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Jayachandran N. Kizhakkedathu

Jayachandran N. Kizhakkedathu

D-Index & Metrics

Materials Science

D-Index
59
Citations
9434
World Ranking
7527
National Ranking
137

Chemistry

D-Index
62
Citations
12122
World Ranking
8944
National Ranking
230

Overview

Jayachandran N. Kizhakkedathu is affiliated with the University of British Columbia in Canada. Their primary research activity centers on the field of medicine, with notable emphasis on hematology, molecular biology, surgery, genetics, and surfaces, coatings, and films. This multidisciplinary focus informs a body of work that intersects various biological and biomedical domains.

The scientist has contributed to multiple topics, which include:

  • Polymer Surface Interaction Studies
  • Platelet Disorders and Treatments
  • Renal Transplantation Outcomes and Treatments
  • RNA Interference and Gene Delivery
  • Blood Coagulation and Thrombosis Mechanisms
  • Coagulation, Bradykinin, Polyphosphates, and Angioedema
  • Dendrimers and Hyperbranched Polymers

The following are samples of their recent published work, illustrating the range and focus of their research:

  • Towards Robust Delivery of Antimicrobial Peptides to Combat Bacterial Resistance, 2020, Molecules
  • Transient blood thinning during extracorporeal blood purification via the inactivation of coagulation factors by hydrogel microspheres, 2021, Nature Biomedical Engineering
  • Understanding the Interaction of Polyelectrolyte Architectures with Proteins and Biosystems, 2020, Angewandte Chemie International Edition
  • Surface modification approaches for prevention of implant associated infections, 2020, Colloids and Surfaces B Biointerfaces
  • Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome, 2021, Cell Reports

Frequent collaborators in their research endeavors include:

  • Srinivas Abbina
  • Kai Yu
  • Sreeparna Vappala
  • Dirk Lange
  • Stephen G. Withers

Jayachandran N. Kizhakkedathu has published repeatedly in several prominent venues, which are known for their contributions to biological and medical sciences research. These include:

  • Nature Communications
  • Blood
  • ACS Applied Materials & Interfaces
  • Research and Practice in Thrombosis and Haemostasis
  • Biomacromolecules

Best Publications

  • Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products

    Oded Kleifeld;Alain Doucet;Ulrich auf dem Keller;Anna Prudova

  • The biocompatibility and biofilm resistance of implant coatings based on hydrophilic polymer brushes conjugated with antimicrobial peptides

    Guangzheng Gao;Dirk Lange;Kai Hilpert;Jason Kindrachuk

  • Multilayered coating on titanium for controlled release of antimicrobial peptides for the prevention of implant-associated infections

    Mehdi Kazemzadeh-Narbat;Benjamin F.L. Lai;Chuanfan Ding;Jayachandran N. Kizhakkedathu

  • Identifying and quantifying proteolytic events and the natural N terminome by terminal amine isotopic labeling of substrates

    Oded Kleifeld;Oded Kleifeld;Alain Doucet;Anna Prudova;Ulrich auf dem Keller;Ulrich auf dem Keller

  • Blood compatibility of novel water soluble hyperbranched polyglycerol-based multivalent cationic polymers and their interaction with DNA.

    Rajesh Kumar Kainthan;Muthiah Gnanamani;Munia Ganguli;Tanay Ghosh

  • Synthesis of well-defined environmentally responsive polymer brushes by aqueous ATRP

    Jayachandran N. Kizhakkedathu;† and Raymond Norris-Jones;Donald E. Brooks

  • Anti-adhesive antimicrobial peptide coating prevents catheter associated infection in a mouse urinary infection model

    Kai Yu;Joey C.Y. Lo;Mei Yan;Xiaoqiang Yang

  • Attaching folic acid on gold nanoparticles using noncovalent interaction via different polyethylene glycol backbones and targeting of cancer cells

    Resham Bhattacharya;Chitta Ranjan Patra;Alexis Earl;Shanfeng Wang

  • Self-assembled monothiol-terminated hyperbranched polyglycerols on a gold surface: a comparative study on the structure, morphology, and protein adsorption characteristics with linear poly(ethylene glycol)s.

    † Po-Ying J.Yeh;Rajesh K. Kainthan;Yuquan Zou;Mu Chiao, ,† and

  • Polyvalent choline phosphate as a universal biomembrane adhesive

    Xifei Yu;Zonghua Liu;Johan Janzen;Irina Chafeeva

  • Antibacterial surfaces based on polymer brushes: investigation on the influence of brush properties on antimicrobial peptide immobilization and antimicrobial activity.

    Guangzheng Gao;Kai Yu;Jason Kindrachuk;Donald E. Brooks

  • Polymer brush-based approaches for the development of infection-resistant surfaces

    Narges Hadjesfandiari;Kai Yu;Yan Mei;Jayachandran N. Kizhakkedathu

  • Hyperbranched polyglycerols: recent advances in synthesis, biocompatibility and biomedical applications.

    Srinivas Abbina;Sreeparna Vappala;Prashant Kumar;Erika M. J. Siren

  • Influence of architecture of high molecular weight linear and branched polyglycerols on their biocompatibility and biodistribution.

    Muhammad Imran ul-haq;Benjamin F.L. Lai;Rafi Chapanian;Jayachandran N. Kizhakkedathu

  • Reversible hemostatic properties of sulfabetaine/quaternary ammonium modified hyperbranched polyglycerol.

    Jiying Wen;Marie Weinhart;Benjamin Lai;Jayachandran Kizhakkedathu

  • Antibacterial Properties of hLf1–11 Peptide onto Titanium Surfaces: A Comparison Study Between Silanization and Surface Initiated Polymerization

    Maria Godoy-Gallardo;Carlos Mas-Moruno;Kai Yu;José M. Manero

  • Effect of Extreme Wettability on Platelet Adhesion on Metallic Implants: From Superhydrophilicity to Superhydrophobicity

    Sona Moradi;Narges Hadjesfandiari;Salma Fallah Toosi;Jayachandran N. Kizhakkedathu

  • Synthesis of poly(N, N-dimethylacrylamide) brushes from charged polymeric surfaces by aqueous ATRP: Effect of surface initiator concentration

    Jayachandran N. Kizhakkedathu;Donald E. Brooks

  • Hydrophobically derivatized hyperbranched polyglycerol as a human serum albumin substitute.

    Rajesh K. Kainthan;Johan Janzen;Jayachandran N. Kizhakkedathu;Dana V. Devine;Dana V. Devine

  • Branched multifunctional polyether polyketals: variation of ketal group structure enables unprecedented control over polymer degradation in solution and within cells.

    Rajesh A. Shenoi;Jayaprakash K. Narayanannair;Jasmine L. Hamilton;Benjamin F. L. Lai

Frequent Co-Authors

Donald E. Brooks
Donald E. Brooks University of British Columbia
Christopher M. Overall
Christopher M. Overall University of British Columbia
Oliver Schilling
Oliver Schilling University of Freiburg
Robert E. W. Hancock
Robert E. W. Hancock University of British Columbia
Souvik Maiti
Souvik Maiti Institute of Genomics and Integrative Biology
Stephen G. Withers
Stephen G. Withers University of British Columbia
Rainer Haag
Rainer Haag Freie Universität Berlin
James H. Morrissey
James H. Morrissey University of Michigan–Ann Arbor
Ravin Narain
Ravin Narain University of Alberta
Helen M. Burt
Helen M. Burt University of British Columbia

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