2023 - Research.com Microbiology in United Kingdom Leader Award
Paul R. Crocker spends much of his time researching Sialic Acid Binding Immunoglobulin-like Lectins, SIGLEC, Biochemistry, Molecular biology and Sialoadhesin. His work carried out in the field of Sialic Acid Binding Immunoglobulin-like Lectins brings together such families of science as Immune system, COS cells, Immunoglobulin superfamily and Cell biology. Paul R. Crocker interconnects Interleukin 12, Lymphokine-activated killer cell and Ganglioside GD3 in the investigation of issues within SIGLEC.
His study in Biochemistry is interdisciplinary in nature, drawing from both Selectin and Cell adhesion molecule. His studies in Molecular biology integrate themes in fields like Stromal cell, Janus kinase 3, Point mutation and Fragment crystallizable region. His Sialoadhesin study incorporates themes from Immunoglobulin domain, Glycoprotein, Cell adhesion, Cell surface receptor and Cell–cell interaction.
His main research concerns SIGLEC, Sialoadhesin, Biochemistry, Cell biology and Immunology. His SIGLEC research includes themes of Innate immune system, Stereochemistry, Sialic Acid Binding Immunoglobulin-like Lectins and Glycan. His Sialic Acid Binding Immunoglobulin-like Lectins research incorporates themes from COS cells and Immunoglobulin superfamily.
His biological study spans a wide range of topics, including Glycoprotein, Molecular biology, Sialic acid binding, Marginal zone and Spleen. The study incorporates disciplines such as CD22 and Cell adhesion molecule in addition to Biochemistry. As a part of the same scientific study, Paul R. Crocker usually deals with the Cell biology, concentrating on Macrophage and frequently concerns with Bone marrow.
His primary areas of study are SIGLEC, Cell biology, Immunology, Immune system and Macrophage. His SIGLEC study is related to the wider topic of Sialic acid. His research in Cell biology intersects with topics in Cell, Receptor, Sialic acid binding, T cell and Glycosylation.
In general Immunology, his work in Inflammation, Immunosurveillance, Lymphocyte and Microglia is often linked to Interleukin 23 linking many areas of study. His Immune system study combines topics from a wide range of disciplines, such as Cancer, Antigen, Glycan, Antibody and In vivo. While the research belongs to areas of Sialoadhesin, Paul R. Crocker spends his time largely on the problem of Spleen, intersecting his research to questions surrounding Marginal zone.
The scientist’s investigation covers issues in Immunology, Cell biology, SIGLEC, Inflammation and Microbiology. He usually deals with Immunology and limits it to topics linked to Parenchyma and Cell adhesion, C-C chemokine receptor type 6, Lymph, Immunity and Choroid plexus. The various areas that Paul R. Crocker examines in his Cell biology study include Cellular differentiation, Calcium flux, T cell, CD8 and Sialoadhesin.
His work in Sialoadhesin tackles topics such as Cytotoxic T cell which are related to areas like Dendritic cell. His SIGLEC research includes elements of Perivascular space, Tumor microenvironment, Cancer cell, Integrin alpha M and Microglia. His research integrates issues of Receptor, Signal transduction, Sialic Acid Binding Immunoglobulin-like Lectins and Glycan in his study of Immune system.
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Siglecs and their roles in the immune system
Paul R. Crocker;James C. Paulson;Ajit Varki.
Nature Reviews Immunology (2007)
A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration
Gitali Mukhopadhyay;Patrick Doherty;Frank S. Walsh;Paul R. Crocker.
Siglec-mediated regulation of immune cell function in disease
Matthew S. Macauley;Paul R. Crocker;James C. Paulson.
Nature Reviews Immunology (2014)
Siglecs, sialic acids and innate immunity
Paul R. Crocker;Ajit Varki.
Trends in Immunology (2001)
Sialoadhesin, myelin-associated glycoprotein and CD22 define a new family of sialic acid-dependent adhesion molecules of the immunoglobulin superfamily
Sørge Kelm;Andrea Pelz;Roland Schauer;Marie T. Filbin.
Current Biology (1994)
Siglecs: sialic-acid-binding immunoglobulin-like lectins in cell-cell interactions and signalling.
Paul R Crocker.
Current Opinion in Structural Biology (2002)
Carbohydrate recognition systems: functional triads in cell—cell interactions
Paul R Crocker;Ten Feizi.
Current Opinion in Structural Biology (1996)
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules
SD Freeman;S Kelm;EK Barber;PR Crocker.
Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations
Adele Hartnell;Jane Steel;Helen Turley;Margaret Jones.
Isolation of the gene for McLeod syndrome that encodes a novel membrane transport protein
Mengfatt Ho;Jamel Chelly;Nick Carter;Adrian Danek.
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