His primary areas of investigation include Cell biology, ADAM10, Disintegrin, Ectodomain and Chemokine. His Cell biology research includes themes of Tumor necrosis factor alpha, Inflammation, Internal medicine, Endocrinology and Cadherin. His work deals with themes such as Proteases, Sheddase and Cell growth, which intersect with ADAM10.
He combines subjects such as Molecular biology, CXCL16 and Cell adhesion with his study of Disintegrin. His biological study spans a wide range of topics, including Ionomycin, Cleavage, ADAM17 Protein and Matrix metalloproteinase. His Chemokine research integrates issues from Progenitor cell, Homing and Monocyte.
His primary areas of study are Cell biology, ADAM10, Chemokine, Immunology and Internal medicine. His research in Cell biology intersects with topics in Cell, Cell migration, Cell adhesion, Biochemistry and Molecular biology. The ADAM10 study combines topics in areas such as Proteases, Cancer research and Ectodomain.
The study incorporates disciplines such as Chemotaxis and Transmembrane protein in addition to Chemokine. His studies deal with areas such as Receptor and In vivo as well as Immunology. His Internal medicine study which covers Endocrinology that intersects with Electrical conduction system of the heart.
His main research concerns Cell biology, ADAM10, Metalloproteinase, Cancer research and Disintegrin. Andreas Ludwig works in the field of Cell biology, namely Cell adhesion molecule. The various areas that Andreas Ludwig examines in his ADAM10 study include Proteases and Membrane protein.
In his study, Hepatic stellate cell and CX3CL1 is strongly linked to Proinflammatory cytokine, which falls under the umbrella field of Cancer research. His research integrates issues of Cell adhesion, Cytokine and Cell growth in his study of Molecular biology. His Lung research includes elements of Inflammation and Chemokine.
His scientific interests lie mostly in Cell biology, Matrix metalloproteinase, ADAM10, Biochemistry and Proteases. His Cell biology research focuses on Cell adhesion molecule in particular. In his research, Amphiregulin and Molecular biology is intimately related to Cell, which falls under the overarching field of Matrix metalloproteinase.
He has researched ADAM10 in several fields, including Synapse, Axon, Membrane protein and Neural cell adhesion molecule. His work in the fields of Biochemistry, such as In vitro, Glycosylation, Binding site and Active site, intersects with other areas such as Drug development. His study explores the link between Proteases and topics such as Protease that cross with problems in Serine and Proteolysis.
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ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Thorsten Maretzky;Karina Reiss;Andreas Ludwig;Julian Buchholz.
Proceedings of the National Academy of Sciences of the United States of America (2005)
ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling
Karina Reiss;Thorsten Maretzky;Andreas Ludwig;Thomas Tousseyn.
The EMBO Journal (2005)
The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart
Juliane Stieber;Stefan Herrmann;Susanne Feil;Jana Löster.
Proceedings of the National Academy of Sciences of the United States of America (2003)
The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.
Soeren Abel;Christian Hundhausen;Rolf Mentlein;Alexander Schulte.
Journal of Immunology (2004)
Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)
Vance Matthews;Björn Schuster;Stefan Schütze;Ingo Bussmeyer.
Journal of Biological Chemistry (2003)
Tumor-associated MICA is shed by ADAM proteases.
Inja Waldhauer;Dennis Goehlsdorf;Friederike Gieseke;Toni Weinschenk.
Cancer Research (2008)
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.
Andreas Ludwig;Christian Hundhausen;Millard Lambert;Neil Broadway.
Combinatorial Chemistry & High Throughput Screening (2005)
Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3
Martin Biel;Mathias Seeliger;Alexander Pfeifer;Konrad Kohler.
Proceedings of the National Academy of Sciences of the United States of America (1999)
A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44
Alexander Stoeck;Sascha Keller;Svenja Riedle;Michael P. Sanderson.
Biochemical Journal (2006)
ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin
Beate Schulz;Jessica Pruessmeyer;Thorsten Maretzky;Andreas Ludwig.
Circulation Research (2008)
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