D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 86 Citations 25,474 175 World Ranking 1333 National Ranking 792

Research.com Recognitions

Awards & Achievements

Member of the Association of American Physicians

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Cytokine

Carl P. Blobel mostly deals with Cell biology, Disintegrin, Biochemistry, Sheddase and Metalloproteinase. His work deals with themes such as Cell adhesion, Neural cell adhesion molecule, ADAM17 Protein and ADAM10, which intersect with Cell biology. His Sheddase research incorporates themes from Epidermal growth factor, Epidermal growth factor receptor and Cancer research.

Carl P. Blobel has researched Epidermal growth factor in several fields, including Molecular biology and Growth factor. His biological study spans a wide range of topics, including Tumor necrosis factor alpha, Cell culture and Ectodomain. His study explores the link between Ectodomain and topics such as ADAM9 that cross with problems in ADAM Proteins and Myoblast fusion.

His most cited work include:

  • ADAMs: key components in EGFR signalling and development (902 citations)
  • Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands (800 citations)
  • A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion. (614 citations)

What are the main themes of his work throughout his whole career to date?

His primary scientific interests are in Cell biology, Metalloproteinase, Disintegrin, Ectodomain and ADAM10. Carl P. Blobel interconnects Molecular biology, ADAM17 Protein and Sheddase in the investigation of issues within Cell biology. His Sheddase research focuses on subjects like Epidermal growth factor receptor, which are linked to Transforming growth factor.

His Metalloproteinase study integrates concerns from other disciplines, such as Tumor necrosis factor alpha, Cancer research and Transmembrane domain. His work in the fields of Disintegrin, such as ADAM Proteins, intersects with other areas such as Secretory pathway. His study in Ectodomain is interdisciplinary in nature, drawing from both Betacellulin, Epidermal growth factor, Regulator and ADAM9.

He most often published in these fields:

  • Cell biology (72.95%)
  • Metalloproteinase (54.11%)
  • Disintegrin (41.55%)

What were the highlights of his more recent work (between 2015-2021)?

  • Cell biology (72.95%)
  • ADAM10 (33.33%)
  • Metalloproteinase (54.11%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cell biology, ADAM10, Metalloproteinase, Disintegrin and Notch signaling pathway. Specifically, his work in Cell biology is concerned with the study of Signal transduction. His research in ADAM10 intersects with topics in Proinflammatory cytokine, Cell signaling, Sheddase and Tumor necrosis factor alpha.

Carl P. Blobel has included themes like Cancer research and Epidermal growth factor receptor in his Metalloproteinase study. His studies in Disintegrin integrate themes in fields like Transmembrane domain, Epidermal growth factor, Ectodomain and Transmembrane protein. His work carried out in the field of Ectodomain brings together such families of science as Matrix metalloproteinase and ADAM9.

Between 2015 and 2021, his most popular works were:

  • iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling (41 citations)
  • A protective Langerhans cell–keratinocyte axis that is dysfunctional in photosensitivity (26 citations)
  • Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis. (22 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cytokine

Carl P. Blobel mainly investigates ADAM10, Cell biology, Notch signaling pathway, Angiogenesis and Endothelium. His ADAM10 research includes themes of Signal transduction and Immunology. The Angiogenesis study combines topics in areas such as Cell, Downregulation and upregulation, Homeostasis and Kidney development.

His Downregulation and upregulation study which covers Autoimmunity that intersects with Metalloproteinase. Carl P. Blobel integrates Metalloproteinase with Amyloid precursor protein secretase in his study. His Endothelium research is multidisciplinary, relying on both Regulator and Transcriptome.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

ADAMs: key components in EGFR signalling and development

Carl P. Blobel.
Nature Reviews Molecular Cell Biology (2005)

1435 Citations

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands

Umut Sahin;Gisela Weskamp;Kristine Kelly;Kristine Kelly;Hong-Ming Zhou.
Journal of Cell Biology (2004)

1074 Citations

A potential fusion peptide and an integrin ligand domain in a protein active in sperm-egg fusion.

Carl P. Blobel;Tyra G. Wolfsberg;Christoph W. Turck;Diana G. Myles.
Nature (1992)

885 Citations

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.

Johannes Schlöndorff;Carl P. Blobel.
Journal of Cell Science (1999)

773 Citations

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).

Kyle J. Garton;Peter J. Gough;Carl P. Blobel;Gillian Murphy.
Journal of Biological Chemistry (2001)

695 Citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

Lawrence Lum;Brian R. Wong;Régis Josien;J. David Becherer.
Journal of Biological Chemistry (1999)

596 Citations

Metalloprotease-Disintegrins: Links to Cell Adhesion and Cleavage of TNFα and Notch

Carl P Blobel.
Cell (1997)

528 Citations

Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans.

Peter Warwick Janes;Nayanendu Saha;William A Barton;Momchil V Kolev.
Cell (2005)

520 Citations

Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE).

J Schlöndorff;J D Becherer;C P Blobel.
Biochemical Journal (2000)

473 Citations

Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity

Monireh Roghani;J. David Becherer;Marcia L. Moss;Ruth E. Atherton.
Journal of Biological Chemistry (1999)

405 Citations

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