World's Best Scientists 2026 revealed!
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Biology and Biochemistry

D-Index
154
Citations
78756
World Ranking
158
National Ranking
111

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award

Overview

James C. Paulson is affiliated with the Scripps Research Institute in the United States. Their research primarily spans the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Within these domains, their work focuses on subfields including Molecular Biology, Immunology, Epidemiology, Infectious Diseases, and Virology.

The main topics covered in their research include Glycosylation and Glycoproteins Research, Immunotherapy and Immune Responses, Influenza Virus Research Studies, HIV Research and Treatment, Monoclonal and Polyclonal Antibodies Research, Immune Cell Function and Interaction, and Respiratory Viral Infections Research.

The scientist has published extensively, with frequent contributions to venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Science
  • Journal of Allergy and Clinical Immunology
  • Cell Host & Microbe

Recent selected papers include:

  • "Siglecs as Immune Cell Checkpoints in Disease" (2020) published in Annual Review of Immunology
  • "Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate" (2020) published in Science
  • "Probing the binding specificities of human Siglecs by cell-based glycan arrays" (2021) published in Proceedings of the National Academy of Sciences
  • "Adaptation of influenza viruses to human airway receptors" (2020) published in Journal of Biological Chemistry
  • "A single mutation in bovine influenza H5N1 hemagglutinin switches specificity to human receptors" (2024) published in Science

Frequent collaborators in their work include John R. Yates, Jolene K. Diedrich, Matthew S. Macauley, Sabyasachi Baboo, and Ryan McBride.

Best Publications

  • Siglecs and their roles in the immune system

    Paul R. Crocker;James C. Paulson;Ajit Varki

  • ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex

    M. L. Phillips;E. Nudelman;F. C. A. Gaeta;M. Perez

  • New world bats harbor diverse influenza A viruses.

    Suxiang Tong;Xueyong Zhu;Yan Li;Mang Shi

  • Structure of the influenza virus haemagglutinin complexed with its receptor, sialic acid

    W. Weis;J. H. Brown;S. Cusack;S. Cusack;J. C. Paulson

  • Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential

    Toshihiro Ito;J. Nelson S. S. Couceiro;Sørge Kelm;Linda G. Baum

  • Printed covalent glycan array for ligand profiling of diverse glycan binding proteins

    Ola Blixt;Steve Head;Tony Mondala;Christopher Scanlan

  • Glycosyltransferases. Structure, localization, and control of cell type-specific glycosylation.

    J. C. Paulson;Karen J. Colley

  • Structure and Receptor Specificity of the Hemagglutinin from an H5N1 Influenza Virus

    James Stevens;Ola Blixt;Terrence M. Tumpey;Jeffery K. Taubenberger

  • Receptor determinants of human and animal influenza virus isolates: differences in receptor specificity of the H3 hemagglutinin based on species of origin.

    Gary N. Rogers;James C. Paulson

  • Siglec-mediated regulation of immune cell function in disease

    Matthew S. Macauley;Paul R. Crocker;James C. Paulson

  • Receptor specificity in human, avian, and equine H2 and H3 influenza virus isolates.

    Robert J. Connor;Yoshihiro Kawaoka;Robert G. Webster;James C. Paulson

  • Symbol Nomenclature for Graphical Representations of Glycans.

    Ajit Varki;Richard D. Cummings;Markus Aebi;Nicole H. Packer

  • Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

    Robert M. Anthony;Falk Nimmerjahn;Falk Nimmerjahn;David J. Ashline;Vernon N. Reinhold

  • Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity

    G. N. Rogers;J. C. Paulson;R. S. Daniels;J. J. Skehel

  • A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

    Robert Pejchal;Katie J. Doores;Katie J. Doores;Laura M. Walker;Reza Khayat

  • Glycan Microarray Analysis of the Hemagglutinins from Modern and Pandemic Influenza Viruses Reveals Different Receptor Specificities

    James Stevens;Ola Blixt;Laurel Glaser;Jeffery K. Taubenberger

  • CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.

    M. J. Polley;M. L. Phillips;E. Wayner;E. Nudelman

  • Synthesis of sugar arrays in microtiter plate.

    Fabio Fazio;Marian C. Bryan;Ola Blixt;James C. Paulson

  • Glycoproteins: what are the sugar chains for?

    James C. Paulson

  • STRUCTURE, LOCALIZATION, AND CONTROL OF CELL TYPE-SPECIFIC GLYCOSYLATION

    James C. Paulson;Karen J. ColleyS

Frequent Co-Authors

Ian A. Wilson
Ian A. Wilson Scripps Research Institute
Ola Blixt
Ola Blixt University of Copenhagen
Dennis R. Burton
Dennis R. Burton Scripps Research Institute
Andrew B. Ward
Andrew B. Ward Scripps Research Institute
James Stevens
James Stevens National Center for Immunization and Respiratory Diseases
Xueyong Zhu
Xueyong Zhu Scripps Research Institute
John R. Yates
John R. Yates Scripps Research Institute
Robert W. Chesnut
Robert W. Chesnut Johns Hopkins University
Robert L. Hill
Robert L. Hill Duke University
Alma L. Burlingame
Alma L. Burlingame University of California, San Francisco

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