World's Best Scientists 2026 revealed!

D-Index & Metrics

Neuroscience

D-Index
129
Citations
89313
World Ranking
280
National Ranking
171

Biology and Biochemistry

D-Index
129
Citations
89233
World Ranking
412
National Ranking
267

Research.com Recognitions

  • 1981 - Fellow of Alfred P. Sloan Foundation

Overview

Ralph A. Nixon is a researcher affiliated with the Nathan Kline Institute for Psychiatric Research in the United States. Their work primarily focuses on biochemistry, genetics, and molecular biology, with significant contributions to medicine. Throughout their career, they have specialized in subfields including molecular biology, physiology, cell biology, epidemiology, and neurology.

The main research topics associated with Ralph A. Nixon include:

  • Autophagy in Disease and Therapy
  • Cellular transport and secretion
  • Alzheimer's disease research and treatments
  • Calcium signaling and nucleotide metabolism
  • Retinal Development and Disorders
  • Endoplasmic Reticulum Stress and Disease
  • Mitochondrial Function and Pathology

They have published extensively in several notable scientific venues, with frequent publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience
  • Cell Reports
  • Science Advances
  • Autophagy

Ralph A. Nixon's recent publications include the following:

  • "Mechanisms of autophagy-lysosome dysfunction in neurodegenerative diseases" (2024), Nature Reviews Molecular Cell Biology
  • "Faulty autolysosome acidification in Alzheimer's disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques" (2022), Nature Neuroscience
  • "Alzheimer disease" (2021), Nature Reviews Disease Primers
  • "Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies" (2021), Frontiers in Neuroscience
  • "Neurofilaments: neurobiological foundations for biomarker applications" (2020), Brain

The researcher collaborates frequently with others, with notable coauthors including:

  • Philip Stavrides
  • Chris N. Goulbourne
  • Ju-Hyun Lee
  • Dun-Sheng Yang
  • James Peddy

In recognition of their academic contributions, Ralph A. Nixon was named a Fellow of the Alfred P. Sloan Foundation in 1981.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • Alzheimer disease

    Unknown

  • The role of autophagy in neurodegenerative disease

    Ralph A Nixon

  • Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

    Christopher Janus;Jacqueline Pearson;JoAnne McLaurin;Paul M. Mathews

  • Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

    Ralph A. Nixon;Ralph A. Nixon;Jerzy Wegiel;Asok Kumar;Asok Kumar;Wai Haung Yu;Wai Haung Yu

  • Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

    Ju Hyun Lee;Ju Hyun Lee;W. Haung Yu;W. Haung Yu;Asok Kumar;Asok Kumar;Sooyeon Lee;Sooyeon Lee

  • Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

    B Boland;A Kumar;S Lee;F M Platt

  • Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

    W Haung Yu;Ana Maria Cuervo;Asok Kumar;Corrinne M. Peterhoff

  • Endocytic Pathway Abnormalities Precede Amyloid β Deposition in Sporadic Alzheimer’s Disease and Down Syndrome : Differential Effects of APOE Genotype and Presenilin Mutations

    Anne M. Cataldo;Corrinne M. Peterhoff;Juan C. Troncoso;Teresa Gomez-Isla

  • Autophagy, amyloidogenesis and Alzheimer disease

    Ralph A. Nixon

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Faulty autolysosome acidification in Alzheimer’s disease mouse models induces autophagic build-up of Aβ in neurons, yielding senile plaques

    Unknown

  • Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

    Ken-Ichi Saito;John S. Elce;James E. Hamos;Ralph A. Nixon

  • Autophagy failure in Alzheimer's disease--locating the primary defect.

    Ralph A. Nixon;Dun-Sheng Yang;Dun-Sheng Yang

  • Neurofilaments and Neurofilament Proteins in Health and Disease.

    Aidong Yuan;Aidong Yuan;Mala V. Rao;Mala V. Rao;Veeranna;Veeranna;Ralph A. Nixon;Ralph A. Nixon

  • Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

    Ahmad Salehi;Jean Dominique Delcroix;Pavel V. Belichenko;Ke Zhan

  • Cdk5 is a key factor in tau aggregation and tangle formation in vivo.

    Wendy Noble;Vicki Olm;Kazuyuki Takata;Evelyn Casey

  • Autophagy and its possible roles in nervous system diseases, damage and repair.

    David C Rubinsztein;Marian DiFiglia;Nathaniel Heintz;Ralph A Nixon

  • Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain.

    Anne M. Cataldo;Ralph A. Nixon

Frequent Co-Authors

Paul M. Mathews
Paul M. Mathews New York University
Asok Kumar
Asok Kumar Nathan Kline Institute for Psychiatric Research
Thomas B. Shea
Thomas B. Shea University of Massachusetts Lowell
Stephen D. Schmidt
Stephen D. Schmidt National Institutes of Health
Karen Duff
Karen Duff University College London
Ana Maria Cuervo
Ana Maria Cuervo Albert Einstein College of Medicine
Donald A. Wilson
Donald A. Wilson Nathan Kline Institute for Psychiatric Research
Stephen D. Ginsberg
Stephen D. Ginsberg Nathan Kline Institute for Psychiatric Research
Yasuo Uchiyama
Yasuo Uchiyama Juntendo University
Peter St George-Hyslop
Peter St George-Hyslop Columbia University

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