World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
19208
World Ranking
3586
National Ranking
15

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Apoptosis
  • Enzyme

His primary areas of study are Apoptosis, Cancer cell, Molecular biology, Cell biology and Programmed cell death. Jai Sing Yang regularly links together related areas like Cancer research in his Apoptosis studies. His Cancer cell study incorporates themes from Endocrinology, Propidium iodide, Berberine, Curcumin and Squamous carcinoma.

The various areas that Jai Sing Yang examines in his Molecular biology study include Protein kinase B, Viability assay, Comet assay, PI3K/AKT/mTOR pathway and Kinase. Jai Sing Yang has included themes like Caspase and DNA fragmentation in his Cell biology study. His study in Programmed cell death is interdisciplinary in nature, drawing from both Internal medicine and Cell growth.

His most cited work include:

  • Quercetin-mediated cell cycle arrest and apoptosis involving activation of a caspase cascade through the mitochondrial pathway in human breast cancer MCF-7 cells. (188 citations)
  • Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways (176 citations)
  • Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF) (162 citations)

What are the main themes of his work throughout his whole career to date?

Jai Sing Yang focuses on Apoptosis, Molecular biology, Cancer research, Cancer cell and Cell biology. Apoptosis is a component of his Programmed cell death, Cell cycle, Viability assay, DAPI and Cytochrome c studies. His research integrates issues of Blot, Signal transduction, Comet assay, Cytotoxic T cell and Leukemia in his study of Molecular biology.

Jai Sing Yang has researched Cancer research in several fields, including Cell, Cell migration, Protein kinase B, Cell growth and Immunology. His Cancer cell research includes elements of Curcumin, Propidium iodide, MAPK/ERK pathway and Pathology. His Cell biology study combines topics in areas such as Caspase, DNA fragmentation and Cell cycle checkpoint.

He most often published in these fields:

  • Apoptosis (62.22%)
  • Molecular biology (35.56%)
  • Cancer research (31.75%)

What were the highlights of his more recent work (between 2016-2021)?

  • Cancer research (31.75%)
  • Apoptosis (62.22%)
  • Cell cycle (19.05%)

In recent papers he was focusing on the following fields of study:

Jai Sing Yang mainly focuses on Cancer research, Apoptosis, Cell cycle, Cancer cell and Viability assay. His research in Cancer research intersects with topics in Cancer, Protein kinase B, MAPK/ERK pathway, Oncogene and ATG12. His Apoptosis research integrates issues from Cell, Cell growth, Molecular biology and Cell biology.

Jai Sing Yang usually deals with Cell cycle and limits it to topics linked to Osteosarcoma and Epithelial–mesenchymal transition, Protein kinase A, Viable cell and Cantharidin. His biological study spans a wide range of topics, including TUNEL assay, AMPK, G2 m phase, Resveratrol and p38 mitogen-activated protein kinases. His Viability assay research incorporates themes from DAPI, Caspase, Myofibril and Pharmacology.

Between 2016 and 2021, his most popular works were:

  • Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling (75 citations)
  • Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo (45 citations)
  • Epigallocatechin gallate sensitizes cisplatin-resistant oral cancer CAR cell apoptosis and autophagy through stimulating AKT/STAT3 pathway and suppressing multidrug resistance 1 signaling (44 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Apoptosis

The scientist’s investigation covers issues in Cancer research, Apoptosis, Cell biology, Protein kinase B and Cancer cell. His research in Cancer research focuses on subjects like p38 mitogen-activated protein kinases, which are connected to Human cancer, Lupeol, Osteosarcoma and Pi3k akt signaling. His studies in ATG12, Viability assay, Cell cycle and DNA fragmentation are all subfields of Apoptosis research.

Jai Sing Yang combines subjects such as DAPI and Molecular biology with his study of Viability assay. The concepts of his Cell biology study are interwoven with issues in Angiogenesis and Cerebroside. His studies deal with areas such as Cell, AMPK and Programmed cell death as well as Cancer cell.

Best Publications

  • Quercetin-mediated Cell Cycle Arrest and Apoptosis Involving Activation of a Caspase Cascade through the Mitochondrial Pathway in Human Breast Cancer MCF-7 Cells

    Chu Chung Chou;Jai Sing Yang;Hsu Feng Lu;Siu Wan Ip

  • Quercetin-induced apoptosis acts through mitochondrial- and caspase-3-dependent pathways in human breast cancer MDA-MB-231 cells.

    Su Yu Chien;Yao Chung Wu;Jing Gung Chung;Jai Sing Yang

  • Curcumin Induces Apoptosis in Human Non-small Cell Lung Cancer NCI-H460 Cells through ER Stress and Caspase Cascade- and Mitochondria-dependent Pathways

    Shin Hwar Wu;Liang Wen Hang;Jai Sing Yang;Hung Yi Chen

  • Curcumin inhibits the migration and invasion of human A549 lung cancer cells through the inhibition of matrix metalloproteinase-2 and -9 and Vascular Endothelial Growth Factor (VEGF)

    Song Shei Lin;Kuang Chi Lai;Shu Chun Hsu;Jai Sing Yang

  • Gallic acid induces apoptosis via caspase-3 and mitochondrion-dependent pathways in vitro and suppresses lung xenograft tumor growth in vivo.

