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Bart De Strooper

Bart De Strooper

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Neuroscience
Belgium
2026
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Biology and Biochemistry
Belgium
2023

D-Index & Metrics

Neuroscience

D-Index
148
Citations
81539
World Ranking
153
National Ranking
1

Medicine

D-Index
149
Citations
83220
World Ranking
1201
National Ranking
13

Research.com Recognitions

  • 2026 - Research.com Neuroscience in Belgium Leader Award
  • 2025 - Research.com Neuroscience in Belgium Leader Award
  • 2023 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2022 - Research.com Biology and Biochemistry in Belgium Leader Award
  • 2018 - The Brain Prize, Lundbeck Foundation For their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain'
  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2011 - Member of Academia Europaea
  • 2007 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 2002 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
  • 2002 - Sedgwick Memorial Medal, American Public Health Association
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Bart De Strooper is affiliated with KU Leuven in Belgium and specializes in research within Medicine, Neuroscience, and Biochemistry, Genetics and Molecular Biology. Their work spans several subfields, namely Neurology, Molecular Biology, Physiology, Immunology, and Cellular and Molecular Neuroscience.

The scientist's research focuses predominantly on Alzheimer's disease research and treatments, as well as neuroinflammation and neurodegeneration mechanisms. Additional topics of interest include immune cells in cancer, neurogenesis and neuroplasticity mechanisms, neuroscience and neuropharmacology research, nuclear receptors and signaling pathways, and monoclonal and polyclonal antibodies research.

Bart De Strooper has published frequently in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Alzheimer s & Dementia
  • Molecular Neurodegeneration
  • Cell Reports
  • Acta Neuropathologica

Among notable recent papers are:

  • Reactive astrocyte nomenclature, definitions, and future directions, 2021, Nature Neuroscience
  • Microglia states and nomenclature: A field at its crossroads, 2022, Neuron
  • Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease, 2020, Cell
  • The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics, 2022, Nature Reviews Drug Discovery
  • The β-Secretase BACE1 in Alzheimer's Disease, 2020, Biological Psychiatry

Frequent coauthors include Mark Fiers, Lutgarde Serneels, Dietmar Rudolf Thal, Renzo Mancuso, and Leen Wolfs, with whom they have collaborated extensively.

Awards received by Bart De Strooper include The Brain Prize from the Lundbeck Foundation in 2018 for research on the genetic and molecular basis of Alzheimer's disease, the Fellowship of the American Association for the Advancement of Science in 2013, membership in Academia Europaea since 2011, the Metlife Foundation Award for Medical Research in Alzheimer's Disease in 2007, the Sedgwick Memorial Medal from the American Public Health Association in 2002, and the Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases from the American Academy of Neurology in 2002. They are also a member of the European Molecular Biology Organization and a Fellow of The Academy of Medical Sciences in the United Kingdom.

Best Publications

  • A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.

    Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig

  • The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.

    Eric Karran;Marc Mercken;Bart De Strooper

  • Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

    Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele

  • The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes

    Iryna Benilova;Eric Karran;Bart De Strooper

  • Reactive astrocyte nomenclature, definitions, and future directions

    Carole Escartin;Elena Galea;András Lakatos;James P. O’Callaghan

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • The Cellular Phase of Alzheimer’s Disease

    Bart De Strooper;Bart De Strooper;Eric Karran;Eric Karran

  • OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion

    Christian Frezza;Sara Cipolat;Olga Martins de Brito;Massimo Micaroni

  • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

    Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther

  • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.

    Sébastien S. Hébert;Katrien Horré;Laura Nicolaï;Aikaterini S. Papadopoulou

  • Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

    Bart De Strooper

  • The secretases: enzymes with therapeutic potential in Alzheimer disease

    Bart De Strooper;Robert Vassar;Todd Golde

  • The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.

    Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts

  • Mitochondrial Rhomboid PARL Regulates Cytochrome c Release during Apoptosis via OPA1-Dependent Cristae Remodeling

    Sara Cipolat;Tomasz Rudka;Dieter Hartmann;Veronica Costa

  • Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer's Disease.

    Wei-Ting Chen;Wei-Ting Chen;Ashley Lu;Ashley Lu;Katleen Craessaerts;Katleen Craessaerts;Benjamin Pavie

  • The amyloid hypothesis in Alzheimer disease: new insights from new therapeutics

    Unknown

  • The Major Risk Factors for Alzheimer's Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques.

    Carlo Sala Frigerio;Carlo Sala Frigerio;Leen Wolfs;Nicola Fattorelli;Nicola Thrupp

  • ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.

    Thorsten Maretzky;Karina Reiss;Andreas Ludwig;Julian Buchholz

  • APP mouse models for Alzheimer's disease preclinical studies

    Hiroki Sasaguri;Hiroki Sasaguri;Per Nilsson;Per Nilsson;Shoko Hashimoto;Kenichi Nagata

  • Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

    Huiping Tu;Omar Nelson;Arseny Bezprozvanny;Zhengnan Wang

  • Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

    An Herreman;Dieter Hartmann;Wim Annaert;Paul Saftig

  • Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells.

    An Herreman;Lutgarde Serneels;Wim Annaert;Desiré Collen

  • Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.

    Inna Kuperstein;Kerensa Broersen;Kerensa Broersen;Iryna Benilova;Iryna Benilova;Iryna Benilova;Jef Rozenski

  • ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling

    Karina Reiss;Thorsten Maretzky;Andreas Ludwig;Thomas Tousseyn

  • The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

    Lucía Chávez-Gutiérrez;Leen Bammens;Iryna Benilova;Annelies Vandersteen;Annelies Vandersteen

Frequent Co-Authors

Wim Annaert
Wim Annaert KU Leuven
Paul Saftig
Paul Saftig Kiel University
Rudi D'Hooge
Rudi D'Hooge KU Leuven
Carlos G. Dotti
Carlos G. Dotti Spanish National Research Council
Kris Gevaert
Kris Gevaert Ghent University
Ulrike Müller
Ulrike Müller Heidelberg University
Joris de Wit
Joris de Wit KU Leuven

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