiers in Pharmacology, The American Journal of Chinese Medicine, Cells, Pharmaceuticals, and Drug Development Research.

The research conducted by Yih-Shou Hsieh reflects interdisciplinary integration, involving the study of molecular pathways, plant-based bioactive substances, and their potential therapeutic roles in cancer and other diseases. This approach aligns with their focus on complementary and alternative medicine, in addition to conventional biomedical research.

Best Publications

  • Mulberry anthocyanins, cyanidin 3-rutinoside and cyanidin 3-glucoside, exhibited an inhibitory effect on the migration and invasion of a human lung cancer cell line.

    Pei-Ni Chen;Shu-Chen Chu;Hui-Ling Chiou;Wu-Hsien Kuo

  • Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo.

    Pei-Ni Chen;Shu-Chen Chu;Hui-Ling Chiou;Chui-Liang Chiang

  • Black rice anthocyanins inhibit cancer cells invasion via repressions of MMPs and u-PA expression.

    Pei-Ni Chen;Wu-Hsien Kuo;Chui-Liang Chiang;Hui-Ling Chiou

  • Silibinin inhibits cell invasion through inactivation of both PI3K-Akt and MAPK signaling pathways.

    Pei-Ni Chen;Yih-Shou Hsieh;Hui-Ling Chiou;Shu-Chen Chu

  • Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2.

    Shu-Chen Chu;Hui-Ling Chiou;Pei-Ni Chen;Shun-Fa Yang

  • Berberine induces apoptosis in SW620 human colonic carcinoma cells through generation of reactive oxygen species and activation of JNK/p38 MAPK and FasL

    Wen-Hsiu Hsu;Yih-Shou Hsieh;Hsing-Chun Kuo;Chun-Yuh Teng

  • Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1

    Chia-Jui Weng;Chi-Fai Chau;Yih-Shou Hsieh;Shun-Fa Yang

  • Inhibitory effect of berberine on tert-butyl hydroperoxide-induced oxidative damage in rat liver.

    Jin-Ming Hwang;Chau-Jong Wang;Feu-Pi Chou;Tsui-Hwa Tseng

  • Inhibitory effect of berberine on the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2

    Pei-Ling Peng;Yih-Shou Hsieh;Chau-Jong Wang;Jui-Ling Hsu

  • Regulation of matrix metalloproteinase production by cytokines, pharmacological agents and periodontal pathogens in human periodontal ligament fibroblast cultures.

    Yu Chao Chang;Shun Fa Yang;Chung Chih Lai;Jer Yuh Liu

  • p38 Mitogen-Activated Protein Kinase Pathway Is Involved in Protein Kinase Cα–Regulated Invasion in Human Hepatocellular Carcinoma Cells

    Yi Hsien Hsieh;Trang Tiau Wu;Chih Yang Huang;Yih Shou Hsieh

  • Silibinin Inhibits Invasion of Oral Cancer Cells by Suppressing the MAPK Pathway

    P.-N. Chen;Y.-S. Hsieh;C.-L. Chiang;H.-L. Chiou

  • Increased tissue inhibitor of metalloproteinase-1 expression and inhibition of gelatinase A activity in buccal mucosal fibroblasts by arecoline as possible mechanisms for oral submucous fibrosis

    Yu-Chao Chang;Shun-Fa Yang;Kuo-Wei Tai;Ming-Yung Chou

  • Silibinin suppresses human osteosarcoma MG-63 cell invasion by inhibiting the ERK-dependent c-Jun/AP-1 induction of MMP-2.

    Yih-Shou Hsieh;Shu-Chen Chu;Shun-Fa Yang;Pei-Ni Chen

  • Dioscin-induced autophagy mitigates cell apoptosis through modulation of PI3K/Akt and ERK and JNK signaling pathways in human lung cancer cell lines.

    Ming-Ju Hsieh;Te-Lung Tsai;Te-Lung Tsai;Yih-Shou Hsieh;Chau-Jong Wang

  • Kaempferol reduces matrix metalloproteinase-2 expression by down-regulating ERK1/2 and the activator protein-1 signaling pathways in oral cancer cells.

    Chiao-Wen Lin;Pei-Ni Chen;Mu-Kuan Chen;Wei-En Yang

  • Protective effects of berberine against low-density lipoprotein (LDL) oxidation and oxidized LDL-induced cytotoxicity on endothelial cells.

    Yih-Shou Hsieh;Wu-Hsien Kuo;Ta-Wei Lin;Horng-Rong Chang

  • Carbonic anhydrase XII promotes invasion and migration ability of MDA-MB-231 breast cancer cells through the p38 MAPK signaling pathway.

    Ming-Ju Hsieh;Kuo-Shuen Chen;Hui-Ling Chiou;Yih-Shou Hsieh

  • Antimetastatic effects of Terminalia catappa L. on oral cancer via a down-regulation of metastasis-associated proteases.

    Shun-Fa Yang;Mu-Kuan Chen;Mu-Kuan Chen;Yih-Shou Hsieh;Jia-Sin Yang

  • Reduction of PKCα decreases cell proliferation, migration, and invasion of human malignant hepatocellular carcinoma

    Trang Tiau Wu;Yi Hsien Hsieh;Yih Shou Hsieh;Jer Yuh Liu

Frequent Co-Authors

Chau-Jong Wang
Chau-Jong Wang Chung Shan Medical University
Chih-Hsin Tang
Chih-Hsin Tang China Medical University
Jen-Kun Lin
Jen-Kun Lin National Taiwan University
Chong-Kuei Lii
Chong-Kuei Lii China Medical University
Gow-Chin Yen
Gow-Chin Yen National Chung Hsing University
Chang Hai Tsai
Chang Hai Tsai Asian University
Po-Huang Lee
Po-Huang Lee National Taiwan University
Gautam Sethi
Gautam Sethi National University of Singapore

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