2022 - Research.com Biology and Biochemistry in Belgium Leader Award
2018 - The Brain Prize, Lundbeck Foundation For their groundbreaking research on the genetic and molecular basis of Alzheimer’s disease, with far-reaching implications for the development of new therapeutic interventions as well as for the understanding of other neurodegenerative diseases of the brain'
2013 - Fellow of the American Association for the Advancement of Science (AAAS)
2011 - Member of Academia Europaea
2007 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
2002 - Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases, American Academy of Neurology
2002 - Sedgwick Memorial Medal, American Public Health Association
Fellow of The Academy of Medical Sciences, United Kingdom
Member of the European Molecular Biology Organization (EMBO)
His primary areas of study are Amyloid precursor protein, Cell biology, Alzheimer's disease, Biochemistry and Amyloid precursor protein secretase. His Amyloid precursor protein study combines topics from a wide range of disciplines, such as Molecular biology, Gamma secretase, Presenilin and Loss function. His Cell biology research is multidisciplinary, relying on both Mutation and Genetics.
His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Proteases, Receptor, Neuroscience and Amyloid. His Biochemistry study incorporates themes from Biophysics, P3 peptide and Alpha secretase. His Amyloid precursor protein secretase research incorporates themes from Endocrinology, Signal transduction, Regulated Intramembrane Proteolysis and Intracellular.
His main research concerns Cell biology, Amyloid precursor protein, Presenilin, Neuroscience and Biochemistry. As a member of one scientific family, Bart De Strooper mostly works in the field of Cell biology, focusing on PINK1 and, on occasion, Mitochondrion. His research on Amyloid precursor protein concerns the broader Alzheimer's disease.
His Presenilin research incorporates elements of Mutant, Transmembrane protein, Molecular biology, Endoplasmic reticulum and Membrane protein. His studies in Neuroscience integrate themes in fields like Disease, Neurodegeneration and Microglia. His Biochemistry research incorporates themes from Biophysics and Nicastrin.
The scientist’s investigation covers issues in Neuroscience, Cell biology, Disease, Neurodegeneration and Microglia. His Neuroscience research is multidisciplinary, relying on both Alzheimer's disease, Amyloid beta and Stem cell. His work deals with themes such as RNA, Biochemistry, Mutant, PINK1 and Amyloid precursor protein secretase, which intersect with Cell biology.
His Disease and Dementia, Amyloid precursor protein and Amyloid investigations all form part of his Disease research activities. The various areas that he examines in his Amyloid precursor protein study include Phenotype, Cell and Presenilin. The study incorporates disciplines such as Mutation and Molecular biology in addition to Presenilin.
Bart De Strooper focuses on Neuroscience, Neurodegeneration, Cell biology, Alzheimer's disease and Amyloid precursor protein. His Neuroscience research incorporates elements of Amyloid beta, Disease, Stem cell, Cognitive decline and Synaptic vesicle. His primary area of study in Cell biology is in the field of Gamma secretase.
His Alzheimer's disease research is multidisciplinary, incorporating perspectives in Cancer research and Downregulation and upregulation. His research in Amyloid precursor protein is mostly concerned with Amyloid precursor protein secretase. His Presenilin study combines topics from a wide range of disciplines, such as Mutation and Biochemistry.
This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
Bart De Strooper;Wim Annaert;Philippe Cupers;Paul Saftig.
Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein
Bart De Strooper;Paul Saftig;Paul Saftig;Katleen Craessaerts;Hugo Vanderstichele.
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics.
Eric Karran;Marc Mercken;Bart De Strooper.
Nature Reviews Drug Discovery (2011)
The toxic Aβ oligomer and Alzheimer's disease: an emperor in need of clothes
Iryna Benilova;Eric Karran;Bart De Strooper.
Nature Neuroscience (2012)
Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.
Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther.
Proceedings of the National Academy of Sciences of the United States of America (1998)
OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza;Sara Cipolat;Olga Martins de Brito;Massimo Micaroni.
Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex
Bart De Strooper.
Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression.
Sébastien S. Hébert;Katrien Horré;Laura Nicolaï;Aikaterini S. Papadopoulou.
Proceedings of the National Academy of Sciences of the United States of America (2008)
The Cellular Phase of Alzheimer’s Disease
Bart De Strooper;Bart De Strooper;Eric Karran;Eric Karran.
The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts.
Dieter Hartmann;Bart De Strooper;Lutgarde Serneels;Kathleen Craessaerts.
Human Molecular Genetics (2002)
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