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Neuroscience

D-Index
92
Citations
22409
World Ranking
1043
National Ranking
32

Overview

Joost Verhaagen is affiliated with Vrije Universiteit Amsterdam in the Netherlands. Their research spans fields primarily in Biochemistry, Genetics and Molecular Biology, Neuroscience, and Medicine. Notable subfields include Molecular Biology, Cellular and Molecular Neuroscience, Genetics, Developmental Neuroscience, and Physiology.

The central themes of Verhaagen's work focus on nerve injury and regeneration, neurogenesis and neuroplasticity mechanisms, and virus-based gene therapy research. Additional areas of study include RNA interference and gene delivery, Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, and axon guidance and neuronal signaling.

Verhaagen has contributed to several recent papers, including:

  • ORANGE: A CRISPR/Cas9-based genome editing toolbox for epitope tagging of endogenous proteins in neurons, 2020, PLoS Biology
  • Semaphorins in Adult Nervous System Plasticity and Disease, 2021, Frontiers in Synaptic Neuroscience
  • An Extracellular Perspective on CNS Maturation: Perineuronal Nets and the Control of Plasticity, 2021, International Journal of Molecular Sciences
  • Cerebellar plasticity and associative memories are controlled by perineuronal nets, 2020, Proceedings of the National Academy of Sciences
  • Reversible CD8 T cell-neuron cross-talk causes aging-dependent neuronal regenerative decline, 2022, Science

Frequent coauthors include Fred de Winter, Inge Huitinga, Barbara Hobo, James W. Fawcett, and Dick F. Swaab. These collaborations reflect involvement in multidisciplinary and integrative research projects.

Verhaagen's publications are often found in venues such as Alzheimer's & Dementia, bioRxiv (Cold Spring Harbor Laboratory), International Journal of Molecular Sciences, Acta Neuropathologica Communications, and Molecular Therapy - Methods & Clinical Development. These journals indicate an emphasis on translational research bridging molecular biology and clinical applications.

Best Publications

  • Brain-derived neurotrophic factor in the ventral midbrain-nucleus accumbens pathway: a role in depression.

    Amelia J Eisch;Carlos A Bolaños;Joris de Wit;Ryan D Simonak

  • Alteration of the microRNA network during the progression of Alzheimer's disease.

    Pierre Lau;Koen Bossers;Rekin's Janky;Evgenia Salta

  • The expression of the growth associated protein B50/GAP43 in the olfactory system of neonatal and adult rats.

    J Verhaagen;AB Oestreicher;WH Gispen;FL Margolis

  • ALS as a distal axonopathy : molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease

    Elizabeth B. Moloney;Fred de Winter;Fred de Winter;Joost Verhaagen;Joost Verhaagen

  • Expression of growth-associated protein B-50 (GAP43) in dorsal root ganglia and sciatic nerve during regenerative sprouting.

    Ce Van der Zee;HB Nielander;JP Vos;S Lopes da Silva

  • Injury-induced class 3 semaphorin expression in the rat spinal cord.

    F. De Winter;M. Oudega;A.J. Lankhorst;F.P. Hamers

  • AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells

    Sarah G Leaver;Q Cui;Q Cui;Gary W Plant;Ajanthy Arulpragasam

  • Expression of the gene encoding the chemorepellent semaphorin III is induced in the fibroblast component of neural scar tissue formed following injuries of adult but not neonatal CNS.

    R.J. Pasterkamp;R.J. Giger;M.J. Ruitenberg;A.J.G.D. Holtmaat

  • Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

    Koen Bossers;Kerstin T.S. Wirz;Gideon F. Meerhoff;Anke H.W. Essing

  • B-50, the growth associated protein-43: modulation of cell morphology and communication in the nervous system

    Unknown

  • Phenotypic Characterization of Retinoic Acid Differentiated SH-SY5Y Cells by Transcriptional Profiling

    Joanna A. Korecka;Ronald E. van Kesteren;Eva Blaas;Sonia O. Spitzer

  • Neuroplasticity in the olfactory system : Differential effects of central and peripheral lesions of the primary olfactory pathway on the expression of B 50/GAP43 and the olfactory marker protein

    J. Verhaagen;A. B. Oestreicher;M. Grillo;Y.-S. Khew-Goodall

  • Purification of recombinant adeno-associated virus by iodixanol gradient ultracentrifugation allows rapid and reproducible preparation of vector stocks for gene transfer in the nervous system.

    Wim T.J.M.C. Hermens;Olivier Ter Brake;Paul A. Dijkhuizen;Marc A.F. Sonnemans

  • Comparison of AAV serotypes for gene delivery to dorsal root ganglion neurons.

    Matthew R J Mason;Erich M E Ehlert;Ruben Eggers;Chris W Pool

  • Analysis of Gene Expression in Parkinson's Disease: Possible Involvement of Neurotrophic Support and Axon Guidance in Dopaminergic Cell Death

    Koen Bossers;Gideon Meerhoff;Rawien Balesar;Jeroen W. Van Dongen

  • Evidence for a Role of the Chemorepellent Semaphorin III and Its Receptor Neuropilin-1 in the Regeneration of Primary Olfactory Axons

    R. Jeroen Pasterkamp;Fred De Winter;Anthony J. G. D. Holtmaat;Joost Verhaagen

  • Anatomy of rat semaphorin III collapsin‐1 mRNA expression and relationship to developing nerve tracts during neuroembryogenesis

    Roman J. Giger;David P. Wolfer;Gerard M.J. De Wit;Joost Verhaagen

  • The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease

    Fred De Winter;Tarn Vo;Floor J. Stam;Liselijn A. B. Wisman

  • Olfactory ensheathing glia : their contribution to primary olfactory nervous system regeneration and their regenerative potential following transplantation into the injured spinal cord

    Elske H.P. Franssen;Freddy M. de Bree;Joost Verhaagen

  • Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration, Lesion Size, and Functional Recovery after Implantation in the Injured Rat Spinal Cord

    Marc J. Ruitenberg;Giles W. Plant;Frank P. T. Hamers;Joke Wortel

  • Large-scale chondroitin sulfate proteoglycan digestion with chondroitinase gene therapy leads to reduced pathology and modulates macrophage phenotype following spinal cord contusion injury.

    Katalin Bartus;Nicholas D. James;Athanasios Didangelos;Karen D. Bosch

Frequent Co-Authors

Dick F. Swaab
Dick F. Swaab Royal Netherlands Academy of Arts and Sciences
James W. Fawcett
James W. Fawcett University of Cambridge
August B. Smit
August B. Smit Vrije Universiteit Amsterdam
Anthony Holtmaat
Anthony Holtmaat University of Geneva
Alan R. Harvey
Alan R. Harvey University of Western Australia
Elly M. Hol
Elly M. Hol Utrecht University
Roman J. Giger
Roman J. Giger University of Michigan–Ann Arbor
Joris de Wit
Joris de Wit KU Leuven
Qi Cui
Qi Cui Chinese University of Hong Kong
Elizabeth J. Bradbury
Elizabeth J. Bradbury King's College London

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