World's Best Scientists 2026 revealed!
Li-Huei Tsai

Li-Huei Tsai

Award Badge
Best Female Scientists
2025
Award Badge
Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Female Scientists

D-Index
140
Citations
85513
World Ranking
237
National Ranking
149

Neuroscience

D-Index
139
Citations
90060
World Ranking
201
National Ranking
132

Biology and Biochemistry

D-Index
139
Citations
89819
World Ranking
280
National Ranking
189

Research.com Recognitions

  • 2025 - Research.com Best Female Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2019 - Fellow, National Academy of Inventors
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Li-Huei Tsai is affiliated with MIT in the United States and has contributed extensively to the fields of Medicine and Biochemistry, Genetics and Molecular Biology. Their research intersects several subfields, including Physiology, Immunology, Molecular Biology, Cellular and Molecular Neuroscience, and Biological Psychiatry.

Their research primarily focuses on key topics such as:

  • Alzheimer's disease research and treatments
  • Neuroscience and Neural Engineering
  • Tryptophan and brain disorders
  • Adipose Tissue and Metabolism
  • Interferon and immune responses
  • Immune Response and Inflammation
  • Inflammasome and immune disorders

Recent publications by Li-Huei Tsai include:

  • Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome, 2024, bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular hallmarks of excitatory and inhibitory neuronal resilience and resistance to Alzheimer's disease, 2025, bioRxiv (Cold Spring Harbor Laboratory)
  • No STINGs attached: How APOE-Christchurch dampens Alzheimer's pathology, 2025, Immunity
  • Molecular hallmarks of excitatory and inhibitory neuronal resilience to Alzheimer's disease, 2025, Molecular Neurodegeneration
  • Resolving the mysteries of brain clearance and immune surveillance, 2025, Neuron

Frequent co-authors collaborating with Li-Huei Tsai include:

  • Manolis Kellis
  • Isabel Castanho
  • Pourya Naderi Yeganeh
  • Carles A. Boix
  • Sarah Morgan

They have published notably in venues such as bioRxiv (Cold Spring Harbor Laboratory), Immunity, Molecular Neurodegeneration, and Neuron. Their work encompasses a broad set of disciplines that bridge molecular biology, neuroscience, and immunology.

Li-Huei Tsai has been recognized with the following awards:

  • Fellow, National Academy of Inventors (2019)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2008)

Best Publications

  • Integrative analysis of 111 reference human epigenomes

    Anshul Kundaje;Wouter Meuleman;Wouter Meuleman;Jason Ernst

  • Driving fast-spiking cells induces gamma rhythm and controls sensory responses

    Jessica A. Cardin;Marie Carlén;Marie Carlén;Konstantinos Meletis;Konstantinos Meletis;Ulf Knoblich

  • Single-cell transcriptomic analysis of Alzheimer’s disease

    Hansruedi Mathys;Hansruedi Mathys;Jose Davila-Velderrain;Jose Davila-Velderrain;Zhuyu Peng;Zhuyu Peng;Fan Gao;Fan Gao

  • Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

    Gentry N. Patrick;Lawrence Zukerberg;Margareta Nikolic;Margareta Nikolic;Suzanne de la Monte

  • Microglia states and nomenclature: A field at its crossroads

    Unknown

  • HDAC2 negatively regulates memory formation and synaptic plasticity

    Ji Song Guan;Stephen J. Haggarty;Emanuela Giacometti;Jan Hermen Dannenberg;Jan Hermen Dannenberg

  • A Syndrome of Multiorgan Hyperplasia with Features of Gigantism, Tumorigenesis, and Female Sterility in p27Kip1-Deficient Mice

    Matthew L. Fero;Michael Rivkin;Michael Tasch;Peggy Porter

  • Recovery of learning and memory is associated with chromatin remodelling

    Andre Fischer;Farahnaz Sananbenesi;Xinyu Wang;Xinyu Wang;Xinyu Wang;Matthew Dobbin;Matthew Dobbin;Matthew Dobbin

  • A decade of CDK5.

    Rani Dhavan;Li-Huei Tsai

  • Inhibition of cyclin-dependent kinases by p21.

    J W Harper;S J Elledge;K Keyomarsi;B Dynlacht

  • p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

    Li-Huei Tsai;Ivana Delalle;Verne S. Caviness;Teresa Chae

  • Neurotoxicity induces cleavage of p35 to p25 by calpain

    Ming-sum Lee;Young T. Kwon;Mingwei Li;Junmin Peng

  • Gamma frequency entrainment attenuates amyloid load and modifies microglia

    Hannah F. Iaccarino;Annabelle C. Singer;Anthony J. Martorell;Anthony J. Martorell;Andrii Rudenko;Andrii Rudenko

  • SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.

    Dohoon Kim;Dohoon Kim;Minh Dang Nguyen;Matthew M. Dobbin;Andre Fischer

  • A family of human cdc2-related protein kinases.

    M. Meyerson;G. H. Enders;Chin-Lee Wu;Li-Kuo Su

  • APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.

    Yuan-Ta Lin;Jinsoo Seo;Jinsoo Seo;Fan Gao;Heather M. Feldman

  • A novel pathway regulates memory and plasticity via SIRT1 and miR-134

    Jun Gao;Wen Yuan Wang;Wen Yuan Wang;Ying Wei Mao;Ying Wei Mao;Johannes Gräff;Johannes Gräff

  • Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

    Teresa Chae;Young T. Kwon;Roderick Bronson;Pieter Dikkes

  • Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

    Nir Grossman;David Bono;Nina Dedic;Suhasa B. Kodandaramaiah

  • An epigenetic blockade of cognitive functions in the neurodegenerating brain

    Johannes Gräff;Damien Rei;Damien Rei;Ji-Song Guan;Ji-Song Guan;Wen-Yuan Wang;Wen-Yuan Wang

  • Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

    Yingwei Mao;Xuecai Ge;Xuecai Ge;Xuecai Ge;Christopher L. Frank;Christopher L. Frank;Jon M. Madison

  • The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

    M. Nikolic;H. Dudek;Y. T. Kwon;Y. F. M. Ramos

Frequent Co-Authors

Stephen J. Haggarty
Stephen J. Haggarty Harvard University
Ed Harlow
Ed Harlow Harvard University
David A. Bennett
David A. Bennett Rush University Medical Center
Andre Fischer
Andre Fischer University of Göttingen
Philip L. De Jager
Philip L. De Jager Columbia University
Rachael L. Neve
Rachael L. Neve Harvard University
Matthew Meyerson
Matthew Meyerson Harvard University

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