World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
25154
World Ranking
4719
National Ranking
59

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Carlos G. Dotti is affiliated with the Spanish National Research Council in Spain. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Neuroscience. Within these broader areas, their work addresses specialized subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Neurology, Physiology, and Cancer Research.

Their research covers several key topics, including:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Extracellular Vesicles in Disease
  • Neuroscience and Neuropharmacology Research
  • RNA Interference and Gene Delivery
  • Alzheimer's Disease Research and Treatments
  • MicroRNA in Disease Regulation
  • RNA Regulation and Disease

Among their recent publications are the following papers:

  • "Increased exosome secretion in neurons aging in vitro by NPC1-mediated endosomal cholesterol buildup" (2021), published in Life Science Alliance
  • "Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology" (2020), published in Frontiers in Neuroscience
  • "Plasma membrane and brain dysfunction of the old: Do we age from our membranes?" (2022), published in Frontiers in Cell and Developmental Biology
  • "Cognitive decline in diabetic mice predisposed to Alzheimer's disease is greater than in wild type" (2023), published in Life Science Alliance
  • "Bioelectric stimulation outperforms brain derived neurotrophic factor in promoting neuronal maturation" (2025), published in Scientific Reports

The main publication venues where Carlos G. Dotti has contributed include:

  • Life Science Alliance
  • Scientific Reports
  • International Journal of Molecular Sciences
  • Frontiers in Neuroscience
  • Frontiers in Cell and Developmental Biology

Frequent collaborators in Carlos G. Dotti's research are:

  • Francesc X. Guix
  • Marta Carús-Cadavieco
  • Inés Berenguer
  • Miguel A. Serrano-Lope
  • Álvaro Casadomé-Perales

They have been recognized as a Member of the European Molecular Biology Organization (EMBO), reflecting their professional standing in the scientific community.

Best Publications

  • Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons.

    Mikael Simons;Patrick Keller;Bart De Strooper;Konrad Beyreuther

  • Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

    Tobias Hartmann;Sophie C. Bieger;Babara Brühl;Pentti J. Tienari

  • The Role of Local Actin Instability in Axon Formation

    Frank Bradke;Carlos G. Dotti

  • Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation.

    Poul H. Jensen;Morten S. Nielsen;Ross Jakes;Carlos G. Dotti

  • Polarized sorting of viral glycoproteins to the axon and dendrites of hippocampal neurons in culture

    Carlos G. Dotti;Kai Simons

  • The subcellular organization of Madin-Darby canine kidney cells during the formation of a polarized epithelium.

    Robert Bacallao;C. Antony;C. Dotti;E. Karsenti

  • Chemical stimulation of synaptosomes modulates alpha -Ca2+/calmodulin-dependent protein kinase II mRNA association to polysomes.

    Claudia Bagni;Liliana Mannucci;Carlos G. Dotti;Francesco Amaldi

  • Neuronal membrane cholesterol loss enhances amyloid peptide generation

    Jose Abad-Rodriguez;Maria Dolores Ledesma;Katleen Craessaerts;Simona Perga

  • Axonal Membrane Proteins Are Transported in Distinct Carriers: A Two-Color Video Microscopy Study in Cultured Hippocampal Neurons

    Christoph Kaether;Paul Skehel;Carlos G. Dotti

  • Axonal and dendritic endocytic pathways in cultured neurons

    Robert G. Parton;Kai Simons;Carlos G. Dotti

  • Cholesterol in brain disease: sometimes determinant and frequently implicated

    Mauricio Gerardo Martín;Frank Pfrieger;Carlos G. Dotti

  • Microtubule-dependent recruitment of Staufen-green fluorescent protein into large RNA-containing granules and subsequent dendritic transport in living hippocampal neurons.

    Martin Köhrmann;Ming Luo;Christoph Kaether;Luc DesGroseillers

  • The mammalian Staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: Implications for its involvement in mRNA transport

    Michael A. Kiebler;Indradeo Hemraj;Paul Verkade;Martin Köhrmann

  • Neuronal polarity: essential role of protein-lipid complexes in axonal sorting.

    Maria Dolores Ledesma;Kai Simons;Carlos G. Dotti

  • Neuronal Polarity: Vectorial Cytoplasmic Flow Precedes Axon Formation

    Frank Bradke;Carlos G Dotti

  • RhoA/ROCK regulation of neuritogenesis via profilin IIa-mediated control of actin stability.

    Jorge Santos Da Silva;Miguel Medina;Cecilia Zuliani;Alessia Di Nardo

  • Polarized sorting of glypiated proteins in hippocampal neurons.

    Carlos G. Dotti;Robert G. Parton;Kai Simons

  • Establishment of neuronal polarity: lessons from cultured hippocampal neurons.

    Frank Bradke;Carlos G Dotti

  • EEA1, a tethering protein of the early sorting endosome, shows a polarized distribution in hippocampal neurons, epithelial cells, and fibroblasts.

    Jean M Wilson;Meltsje De Hoop;Natasha Zorzi;Ban-Hock Hock Toh

  • Brain plasmin enhances APP α‐cleavage and Aβ degradation and is reduced in Alzheimer's disease brains

    Maria Dolores Ledesma;Jorge Santos Da Silva;Katleen Crassaerts;Andre Delacourte

Frequent Co-Authors

Kai Simons
Kai Simons Lipotype
Robert G. Parton
Robert G. Parton University of Queensland
Claudia Bagni
Claudia Bagni University of Rome Tor Vergata
Rudi D'Hooge
Rudi D'Hooge KU Leuven
Ulrike Müller
Ulrike Müller Heidelberg University
Elina Ikonen
Elina Ikonen University of Helsinki
Giuseppe Legname
Giuseppe Legname International School for Advanced Studies

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