World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
74
Citations
18215
World Ranking
4747
National Ranking
1494

Biology and Biochemistry

D-Index
75
Citations
18803
World Ranking
5354
National Ranking
2538

Research.com Recognitions

  • 2015 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Xi Chen is a researcher affiliated with the University of California, Davis in the United States. Their primary fields of study include Medicine and Biochemistry, Genetics, and Molecular Biology, with a focus on Oncology, Molecular Biology, and Immunology as key subfields.

Their research emphasizes several main topics such as Cancer Immunotherapy and Biomarkers, Immune cells in cancer, Ferroptosis and cancer prognosis, CAR-T cell therapy research, PARP inhibition in cancer therapy, Cancer, Lipids, and Metabolism, and Lung Cancer Treatments and Mutations.

Xi Chen has contributed extensively to scientific literature. Some of their recent papers include:

  • M2-TAM subsets altered by lactic acid promote T-cell apoptosis through the PD-L1/PD-1 pathway (2020, Oncology Reports)
  • Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis (2020, Redox Biology)
  • Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics (2023, Cell Reports Medicine)
  • PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity (2020, Drug Discovery Today)
  • Canagliflozin primes antitumor immunity by triggering PD-L1 degradation in endocytic recycling (2023, Journal of Clinical Investigation)

Frequent co-authors collaborating with Xi Chen include Ling Ding, Qiaojun He, Gary A. Piazza, Donald J. Buchsbaum, and Adam B. Keeton.

They have published repeatedly in several venues, among which Frontiers in Pharmacology and Frontiers in Immunology stand out with seven publications each, followed by Cancer Research with five publications, and Acta Pharmaceutica Sinica B and Cancers each with three publications.

In terms of recognition, Xi Chen was awarded the title of Fellow of the American Association for the Advancement of Science (AAAS) in 2015.

Best Publications

  • Cu-Catalyzed Click Reaction in Carbohydrate Chemistry

    Vinod K. Tiwari;Bhuwan B. Mishra;Kunj B. Mishra;Nidhi Mishra

  • Advances in the Biology and Chemistry of Sialic Acids

    Xi Chen;Ajit Varki

  • Remodeling and glycoconjugation of peptides

    Frees Shawn De;David Zopf;Robert Bayer;Caryn Bowe

  • A multifunctional Pasteurella multocida sialyltransferase: a powerful tool for the synthesis of sialoside libraries.

    Hai Yu;Harshal Chokhawala;Rebekah Karpel;Hui Yu

  • Diversity in specificity, abundance, and composition of anti-Neu5Gc antibodies in normal humans: Potential implications for disease

    Vered Padler-Karavani;Hai Yu;Hongzhi Cao;Harshal Chokhawala

  • Sialic acid metabolism and sialyltransferases: natural functions and applications.

    Yanhong Li;Xi Chen

  • Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin.

    Emma Byres;Adrienne W Paton;James C Paton;Jonas C Lofling

  • Chemoenzymatic synthesis of CMP–sialic acid derivatives by a one-pot two-enzyme system: comparison of substrate flexibility of three microbial CMP–sialic acid synthetases

    Hai Yu;Hui Yu;Rebekah Karpel;Xi Chen

  • Human Milk Oligosaccharides (HMOS): Structure, Function, and Enzyme-Catalyzed Synthesis.

    Xi Chen

  • Glycopegylation methods and proteins/peptides produced by the methods

    Shawn DeFrees;David A. Zopf;Robert J. Bayer;David James Hakes

  • An infant-associated bacterial commensal utilizes breast milk sialyloligosaccharides.

    David A. Sela;Yanhong Li;Larry Lerno;Shuai Wu

  • Highly efficient chemoenzymatic synthesis of β1–4-linked galactosides with promiscuous bacterial β1–4-galactosyltransferases

    Kam Lau;Vireak Thon;Hai Yu;Li Ding

  • Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction

    Guo Yun Chen;Xi Chen;Samantha King;Karen A. Cavassani

  • One-pot three-enzyme chemoenzymatic approach to the synthesis of sialosides containing natural and non-natural functionalities

    Hai Yu;Harshal A. Chokhawala;Shengshu Huang;Xi Chen

  • Sensitive and Specific Detection of the Non-Human Sialic Acid N-Glycolylneuraminic Acid In Human Tissues and Biotherapeutic Products

    Sandra L. Diaz;Vered Padler-Karavani;Darius Ghaderi;Nancy Hurtado-Ziola

  • Novel mechanism for the generation of human xeno-autoantibodies against the nonhuman sialic acid N-glycolylneuraminic acid

    Rachel E. Taylor;Christopher J. Gregg;Vered Padler-Karavani;Darius Ghaderi

  • One-pot multienzyme (OPME) systems for chemoenzymatic synthesis of carbohydrates

    Hai Yu;Xi Chen

  • Extraction of titanium from different titania precursors by the FFC Cambridge process

    Unknown

  • Highly Efficient Chemoenzymatic Synthesis of α-Galactosyl Epitopes with a Recombinant α(1→3)-Galactosyltransferase

    Jianwen Fang;Jun Li;Xi Chen;Yingnan Zhang

  • Efficient Chemoenzymatic Synthesis of an N-glycan Isomer Library.

    Lei Li;Yunpeng Liu;Cheng Ma;Jingyao Qu

  • Pushing AI to wireless network edge: an overview on integrated sensing, communication, and computation towards 6G

    Unknown

  • Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.

    Guo Yun Chen;Nicholas K. Brown;Wei Wu;Zahra Khedri

  • Human Xeno-autoantibodies Against a Non-human Sialic acid Serve As Novel Serum Biomarkers and Immunotherapeutics in Cancer

    Vered Padler-Karavani;Nancy Hurtado-Ziola;Minya Pu;Hai Yu

Frequent Co-Authors

Hai Yu
Hai Yu University of California, Davis
Peng George Wang
Peng George Wang Georgia State University
Ajit Varki
Ajit Varki University of California, San Diego
J. Joshua Smith
J. Joshua Smith Memorial Sloan Kettering Cancer Center
Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center
Bing Zhang
Bing Zhang Baylor College of Medicine
Jennifer A. Pietenpol
Jennifer A. Pietenpol Vanderbilt University Medical Center
Maciej Wiznerowicz
Maciej Wiznerowicz Poznan University of Medical Sciences
Paul M. Sullam
Paul M. Sullam University of California, San Francisco
Nissi M. Varki
Nissi M. Varki University of California, San Diego

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