D-Index & Metrics Best Publications
Bart De Strooper

Bart De Strooper

Biology and Biochemistry
Belgium
2022

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 124 Citations 52,459 368 World Ranking 222 National Ranking 3

Research.com Recognitions

Awards & Achievements

2022 - Research.com Biology and Biochemistry in Belgium Leader Award

2018 - The Brain Prize, Lundbeck Foundation For their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain'

2013 - Fellow of the American Association for the Advancement of Science (AAAS)

2011 - Member of Academia Europaea

2007 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

2002 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology

2002 - Sedgwick Memorial Medal, American Public Health Association

Fellow of The Academy of Medical Sciences, United Kingdom

Member of the European Molecular Biology Organization (EMBO)

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Genetics

His primary areas of study are Amyloid precursor protein, Cell biology, Alzheimer's disease, Biochemistry and Amyloid precursor protein secretase. His Amyloid precursor protein study combines topics from a wide range of disciplines, such as Molecular biology, Gamma secretase, Presenilin and Loss function. His Cell biology research is multidisciplinary, relying on both Mutation and Genetics.

His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Proteases, Receptor, Neuroscience and Amyloid. His Biochemistry study incorporates themes from Biophysics, P3 peptide and Alpha secretase. His Amyloid precursor protein secretase research incorporates themes from Endocrinology, Signal transduction, Regulated Intramembrane Proteolysis and Intracellular.

His most cited work include:

  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. (1850 citations)
  • Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein (1594 citations)
  • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. (1370 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Cell biology, Amyloid precursor protein, Presenilin, Neuroscience and Biochemistry. As a member of one scientific family, Bart De Strooper mostly works in the field of Cell biology, focusing on PINK1 and, on occasion, Mitochondrion. His research on Amyloid precursor protein concerns the broader Alzheimer's disease.

His Presenilin research incorporates elements of Mutant, Transmembrane protein, Molecular biology, Endoplasmic reticulum and Membrane protein. His studies in Neuroscience integrate themes in fields like Disease, Neurodegeneration and Microglia. His Biochemistry research incorporates themes from Biophysics and Nicastrin.

He most often published in these fields:

  • Cell biology (45.45%)
  • Amyloid precursor protein (39.20%)
  • Presenilin (29.17%)

What were the highlights of his more recent work (between 2015-2021)?

  • Neuroscience (35.23%)
  • Cell biology (45.45%)
  • Disease (25.57%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Neuroscience, Cell biology, Disease, Neurodegeneration and Microglia. His Neuroscience research is multidisciplinary, relying on both Alzheimer's disease, Amyloid beta and Stem cell. His work deals with themes such as RNA, Biochemistry, Mutant, PINK1 and Amyloid precursor protein secretase, which intersect with Cell biology.

His Disease and Dementia, Amyloid precursor protein and Amyloid investigations all form part of his Disease research activities. The various areas that he examines in his Amyloid precursor protein study include Phenotype, Cell and Presenilin. The study incorporates disciplines such as Mutation and Molecular biology in addition to Presenilin.

Between 2015 and 2021, his most popular works were:

  • The Cellular Phase of Alzheimer’s Disease (667 citations)
  • The Cellular Phase of Alzheimer’s Disease (667 citations)
  • Melanoma addiction to the long non-coding RNA SAMMSON. (281 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

Bart De Strooper focuses on Neuroscience, Neurodegeneration, Cell biology, Alzheimer's disease and Amyloid precursor protein. His Neuroscience research incorporates elements of Amyloid beta, Disease, Stem cell, Cognitive decline and Synaptic vesicle. His primary area of study in Cell biology is in the field of Gamma secretase.

His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Cancer research and Downregulation and upregulation. His research in Amyloid precursor protein is mostly concerned with Amyloid precursor protein secretase. His Presenilin study combines topics from a wide range of disciplines, such as Mutation and Biochemistry.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig.
Nature (1999)

2509 Citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele.
Nature (1998)

2225 Citations

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

Eric Karran;Marc Mercken;Bart De Strooper.
Nature Reviews Drug Discovery (2011)

2018 Citations

The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

Iryna Benilova;Eric Karran;Bart De Strooper.
Nature Neuroscience (2012)

1753 Citations

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther.
Proceedings of the National Academy of Sciences of the United States of America (1998)

1448 Citations

OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

Christian Frezza;Sara Cipolat;Olga Martins de Brito;Massimo Micaroni.
Cell (2006)

1423 Citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

Bart De Strooper.
Neuron (2003)

1211 Citations

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

Sébastien S. Hébert;Katrien Horré;Laura Nicolaï;Aikaterini S. Papadopoulou.
Proceedings of the National Academy of Sciences of the United States of America (2008)

1121 Citations

The Cellular Phase of Alzheimer’s Disease

Bart De Strooper;Bart De Strooper;Eric Karran;Eric Karran.
Cell (2016)

855 Citations

The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts.
Human Molecular Genetics (2002)

770 Citations

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