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Chemistry
Canada
2025

D-Index & Metrics

Chemistry

D-Index
108
Citations
42871
World Ranking
871
National Ranking
19

Research.com Recognitions

  • 2025 - Research.com Chemistry in Canada Leader Award
  • 2022 - Research.com Chemistry in Canada Leader Award
  • 2016 - Chemical Institute of Canada Medal
  • 2012 - Centenary Prize, Royal Society of Chemistry (UK)
  • 2012 - Fellow of the Royal Society, United Kingdom
  • 2002 - Fellow of the Royal Society of Canada Academy of Science
  • 1993 - Rutherford Memorial Medal in Chemistry, Royal Society of Canada
  • 1988 - Corday–Morgan Prize, Royal Society of Chemistry (UK)

Overview

Stephen G. Withers is affiliated with the University of British Columbia in Canada. Their research spans fields including Biochemistry, Genetics and Molecular Biology, and Medicine, with notable focus on subfields such as Molecular Biology, Organic Chemistry, Physiology, Surgery, and Biotechnology.

The main topics covered in their work include:

  • Carbohydrate Chemistry and Synthesis
  • Glycosylation and Glycoproteins Research
  • Enzyme Production and Characterization
  • Lysosomal Storage Disorders Research
  • Renal Transplantation Outcomes and Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • Transplantation: Methods and Outcomes

Recent papers authored or co-authored by Withers include:

  • "Carbohydrate-active enzymes (CAZymes) in the gut microbiome", 2022, published in Nature Reviews Microbiology
  • "Ex vivo enzymatic treatment converts blood type A donor lungs into universal blood type lungs", 2022, published in Science Translational Medicine
  • "Bioelectrocatalysis with a palladium membrane reactor", 2023, published in Nature Communications
  • "Thioglycoligase derived from fungal GH3 β-xylosidase is a multi-glycoligase with broad acceptor tolerance", 2020, published in Nature Communications
  • "Four cellulose-active lytic polysaccharide monooxygenases from Cellulomonas species", 2021, published in Biotechnology for Biofuels

The scientist frequently publishes in venues such as:

  • ACS Central Science
  • ACS Chemical Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Angewandte Chemie International Edition

Frequent co-authors in their research include:

  • Seyed A. Nasseri
  • Peter Rahfeld
  • Jacob F. Wardman
  • Jayachandran N. Kizhakkedathu
  • Lyann Sim

Throughout their career, Withers has received several awards and honors, including:

  • Chemical Institute of Canada Medal, 2016
  • Centenary Prize, Royal Society of Chemistry (UK), 2012
  • Fellow of the Royal Society, United Kingdom, 2012
  • Fellow of the Royal Society of Canada, 2002 (Academy of Science)
  • Rutherford Memorial Medal in Chemistry, Royal Society of Canada, 1993
  • Corday-Morgan Prize, Royal Society of Chemistry (UK), 1988

Best Publications

  • Glycosyltransferases: structures, functions, and mechanisms.

    Lairson Ll;Henrissat B;Davies Gj;Withers Sg

  • Glycosidase Mechanisms: Anatomy of a Finely Tuned Catalyst

    David L. Zechel and;Stephen G. Withers

  • Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate

    David J. Vocadlo;Gideon J. Davies;Gideon J. Davies;Roger Laine;Stephen G. Withers

  • Glycosynthases: Mutant Glycosidases for Oligosaccharide Synthesis

    Lloyd F. Mackenzie;Qingping Wang;and R. Antony J. Warren;Stephen G. Withers

  • X-ray structures along the reaction pathway of cyclodextrin glycosyltransferase elucidate catalysis in the alpha-amylase family.

    Joost C.M. Uitdehaag;Renée Mosi;Kor H. Kalk;Bart A. van der Veen

  • The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes.

    Gary D. Brayer;Yaoguang Luo;Stephen G. Withers

  • Crystal structure of the retaining galactosyltransferase LgtC from Neisseria meningitidis in complex with donor and acceptor sugar analogs.

    Karina Persson;Hoa D. Ly;Manuela Dieckelmann;Warren W. Wakarchuk

  • Mechanism of Agrobacterium beta-glucosidase: kinetic studies.

    Julie B. Kempton;Stephen G. Withers

  • Crystallographic evidence for substrate-assisted catalysis in a bacterial beta-hexosaminidase.

    Brian L. Mark;David J. Vocadlo;Spencer Knapp;Barbara L. Triggs-Raine

  • Mutagenesis of glycosidases.

    Hoa D. Ly;Stephen G. Withers

  • The pKa of the general acid/base carboxyl group of a glycosidase cycles during catalysis: a 13C-NMR study of bacillus circulans xylanase.

    Lawrence P. McIntosh;Greg Hand;Philip E. Johnson;Manish D. Joshi

  • Snapshots along an enzymatic reaction coordinate: analysis of a retaining beta-glycoside hydrolase.

    G.J. Davies;L. Mackenzie;A. Varrot;M. Dauter

  • NAG-thiazoline, An N-Acetyl-β-hexosaminidase Inhibitor That Implicates Acetamido Participation

    Spencer Knapp;David Vocadlo;Zhinong Gao;Brian Kirk

  • Engineering of glycosidases and glycosyltransferases.

    Susan M Hancock;Mark D Vaughan;Stephen G Withers

  • Subsite mapping of the human pancreatic alpha-amylase active site through structural, kinetic, and mutagenesis techniques.

    Gary D. Brayer;Gary Sidhu;Robert Maurus;Edwin H. Rydberg

  • Stereoselective hydrolysis catalyzed by related beta-1,4-glucanases and beta-1,4-xylanases.

    J Gebler;N R Gilkes;M Claeyssens;D B Wilson

  • A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase

    Douglas H. Juers;Tom D. Heightman;Andrea Vasella;John D. McCarter

  • Unequivocal demonstration of the involvement of a glutamate residue as a nucleophile in the mechanism of a retaining glycosidase

    Stephen G. Withers;R. Antony J. Warren;Ian P. Street;Karen Rupitz

  • Hydrogen bonding and catalysis: a novel explanation for how a single amino acid substitution can change the pH optimum of a glycosidase

    Manish D. Joshi;Gary Sidhu;Isabelle Pot;Gary D. Brayer

  • Pharmacological Enhancement of β-Hexosaminidase Activity in Fibroblasts from Adult Tay-Sachs and Sandhoff Patients

    Michael B. Tropak;Stephen P. Reid;Marianne Guiral;Stephen G. Withers

  • Glycosidase mechanisms.

    Unknown

Frequent Co-Authors

Gary D. Brayer
Gary D. Brayer University of British Columbia
Warren W. Wakarchuk
Warren W. Wakarchuk University of Alberta
Gideon J. Davies
Gideon J. Davies University of York
Natalie C. J. Strynadka
Natalie C. J. Strynadka University of British Columbia
David J. Vocadlo
David J. Vocadlo Simon Fraser University
Lawrence P. McIntosh
Lawrence P. McIntosh University of British Columbia
Spencer J. Williams
Spencer J. Williams University of Melbourne
David R. Rose
David R. Rose University of Waterloo
R A Warren
R A Warren University of British Columbia
Don J. Mahuran
Don J. Mahuran University of Toronto

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