World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
24813
World Ranking
2863
National Ranking
211

Overview

Andreas Ludwig is affiliated with RWTH Aachen University in Germany. Their research primarily focuses on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with specific attention to Molecular Biology, Oncology, Immunology, Cancer Research, and Pulmonary and Respiratory Medicine.

The scientist's work encompasses several key topics including HER2/EGFR in Cancer Research, Peptidase Inhibition and Analysis, Cell Adhesion Molecules Research, Protease and Inhibitor Mechanisms, 3D Printing in Biomedical Research, Electrospun Nanofibers in Biomedical Applications, and Angiogenesis and VEGF in Cancer.

Andreas Ludwig has published noteworthy papers in prominent journals. Some recent publications include:

  • "Key metalloproteinase-mediated pathways in the kidney," 2021, Nature Reviews Nephrology
  • "The metalloproteinase ADAM10 requires its activity to sustain surface expression," 2020, Cellular and Molecular Life Sciences
  • "Expression levels of the metalloproteinase ADAM8 critically regulate proliferation, migration and malignant signalling events in hepatoma cells," 2020, Journal of Cellular and Molecular Medicine
  • "The collectrin-like part of the SARS-CoV-1 and -2 receptor ACE2 is shed by the metalloproteinases ADAM10 and ADAM17," 2022, The FASEB Journal
  • "Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics," 2021, Advanced Biology

Their frequent coauthors include Aaron Babendreyer, Stefan Düsterhöft, Justyna Wozniak, Anke Seifert, and Daniela Yildiz. These collaborations appear across multiple publications, indicating sustained research partnerships.

Andreas Ludwig's research has been published repeatedly in venues such as Cellular and Molecular Life Sciences, Scientific Reports, RWTH Publications (RWTH Aachen), The FASEB Journal, and Frontiers in Cardiovascular Medicine.

Best Publications

  • A family of hyperpolarization-activated mammalian cation channels

    Andreas Ludwig;Xiangang Zong;Michael Jeglitsch;Franz Hofmann

  • ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

    Thorsten Maretzky;Karina Reiss;Andreas Ludwig;Julian Buchholz

  • The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

    Christian Hundhausen;Dominika Misztela;Theo A. Berkhout;Neil Broadway

  • Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2

    Andreas Ludwig;Thomas Budde;Juliane Stieber;Sven Moosmang

  • ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling

    Karina Reiss;Thorsten Maretzky;Andreas Ludwig;Thomas Tousseyn

  • The hyperpolarization-activated channel HCN4 is required for the generation of pacemaker action potentials in the embryonic heart

    Juliane Stieber;Stefan Herrmann;Susanne Feil;Jana Löster

  • Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues

    Sven Moosmang;Juliane Stieber;Xiangang Zong;Martin Biel

  • The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

    Soeren Abel;Christian Hundhausen;Rolf Mentlein;Alexander Schulte

  • Tumor-associated MICA is shed by ADAM proteases.

    Inja Waldhauer;Dennis Goehlsdorf;Friederike Gieseke;Toni Weinschenk

  • Cellular Cholesterol Depletion Triggers Shedding of the Human Interleukin-6 Receptor by ADAM10 and ADAM17 (TACE)

    Vance Matthews;Björn Schuster;Stefan Schütze;Ingo Bussmeyer

  • Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

    Andreas Ludwig;Christian Hundhausen;Millard H. Lambert;Neil Broadway

  • Regional Expression and Cellular Localization of the α1 and β Subunit of High Voltage-Activated Calcium Channels in Rat Brain

    Andreas Ludwig;Veit Flockerzi;Franz Hofmann

  • A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44

    Alexander Stoeck;Sascha Keller;Svenja Riedle;Michael P. Sanderson

  • ADAM10 Regulates Endothelial Permeability and T-Cell Transmigration by Proteolysis of Vascular Endothelial Cadherin

    Beate Schulz;Jessica Pruessmeyer;Thorsten Maretzky;Andreas Ludwig

  • In vivo structure/function and expression analysis of the CX3C chemokine fractalkine

    Ki-Wook Kim;Alexandra Vallon-Eberhard;Ehud Zigmond;Ehud Zigmond;Julia Farache

  • The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer.

    Jessica Pruessmeyer;Andreas Ludwig

  • HCN4 provides a 'depolarization reserve' and is not required for heart rate acceleration in mice.

    Stefan Herrmann;Juliane Stieber;Georg Stöckl;Franz Hofmann

  • Importance of CXC Chemokine Receptor 2 in the Homing of Human Peripheral Blood Endothelial Progenitor Cells to Sites of Arterial Injury

    Mihail Hristov;Alma Zernecke;Kiril Bidzhekov;Elisa A. Liehn

  • L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth

    Thorsten Maretzky;Marc Schulte;Andreas Ludwig;Stefan Rose-John

  • ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23

    Gisela Weskamp;Jill W Ford;Jamie Sturgill;Steve Martin

Frequent Co-Authors

Paul Saftig
Paul Saftig Kiel University
Christian Weber
Christian Weber Ludwig-Maximilians-Universität München
Franz Hofmann
Franz Hofmann Technical University of Munich
Stefan Rose-John
Stefan Rose-John Kiel University
Dieter Hartmann
Dieter Hartmann University of Bonn
Hans-Dieter Flad
Hans-Dieter Flad Research Center Borstel - Leibniz-Center for Medicine and Biosciences
Rolf Mentlein
Rolf Mentlein Kiel University
Peter Altevogt
Peter Altevogt German Cancer Research Center
Martin Biel
Martin Biel Ludwig-Maximilians-Universität München
Josef Pfeilschifter
Josef Pfeilschifter Goethe University Frankfurt

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