World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
80
Citations
35039
World Ranking
1599
National Ranking
785

Research.com Recognitions

  • 2000 - Fellow of Alfred P. Sloan Foundation

Overview

Zhigang He is affiliated with Boston Children's Hospital in the United States and conducts research primarily in the fields of Neuroscience, Medicine, and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Cellular and Molecular Neuroscience, Molecular Biology, Developmental Neuroscience, Neurology, and Pathology and Forensic Medicine.

The main topics of Zhigang He's research include:

  • Nerve injury and regeneration
  • Neurogenesis and neuroplasticity mechanisms
  • Retinal Development and Disorders
  • Spinal Cord Injury Research
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Neuroscience and Neuropharmacology Research
  • Axon Guidance and Neuronal Signaling

Recent publications by Zhigang He demonstrate involvement in research addressing cellular and molecular aspects of nervous system repair and neurodegeneration. Notable papers include:

  • "Reprogramming to recover youthful epigenetic information and restore vision," 2020, published in Nature
  • "Microglia-organized scar-free spinal cord repair in neonatal mice," 2020, published in Nature
  • "Solving neurodegeneration: common mechanisms and strategies for new treatments," 2022, published in Molecular Neurodegeneration
  • "Microglia coordinate cellular interactions during spinal cord repair in mice," 2022, published in Nature Communications
  • "Axon Regeneration in the Mammalian Optic Nerve," 2020, published in Annual Review of Vision Science

Zhigang He frequently collaborates with other researchers. Regular co-authors include Anne Jacobi, Joshua R. Sanes, Huyan Meng, Wenjun Yan, and Clifford J. Woolf. Collaboration networks highlight multi-disciplinary approaches within their research community.

Publications by Zhigang He often appear in venues specialized in biomedical research and neuroscience. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Neuron
  • Nature
  • Molecular Neurodegeneration

Among awards received, Zhigang He was named a Fellow of the Alfred P. Sloan Foundation in 2000, recognizing contributions to their fields of study.

Best Publications

  • Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

    Kevin Kyungsuk Park;Kai Liu;Yang Hu;Patrice D. Smith

  • Glial inhibition of CNS axon regeneration

    Glenn C Yiu;Zhigang He

  • Neuropilin Is a Receptor for the Axonal Chemorepellent Semaphorin III

    Zhigang He;Marc Tessier-Lavigne

  • Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates.

    Luca Tamagnone;Stefania Artigiani;Hang Chen;Zhigang He

  • Oligodendrocyte-myelin glycoprotein is a Nogo receptor ligand that inhibits neurite outgrowth.

    Kevin C. Wang;Vuk Koprivica;Jieun A. Kim;Rajeev Sivasankaran

  • PTEN deletion enhances the regenerative ability of adult corticospinal neurons

    Kai Liu;Yi Lu;Jae K Lee;Ramsey Samara

  • P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.

    Kevin C. Wang;Jieun A. Kim;Rajeev Sivasankaran;Rosalind Segal

  • Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides.

    Hong Jun Song;Guo Li Ming;Zhigang He;Maxime Lehmann

  • Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

    Hang Chen;Alain Chédotal;Zhigang He;Corey S Goodman

  • Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

    Fang Sun;Kevin K. Park;Stephane Belin;Dongqing Wang

  • Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth.

    Marco Domeniconi;Zixuan Cao;Timothy Spencer;Rajeev Sivasankaran

  • PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

    Yingjie Shen;Alan P. Tenney;Sarah A. Busch;Kevin P. Horn

  • LINGO-1 negatively regulates myelination by oligodendrocytes.

    Sha Mi;Robert H Miller;Xinhua Lee;Martin L Scott

  • Reprogramming to recover youthful epigenetic information and restore vision.

    Yuancheng Lu;Benedikt Brommer;Benedikt Brommer;Xiao Tian;Anitha Krishnan

  • Intrinsic Control of Axon Regeneration

    Zhigang He;Yishi Jin

  • Cortical representations of olfactory input by trans-synaptic tracing

    Kazunari Miyamichi;Fernando Amat;Farshid Moussavi;Chen Wang

  • Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes.

    Nicholas M. Tran;Karthik Shekhar;Irene E. Whitney;Anne Jacobi

  • A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors

    Jong Bae Park;Glenn C Yiu;Shinjiro Kaneko;Jing Wang

  • SOCS3 Deletion Promotes Optic Nerve Regeneration In Vivo

    Patrice D. Smith;Fang Sun;Kevin Kyungsuk Park;Bin Cai

  • RPA involvement in the damage-recognition and incision steps of nucleotide excision repair

    Zhigang He;L. A. Henricksen;M. S. Wold;C. J. Ingles

  • Subtype-Specific Regeneration of Retinal Ganglion Cells following Axotomy: Effects of Osteopontin and mTOR Signaling

    Xin Duan;Mu Qiao;Fengfeng Bei;In-Jung Kim

  • Neuronal Intrinsic Mechanisms of Axon Regeneration

    Kai Liu;Andrea Tedeschi;Kevin Kyungsuk Park;Zhigang He

Frequent Co-Authors

Marc Tessier-Lavigne
Marc Tessier-Lavigne Xaira Therapeutics
Jieun Kim
Jieun Kim Stanford University
Guo Li Ming
Guo Li Ming University of Pennsylvania
Larry I. Benowitz
Larry I. Benowitz Harvard Medical School
Hongjun Song
Hongjun Song University of Pennsylvania
Clifford J. Woolf
Clifford J. Woolf Boston Children's Hospital
Liqun Luo
Liqun Luo Stanford University
Joshua R. Sanes
Joshua R. Sanes Harvard University
Daniel H. Geschwind
Daniel H. Geschwind University of California, Los Angeles

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