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Christopher M. Overall

Christopher M. Overall

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
109
Citations
42112
World Ranking
1009
National Ranking
25

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Christopher M. Overall is affiliated with the University of British Columbia in Canada. Their research focuses primarily on the fields of Biochemistry, Genetics and Molecular Biology, and Medicine.

Within these broad fields, their subfields of specialization include Molecular Biology, Spectroscopy, Oncology, Immunology, and Infectious Diseases. Their work covers a range of topics, including Advanced Proteomics Techniques and Applications, Machine Learning in Bioinformatics, Peptidase Inhibition and Analysis, RNA and protein synthesis mechanisms, SARS-CoV-2 and COVID-19 Research, Protease and Inhibitor Mechanisms, and interferon and immune responses.

Christopher M. Overall has published in several scientific journals, with frequent contributions to the Journal of Proteome Research, bioRxiv (Cold Spring Harbor Laboratory), IUPHAR/BPS Guide to Pharmacology CITE, Cell Reports, and Journal of Virology.

The scientist's recent papers include:

  • A high-stringency blueprint of the human proteome (2020), published in Nature Communications
  • Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome (2021), published in Cell Reports
  • Classification and Nomenclature of Metacaspases and Paracaspases: No More Confusion with Caspases (2020), published in Molecular Cell
  • Experimental autoimmune encephalomyelitis is associated with changes of the microbiota composition in the gastrointestinal tract (2020), published in Scientific Reports
  • DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics (2020), published in eLife

Frequent collaborators in their research include:

  • Nestor Solis
  • Gilbert S. Omenn
  • Cecilia Lindskog
  • Robert L. Moritz
  • Ruedi Aebersold

Best Publications

  • Strategies for MMP inhibition in cancer: innovations for the post-trial era

    Christopher Mark Overall;Carlos López-Otín

  • Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy

    Christopher M. Overall;Oded Kleifeld

  • Human and mouse proteases: a comparative genomic approach

    Xose S. Puente;Luis M. Sánchez;Christopher M. Overall;Carlos López-Otín

  • Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

    Katarina Wolf;Yi I. Wu;Yi I. Wu;Yueying Liu;Jörg Geiger

  • Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.

    G. Angus McQuibban;Jiang-Hong Gong;Eric M. Tam;Christopher A. G. McCulloch

  • Protease degradomics: a new challenge for proteomics.

    Carlos López-Otín;Christopher M. Overall

  • Independent regulation of collagenase, 72-kDa progelatinase, and metalloendoproteinase inhibitor expression in human fibroblasts by transforming growth factor-beta.

    C M Overall;J L Wrana;J Sodek

  • Targeting Tumor Hypoxia: Suppression of Breast Tumor Growth and Metastasis by Novel Carbonic Anhydrase IX Inhibitors

    Yuanmei Lou;Paul C McDonald;Arusha Oloumi;Stephen K. Chia

  • Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1

    G. Angus McQuibban;Georgina S. Butler;Jiang Hong Gong;Linda Bendall

  • Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo

    G. Angus McQuibban;Jiang-Hong Gong;Julie P. Wong;John L. Wallace

  • Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites.

    Christopher M Overall

  • Matrix metalloproteinases: what do they not do? New substrates and biological roles identified by murine models and proteomics.

    David Rodríguez;Charlotte J. Morrison;Christopher M. Overall

  • Transcriptional and post-transcriptional regulation of 72-kDa gelatinase/type IV collagenase by transforming growth factor-beta 1 in human fibroblasts. Comparisons with collagenase and tissue inhibitor of matrix metalloproteinase gene expression.

    C M Overall;J L Wrana;J Sodek

  • Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

    Oded Kleifeld;Alain Doucet;Ulrich auf dem Keller;Anna Prudova

  • Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells.

    Rama Khokha;Paul Waterhouse;Simcha Yagel;Peeyush K. Lala

  • Loss of collagenase-2 confers increased skin tumor susceptibility to male mice

    Milagros Balbín;Antonio Fueyo;Angus M Tester;Alberto M Pendás

  • Microbiota and crevicular fluid collagenase activity in the osseointegrated dental implant sulcus: a comparison of sites in edentulous and partially edentulous patients.

    P. Apse;R. P. Ellen;C. M. Overall;G. A. Zarb

  • Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.

    Oliver Schilling;Christopher M Overall

  • Towards third generation matrix metalloproteinase inhibitors for cancer therapy.

    Christopher M Overall;Oded Kleifeld

  • In search of partners: linking extracellular proteases to substrates

    Christopher M. Overall;Carl P. Blobel

Frequent Co-Authors

Gilbert S. Omenn
Gilbert S. Omenn University of Michigan–Ann Arbor
Jaro Sodek
Jaro Sodek University of Toronto
Eric W. Deutsch
Eric W. Deutsch University of Washington
Oliver Schilling
Oliver Schilling University of Freiburg
Young Ki Paik
Young Ki Paik Yonsei University
Christopher A. McCulloch
Christopher A. McCulloch University of Toronto
Jayachandran N. Kizhakkedathu
Jayachandran N. Kizhakkedathu University of British Columbia
Mark S. Baker
Mark S. Baker Macquarie University
Jennifer E. Van Eyk
Jennifer E. Van Eyk Cedars-Sinai Medical Center
Carlos López-Otín
Carlos López-Otín University of Oviedo

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