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Neuroscience

D-Index
121
Citations
51547
World Ranking
377
National Ranking
50

Overview

James W. Fawcett is affiliated with the University of Cambridge in the United Kingdom and has made contributions primarily in the fields of neuroscience, biochemistry, genetics and molecular biology, and medicine. Their research focuses notably on cellular and molecular neuroscience, molecular biology, cell biology, developmental neuroscience, and pathology and forensic medicine.

They have published extensively on topics related to nerve injury and regeneration, proteoglycans and glycosaminoglycans research, neurogenesis and neuroplasticity mechanisms, signaling pathways in disease, spinal cord injury research, neuropeptides and animal physiology, and RNA interference and gene delivery.

Recent scientific papers authored or co-authored by James W. Fawcett include:

  • "Microglia-mediated degradation of perineuronal nets promotes pain" (2022), published in Science
  • "The extracellular matrix and perineuronal nets in memory" (2022), published in Molecular Psychiatry
  • "Optimization of adeno-associated viral vector-mediated transduction of the corticospinal tract: comparison of four promoters" (2020), published in Gene Therapy
  • "Protrudin functions from the endoplasmic reticulum to support axon regeneration in the adult CNS" (2020), published in Nature Communications
  • "Chondroitin 6-sulphate is required for neuroplasticity and memory in ageing" (2021), published in Molecular Psychiatry

Frequent co-authors collaborating with James W. Fawcett include:

  • Jessica C. F. Kwok
  • Pavla Jendelová
  • Joost Verhaagen
  • Lucia Machová Urdzíková
  • Bart Nieuwenhuis

The scientist has published frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Psychiatry
  • Gene Therapy
  • International Journal of Molecular Sciences
  • Frontiers in Cellular Neuroscience

Their work explores complex cellular mechanisms underlying nerve injury, regeneration, and neuroplasticity, examining the role of extracellular matrix components such as perineuronal nets. Investigations into signaling pathways provide insights into disease processes and potential therapeutic strategies.

Best Publications

  • Chondroitinase ABC promotes functional recovery after spinal cord injury

    Elizabeth J. Bradbury;Lawrence D. F. Moon;Lawrence D. F. Moon;Reena J. Popat;Von R. King

  • The glial scar and central nervous system repair

    James W Fawcett;Richard.A Asher

  • Reactivation of Ocular Dominance Plasticity in the Adult Visual Cortex

    Tommaso Pizzorusso;Paolo Medini;Nicoletta Berardi;Sabrina Chierzi

  • Regressive events in neurogenesis

    WM Cowan;JW Fawcett;DD O'Leary;BB Stanfield

  • Peripheral nerve regeneration

    James W. Fawcett;Roger J. Keynes

  • The oligodendrocyte precursor cell in health and disease

    Joel M Levine;Richard Reynolds;James W Fawcett

  • Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials

    J W Fawcett;A Curt;J D Steeves;W P Coleman

  • Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC.

    Lawrence D. F. Moon;Richard A. Asher;Kate E. Rhodes;James W. Fawcett

  • The role of chondroitin sulfate proteoglycans in regeneration and plasticity in the central nervous system.

    Clare M. Galtrey;James W. Fawcett

  • Neurocan is upregulated in injured brain and in cytokine-treated astrocytes.

    Richard A. Asher;Daniel A. Morgenstern;Penny S. Fidler;Kathryn H. Adcock

  • The roles of perineuronal nets and the perinodal extracellular matrix in neuronal function

    James W. Fawcett;Toshitaka Oohashi;Tommaso Pizzorusso

  • Animals lacking link protein have attenuated perineuronal nets and persistent plasticity

    Daniela Carulli;Tommaso Pizzorusso;Jessica C. F. Kwok;Elena Putignano

  • Chondroitin sulphate proteoglycans in the CNS injury response.

    Daniel A Morgenstern;Richard A Asher;James W Fawcett

  • Assembly of a new growth cone after axotomy: the precursor to axon regeneration

    Frank Bradke;James W. Fawcett;Micha E. Spira

  • Can experiments in nonhuman primates expedite the translation of treatments for spinal cord injury in humans

    Grégoire Courtine;Mary Bartlett Bunge;James W Fawcett;Robert G Grossman

  • Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation.

    Guillermo García-Alías;Stanley Barkhuysen;Miranda Buckle;James W Fawcett

  • Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures

    J. D. Steeves;D. Lammertse;A. Curt;J. W. Fawcett

  • The migration of neural crest cells and the growth of motor axons through the rostral half of the chick somite.

    M. Rickmann;J. W. Fawcett;R. J. Keynes

  • Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration

    Poonam Verma;Sabrina Chierzi;Amanda M. Codd;Douglas Simon Campbell

  • The perineuronal net and the control of CNS plasticity

    Difei Wang;James Fawcett

Frequent Co-Authors

Stephen B. Dunnett
Stephen B. Dunnett Cardiff University
Stéphanie P. Lacour
Stéphanie P. Lacour École Polytechnique Fédérale de Lausanne
Joost Verhaagen
Joost Verhaagen Netherlands Institute for Neuroscience
Stephen B. McMahon
Stephen B. McMahon King's College London
Herbert M. Geller
Herbert M. Geller National Institutes of Health
John D. Steeves
John D. Steeves University of British Columbia
Mark H. Tuszynski
Mark H. Tuszynski University of California, San Diego
Elizabeth J. Bradbury
Elizabeth J. Bradbury King's College London
Andreas Faissner
Andreas Faissner Ruhr University Bochum
Tommaso Pizzorusso
Tommaso Pizzorusso University of Florence

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