World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Scientists

D-Index
228
Citations
169851
World Ranking
106
National Ranking
76

Neuroscience

D-Index
229
Citations
168530
World Ranking
11
National Ranking
8

Biology and Biochemistry

D-Index
229
Citations
170298
World Ranking
16
National Ranking
14

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - Nobel Prize for their discoveries concerning signal transduction in the nervous system
  • 1999 - Member of the National Academy of Medicine (NAM)
  • 1998 - Metlife Foundation Award for Medical Research in Alzheimer's Disease
  • 1994 - Ralph W. Gerard Prize in Neuroscience, Society for Neuroscience
  • 1993 - Karl Spencer Lashley Award, The American Philosophical Society For his pioneering work on the molecular basis of signal transduction and vesicle mobilization in nerve cells
  • 1991 - NAS Award in the Neurosciences, U.S. National Academy of Sciences For his discovery of the central role played by neuronal phosphoproteins in normal brain function as well as in neuropsychiatric and related disorders.
  • 1978 - Member of the National Academy of Sciences

Overview

Paul Greengard was affiliated with Rockefeller University in the United States. Their research primarily focused on neuroscience, biochemistry, genetics, molecular biology, and medicine.

The scientist contributed extensively to subfields including molecular biology, cellular and molecular neuroscience, physiology, neurology, and genetics. Their work covered a range of topics such as Alzheimer's disease research and treatments, neuroinflammation and neurodegeneration mechanisms, neuroscience and neuropharmacology research, receptor mechanisms and signaling, neurotransmitter receptor influence on behavior, genetics and neurodevelopmental disorders, and immune cells in cancer.

Some of the recent papers authored or coauthored by the scientist include:

  • The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease, 2020, Nature
  • Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis, 2020, Neuron
  • Serotonin receptor 4 in the hippocampus modulates mood and anxiety, 2021, Molecular Psychiatry
  • Ependymal cells-CSF flow regulates stress-induced depression, 2021, Molecular Psychiatry
  • AP-1 controls the p11-dependent antidepressant response, 2020, Molecular Psychiatry

Frequent coauthors included Lucian Medrihan, Jean-Pierre Roussarie, Marc Flajolet, Wei Wang, and Olga G. Troyanskaya.

The scientist published frequently in venues such as bioRxiv (Cold Spring Harbor Laboratory), Molecular Psychiatry, Biological Psychiatry, PLoS ONE, and Nature.

Throughout their career, Paul Greengard received several awards, including:

  • Nobel Prize in 2000 for discoveries concerning signal transduction in the nervous system
  • Fellow of the American Association for the Advancement of Science (AAAS) in 2004
  • Member of the National Academy of Medicine (NAM) in 1999
  • Metlife Foundation Award for Medical Research in Alzheimer's Disease in 1998
  • Ralph W. Gerard Prize in Neuroscience from the Society for Neuroscience in 1994
  • Karl Spencer Lashley Award from The American Philosophical Society in 1993 for pioneering work on signal transduction and vesicle mobilization in nerve cells
  • NAS Award in the Neurosciences from the U.S. National Academy of Sciences in 1991 for discovering the role of neuronal phosphoproteins in brain function and neuropsychiatric disorders
  • Member of the National Academy of Sciences in 1978

Best Publications

  • Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor

    Noboru Sato;Laurent Meijer;Laurent Meijer;Leandros Skaltsounis;Paul Greengard

  • Regulation of NMDA receptor trafficking by amyloid-beta.

    Eric M Snyder;Yi Nong;Claudia G Almeida;Surojit Paul

  • Correlation Between Elevated Levels of Amyloid β-Peptide in the Brain and Cognitive Decline

    Jan Näslund;Vahram Haroutunian;Richard Mohs;Kenneth L. Davis

  • Synaptic Vesicle Phosphoproteins and Regulation of Synaptic Function

    Paul Greengard;Flavia Valtorta;Andrew J. Czernik;Fabio Benfenati

  • Phosphorylated proteins as physiological effectors

    Paul Greengard

  • Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation.

    W B Huttner;W Schiebler;P Greengard;P De Camilli

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • Dichotomous Dopaminergic Control of Striatal Synaptic Plasticity

    Weixing Shen;Marc Flajolet;Paul Greengard;D. James Surmeier

  • A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types

    Myriam Heiman;Anne Schaefer;Shiaoching Gong;Jayms D. Peterson

  • The neurobiology of slow synaptic transmission.

    Paul Greengard

  • A 38,000-dalton membrane protein (p38) present in synaptic vesicles.

    Reinhard Jahn;Werner Schiebler;Charles Ouimet;Paul Greengard

  • Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1.

    Jonathan Goldberg;Hsien Bin Huang;Young Guen Kwon;Paul Greengard

  • Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease A PROPERTY COMMON TO MOST CYCLIN-DEPENDENT KINASE INHIBITORS?

    Sophie Leclerc;Matthieu Garnier;Ralph Hoessel;Doris Marko

  • CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

    J. F. Kuo;Paul Greengard

  • Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types

    Joseph P. Doyle;Joseph D. Dougherty;Myriam Heiman;Eric F. Schmidt

  • Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters

    Paul Greengard

  • GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins

    Laurent Meijer;Alexios-Leandros Skaltsounis;Prokopios Magiatis;Panagiotis Polychronopoulos

  • Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade.

    Paul Greengard;Patrick B. Allen;Angus C. Nairn

  • Dopamine-sensitive adenylate cyclase in caudate nucleus of rat brain, and its similarity to the "dopamine receptor".

    Unknown

  • Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

    Barbara Picconi;Diego Centonze;Kerstin Håkansson;Giorgio Bernardi

  • IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

    Alana G. Lerner;John Paul Upton;P. V.K. Praveen;Rajarshi Ghosh

Frequent Co-Authors

Angus C. Nairn
Angus C. Nairn Yale University
Per Svenningsson
Per Svenningsson Karolinska Institute
Akinori Nishi
Akinori Nishi Kurume University
Andrew J. Czernik
Andrew J. Czernik PhosphoSolutions
Gilberto Fisone
Gilberto Fisone Karolinska Institute
Allen A. Fienberg
Allen A. Fienberg Rockefeller University
Flavia Valtorta
Flavia Valtorta Vita-Salute San Raffaele University
Fabio Benfenati
Fabio Benfenati Italian Institute of Technology
Joseph D. Buxbaum
Joseph D. Buxbaum Icahn School of Medicine at Mount Sinai

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