His primary areas of study are Matrix metalloproteinase, Biochemistry, Cell biology, Molecular biology and Proteases. His work carried out in the field of Matrix metalloproteinase brings together such families of science as Chemokine, Extracellular matrix, Cancer research and Cancer. As a part of the same scientific study, Christopher M. Overall usually deals with the Biochemistry, concentrating on Type I collagen and frequently concerns with Collagen receptor and Collagen, type I, alpha 1.
His Cell biology research is multidisciplinary, relying on both Integrin and Cell adhesion. His Molecular biology study combines topics in areas such as Cell culture, Gene expression, Concanavalin A, Fibronectin and Collagenase. His Proteases study incorporates themes from Cancer cell, Proteomics, Protease, Identification and Signal transduction.
Christopher M. Overall mainly investigates Biochemistry, Matrix metalloproteinase, Cell biology, Proteases and Protease. His Biochemistry research focuses on Proteome, Proteomics, Terminal amine isotopic labeling of substrates, Cleavage and Metalloproteinase. His Matrix metalloproteinase research incorporates elements of Inflammation, Chemokine, Immunology, Molecular biology and Extracellular matrix.
His study looks at the intersection of Molecular biology and topics like Fibronectin with Gelatinase. His study in Function extends to Proteases with its themes. Christopher M. Overall interconnects Peptide, Peptide sequence and Proteolysis in the investigation of issues within Protease.
His primary areas of investigation include Computational biology, Proteomics, Proteome, Human proteome project and Cell biology. His biological study spans a wide range of topics, including Protease and Genomics. His Proteome research is included under the broader classification of Biochemistry.
His research on Biochemistry focuses in particular on Shotgun. The various areas that Christopher M. Overall examines in his Cell biology study include Matrix metalloproteinase, Metalloproteinase, Zymogen activation and Proteolysis. He has included themes like Cell culture, Cell migration, Proteases, Cell membrane and Peptide in his Terminal amine isotopic labeling of substrates study.
Christopher M. Overall focuses on Computational biology, Human proteome project, Proteomics, Cell biology and Inflammation. His studies examine the connections between Human proteome project and genetics, as well as such issues in Proteome, with regards to Human proteins and Data-independent acquisition. His work deals with themes such as Eukaryotic translation, Protein domain, Untranslated region and Methionine, which intersect with Proteomics.
His studies in Cell biology integrate themes in fields like Cleavage, Proteases, Protease, Proteolysis and Terminal amine isotopic labeling of substrates. His Inflammation study combines topics from a wide range of disciplines, such as Autoimmune disease, Synovitis, Matrix metalloproteinase and MHC class II. His work on Ecm degradation as part of general Matrix metalloproteinase study is frequently linked to Context, bridging the gap between disciplines.
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Strategies for MMP inhibition in cancer: innovations for the post-trial era
Christopher Mark Overall;Carlos López-Otín.
Nature Reviews Cancer (2002)
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
Christopher M. Overall;Oded Kleifeld.
Nature Reviews Cancer (2006)
Human and mouse proteases: a comparative genomic approach
Xose S. Puente;Luis M. Sánchez;Christopher M. Overall;Carlos López-Otín.
Nature Reviews Genetics (2003)
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion
Katarina Wolf;Yi I. Wu;Yi I. Wu;Yueying Liu;Jörg Geiger.
Nature Cell Biology (2007)
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.
G. Angus McQuibban;Jiang-Hong Gong;Eric M. Tam;Christopher A. G. McCulloch.
Protease degradomics: a new challenge for proteomics.
Carlos López-Otín;Christopher M. Overall.
Nature Reviews Molecular Cell Biology (2002)
Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-β
C M Overall;J L Wrana;J Sodek.
Journal of Biological Chemistry (1989)
Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1
G. Angus McQuibban;Georgina S. Butler;Jiang-Hong Gong;Linda Bendall.
Journal of Biological Chemistry (2001)
Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo
G. Angus McQuibban;Jiang-Hong Gong;Julie P. Wong;John L. Wallace.
Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites.
Christopher M Overall.
Molecular Biotechnology (2002)
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