    Bin-Chuan Ji;Wu-Huei Hsu;Jai-Sing Yang;Te-Chun Hsia

  • Curcumin-induced Apoptosis of Human Colon Cancer Colo 205 Cells through the Production of ROS, Ca2+ and the Activation of Caspase-3

    Chin Cheng Su;Jaung Geng Lin;Te Mao Li;Jing Gung Chung

  • Danthron, an Anthraquinone Derivative, Induces DNA Damage and Caspase Cascades-Mediated Apoptosis in SNU-1 Human Gastric Cancer Cells through Mitochondrial Permeability Transition Pores and Bax-Triggered Pathways

    Jo Hua Chiang;Jai Sing Yang;Chia Yu Ma;Mei Due Yang

  • Chrysophanol induces necrosis through the production of ROS and alteration of ATP levels in J5 human liver cancer cells

    Chi Cheng Lu;Jai Sing Yang;An Cheng Huang;Te Chun Hsia

  • DNA damage and endoplasmic reticulum stress mediated curcumin-induced cell cycle arrest and apoptosis in human lung carcinoma A-549 cells through the activation caspases cascade- and mitochondrial-dependent pathway

    Song Shei Lin;Hsuan Pang Huang;Jai Sing Yang;Jeng Yuan Wu

  • Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells.

    Wen Wen Huang;Yu Jen Chiu;Ming Jen Fan;Hsu Feng Lu

  • Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway

    Kuang-Chi Lai;An-Cheng Huang;Shu-Chun Hsu;Chao-Lin Kuo

  • Berberine induces cell cycle arrest and apoptosis in human gastric carcinoma SNU-5 cell line.

    Jing Pin Lin;Jai Sing Yang;Jau Hong Lee;Wen Tsong Hsieh

  • Berberine suppresses in vitro migration and invasion of human SCC-4 tongue squamous cancer cells through the inhibitions of FAK, IKK, NF-κB, u-PA and MMP-2 and -9

    Yung Tsuan Ho;Jai Sing Yang;Tsai Chung Li;Jen Jyh Lin

  • Resveratrol-induced autophagy and apoptosis in cisplatin-resistant human oral cancer CAR cells: A key role of AMPK and Akt/mTOR signaling

    Chao Hsiang Chang;Chao Ying Lee;Chi Cheng Lu;Fuu Jen Tsai

  • Berberine induced apoptosis via promoting the expression of caspase-8, -9 and -3, apoptosis-inducing factor and endonuclease G in SCC-4 human tongue squamous carcinoma cancer cells

    Yung Tsuan Ho;Chi Cheng Lu;Jai Sing Yang;Jo Hua Chiang

  • Gallic acid induces apoptosis in A375.S2 human melanoma cells through caspase-dependent and -independent pathways

    Chyi Lo;Tung-Yuan Lai;Jen-Hung Yang;Jai-Sing Yang

  • Rutin inhibits human leukemia tumor growth in a murine xenograft model in vivo.

    Jing Pin Lin;Jai Sing Yang;Jen Jyh Lin;Kuang Chi Lai

  • The Role of Mitochondria in Bee Venom-induced Apoptosis in Human Breast Cancer MCF7 Cells

    Siu Wan Ip;Shin Shin Liao;Shuw Yuan Lin;Jing Pin Lin

  • Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-κB and matrix metalloproteinase-2/-9 signaling pathways

    Wan Wen Lai;Shu Chun Hsu;Fu Shih Chueh;Ya Yin Chen

  • Benzyl isothiocyanate (BITC) and phenethyl isothiocyanate (PEITC)‐mediated generation of reactive oxygen species causes cell cycle arrest and induces apoptosis via activation of caspase‐3, mitochondria dysfunction and nitric oxide (NO) in human osteogenic sarcoma U‐2 OS cells

    Chang Lin Wu;An Cheng Huang;Jai Sing Yang;Ching Lung Liao

Frequent Co-Authors

Jing Gung Chung
Jing Gung Chung China Medical University
Sheng-Chu Kuo
Sheng-Chu Kuo China Medical University
Fuu Jen Tsai
Fuu Jen Tsai China Medical University
Tian Shung Wu
Tian Shung Wu National Cheng Kung University
W. Gibson Wood
W. Gibson Wood University of Minnesota
Kuo Hsiung Lee
Kuo Hsiung Lee University of Minnesota
Chang Hai Tsai
Chang Hai Tsai Asian University
Chih-Hsin Tang
Chih-Hsin Tang China Medical University
Che-Ming Teng
Che-Ming Teng National Taiwan University
Yang Chang Wu
Yang Chang Wu China Medical University

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