World's Best Scientists 2026 revealed!
Stephen M. Strittmatter

Stephen M. Strittmatter

D-Index & Metrics

Neuroscience

D-Index
115
Citations
48365
World Ranking
453
National Ranking
264

Biology and Biochemistry

D-Index
115
Citations
48467
World Ranking
788
National Ranking
493

Overview

Stephen M. Strittmatter is affiliated with Yale University in the United States. Their research spans multiple disciplines including Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology, with substantial focus on the subfields of Neurology, Physiology, Molecular Biology, Cellular and Molecular Neuroscience, and Immunology.

The scientific interests of Stephen M. Strittmatter cover a range of topics including:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and neurodegeneration mechanisms
  • Neuroscience and neuropharmacology research
  • Neurogenesis and neuroplasticity mechanisms
  • Nerve injury and regeneration
  • Amyotrophic lateral sclerosis research
  • Immune cells in cancer

Their recent notable publications include:

  • Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells (2021) published in Neuron
  • Molecular and cellular evolution of the primate dorsolateral prefrontal cortex (2022) published in Science
  • Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q (2022) published in Science Translational Medicine
  • Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy (2020) published in Acta Neuropathologica Communications
  • Optic nerve regeneration screen identifies multiple genes restricting adult neural repair (2021) published in Cell Reports

Frequent collaborators in their research include Hideyuki Takahashi, Takuya Toyonaga, Richard E. Carson, Zhengxin Cai, and Joshua Spurrier, with collaboration counts reaching up to a dozen papers.

Stephen M. Strittmatter has contributed extensively to various publication venues, with the largest number of outputs appearing in bioRxiv (Cold Spring Harbor Laboratory). Other frequently targeted journals and conference proceedings include Alzheimer's & Dementia, Nature Communications, proceedings of the International Society for Magnetic Resonance in Medicine scientific meeting, and Alzheimer's Research & Therapy.

The scope of their work incorporates both fundamental and translational aspects of neuroscience and medicine, aiming to elucidate mechanisms underlying neurodegenerative diseases and neural repair. This is reflected in their multidisciplinary approach of combining molecular, cellular, and systems-level studies.

Best Publications

  • Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

    Juha Laurén;David A. Gimbel;Haakon B. Nygaard;John W. Gilbert

  • Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

    Jonathan A. Javitch;Robert J. D'Amato;Stephen M. Strittmatter;Solomon H. Snyder

  • Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein

    Tadzia GrandPré;Fumio Nakamura;Timothy Vartanian;Stephen M. Strittmatter

  • Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration

    Alyson E. Fournier;Tadzia GrandPre;Stephen M. Strittmatter

  • Nogo-66 receptor antagonist peptide promotes axonal regeneration.

    Tadzia GrandPré;Shuxin Li;Stephen M. Strittmatter

  • Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.

    Takuya Takahashi;Alyson Fournier;Fumio Nakamura;Li Hsien Wang

  • Rho Kinase Inhibition Enhances Axonal Regeneration in the Injured CNS

    Alyson E. Fournier;Bayan T. Takizawa;Stephen M. Strittmatter

  • Collapsin-induced growth cone collapse mediated by an intracellular protein related to UNC-33

    Yoshio Goshima;Yoshio Goshima;Fumio Nakamura;Philipp Strittmatter;Stephen M. Strittmatter

  • Myelin-Associated Glycoprotein as a Functional Ligand for the Nogo-66 Receptor

    Betty P. Liu;Alyson Fournier;Tadzia GrandPré;Stephen M. Strittmatter

  • Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

    Ji Won Um;Haakon B Nygaard;Jacqueline K Heiss;Mikhail A Kostylev

  • Experience-driven plasticity of visual cortex limited by myelin and Nogo receptor.

    Aaron W. McGee;Yupeng Yang;Quentin S. Fischer;Nigel W. Daw

  • Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein

    Ji Won Um;Adam C. Kaufman;Mikhail Kostylev;Jacqueline K. Heiss

  • Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

    Fenghua Hu;Thihan Padukkavidana;Christian Bjerggaard Vægter;Owen Brady

  • Axon regeneration in young adult mice lacking Nogo-A/B.

    Ji Eun Kim;Shuxin Li;Tadzia GrandPré;Dike Qiu

  • Memory Impairment in Transgenic Alzheimer Mice Requires Cellular Prion Protein

    David A. Gimbel;Haakon B. Nygaard;Erin E. Coffey;Erik C. Gunther

  • Rac1 mediates collapsin-1-induced growth cone collapse.

    Zhao Jin;Stephen M. Strittmatter

  • Neuronal Pathfinding Is Abnormal in Mice Lacking the Neuronal Growth Cone Protein GAP-43

    Stephen M Strittmatter;Stephen M Strittmatter;Christoph Fankhauser;Paul L Huang;Hiroshi Mashimo

  • G0 is a major growth cone protein subject to regulation by GAP-43.

    Stephen M. Strittmatter;Stephen M. Strittmatter;Dario Valenzuela;Dario Valenzuela;Timothy E. Kennedy;Eva J. Neer

  • Localization of Nogo-A and Nogo-66 Receptor Proteins at Sites of Axon–Myelin and Synaptic Contact

    Xingxing Wang;Soo Jin Chun;Helen Treloar;Timothy Vartanian

  • A Family of Rat CRMP Genes Is Differentially Expressed in the Nervous System

    Li-Hsien Wang;Stephen M. Strittmatter

Frequent Co-Authors

Solomon H. Snyder
Solomon H. Snyder Johns Hopkins University School of Medicine
Mark C. Fishman
Mark C. Fishman Harvard University
Robert G. Kalb
Robert G. Kalb Northwestern University
Alyson E. Fournier
Alyson E. Fournier Montreal Neurological Institute and Hospital
Richard E. Carson
Richard E. Carson Yale University
Yiyun Huang
Yiyun Huang Yale University
Yoshio Goshima
Yoshio Goshima Yokohama City University
David A. Lynch
David A. Lynch Children's Hospital of Philadelphia
Nabeel Nabulsi
Nabeel Nabulsi Yale University

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