H-Index & Metrics Top Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry H-index 207 Citations 138,081 550 World Ranking 11 National Ranking 8

Research.com Recognitions

Awards & Achievements

2017 - Fellow of the Royal Society, United Kingdom

2015 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Neurosciences

2013 - Albert Lasker Award for Basic Medical Research, Lasker Foundation

2013 - Fellow, National Academy of Inventors

2013 - Nobel Prize for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells

2010 - Fellow of the American Academy of Arts and Sciences

2010 - Kavli Prize, The Kavli Foundation for discovering the molecular basis of neurotransmitter release

2007 - Member of the National Academy of Medicine (NAM)

2003 - Metlife Foundation Award for Medical Research in Alzheimer's Disease

2002 - Member of the National Academy of Sciences

1999 - Fellow of the American Association for the Advancement of Science (AAAS)

1993 - W. Alden Spencer Award, College of Physicians and Surgeons

Member of the European Academy of Sciences and Arts

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • DNA

Thomas C. Südhof spends much of his time researching Cell biology, Biochemistry, Synaptic vesicle, Synaptotagmin 1 and Neurotransmission. His studies deal with areas such as Neurotransmitter, Synaptic vesicle exocytosis, Exocytosis, Munc-18 and Vesicle fusion as well as Cell biology. His Biochemistry research focuses on subjects like Biophysics, which are linked to Function, Protein folding, Protein structure and Vesicle.

His Synapsin, Active zone, Synaptic vesicle priming and Presynaptic active zone study, which is part of a larger body of work in Synaptic vesicle, is frequently linked to Synaptophysin, bridging the gap between disciplines. His Synaptotagmin 1 study combines topics from a wide range of disciplines, such as STX1A, Synaptotagmins, C2 domain, Complexin and Synaptotagmin I. His Neurotransmission study also includes fields such as

  • Neuroscience which connect with Synaptic plasticity,
  • Neuroligin that connect with fields like Alternative splicing.

His most cited work include:

  • Direct conversion of fibroblasts to functional neurons by defined factors (2336 citations)
  • The synaptic vesicle cycle (1983 citations)
  • The synaptic vesicle cycle: a cascade of protein–protein interactions (1810 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Cell biology, Synaptic vesicle, Neuroscience, Biochemistry and Neurotransmission. His Cell biology study integrates concerns from other disciplines, such as Neurotransmitter, Synaptic vesicle exocytosis, Exocytosis, Vesicle fusion and Synaptotagmin 1. His work investigates the relationship between Synaptotagmin 1 and topics such as Synaptotagmins that intersect with problems in Calcium-binding protein.

Thomas C. Südhof usually deals with Synaptic vesicle and limits it to topics linked to Synaptic augmentation and Synaptic fatigue. His Biochemistry study frequently draws connections between related disciplines such as Biophysics. His studies in Neurotransmission integrate themes in fields like Synaptic plasticity, AMPA receptor and Neurexin.

He most often published in these fields:

  • Cell biology (61.79%)
  • Synaptic vesicle (29.93%)
  • Neuroscience (28.14%)

What were the highlights of his more recent work (between 2015-2021)?

  • Neuroscience (28.14%)
  • Cell biology (61.79%)
  • Synapse (18.90%)

In recent papers he was focusing on the following fields of study:

Thomas C. Südhof mostly deals with Neuroscience, Cell biology, Synapse, Neurotransmission and Postsynaptic potential. His biological study spans a wide range of topics, including Synaptic plasticity and Neurexin. His Cell biology research includes elements of Synaptic vesicle, Synaptotagmin 1, Exocytosis and Transcription factor.

His Synaptotagmin 1 study combines topics in areas such as Synaptotagmins and Complexin. His study in Synapse is interdisciplinary in nature, drawing from both Cerebellum, Function, Synaptogenesis, Teneurin and Cell adhesion. His research integrates issues of Embryonic stem cell, Neurotransmitter, NMDA receptor, AMPA receptor and Calyx of Held in his study of Neurotransmission.

Between 2015 and 2021, his most popular works were:

  • Synaptic Neurexin Complexes: A Molecular Code for the Logic of Neural Circuits (291 citations)
  • Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq (205 citations)
  • Cellular Taxonomy of the Mouse Striatum as Revealed by Single-Cell RNA-Seq (205 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • DNA

His primary scientific interests are in Neuroscience, Cell biology, Postsynaptic potential, Synapse and Neurotransmission. His Cell biology research integrates issues from Genetics, Exocytosis, Transcription factor, Gene targeting and Membrane protein. Thomas C. Südhof has included themes like Synaptic vesicle exocytosis, Active zone and Synaptic vesicle in his Exocytosis study.

Postsynaptic potential is a subfield of Biochemistry that Thomas C. Südhof studies. Thomas C. Südhof combines subjects such as Synaptic plasticity, Plasma protein binding, Teneurin, Transmembrane protein and Signal transduction with his study of Synapse. The study incorporates disciplines such as AMPA receptor, Long-term potentiation, Haploinsufficiency and Autism in addition to Neurotransmission.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Top Publications

The synaptic vesicle cycle

Thomas C. Südhof.
Annual Review of Neuroscience (2004)

3234 Citations

Direct conversion of fibroblasts to functional neurons by defined factors

Thomas Vierbuchen;Austin Ostermeier;Zhiping P. Pang;Yuko Kokubu.
Nature (2010)

3036 Citations

The synaptic vesicle cycle: a cascade of protein–protein interactions

Thomas C. Südhof.
Nature (1995)

2989 Citations

Neuroligins and Neurexins Link Synaptic Function to Cognitive Disease

Thomas C. Südhof.
Nature (2008)

1988 Citations

Membrane fusion: grappling with SNARE and SM proteins.

Thomas C. Südhof;James E. Rothman.
Science (2009)

1829 Citations

A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60

Xinwei Cao;Thomas C. Südhof.
Science (2001)

1801 Citations

Membrane Fusion and Exocytosis

Reinhard Jahn;Thomas C. Südhof.
Annual Review of Biochemistry (1999)

1703 Citations

Synaptotagmin I: A major Ca2+ sensor for transmitter release at a central synapse

Martin Geppert;Yukiko Goda;Robert E. Hammer;Cai Li.
Cell (1994)

1629 Citations

α-Synuclein promotes SNARE-complex assembly in vivo and in vitro

Jacqueline Burre;Manu Sharma;Theodoros Tsetsenis;Vladimir L. Buchman.
Science (2010)

1442 Citations

Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25

Juan Blasi;Juan Blasi;Edwin R. Chapman;Egenhard Link;Thomas Binz.
Nature (1993)

1406 Citations

Profile was last updated on December 6th, 2021.
Research.com Ranking is based on data retrieved from the Microsoft Academic Graph (MAG).
The ranking h-index is inferred from publications deemed to belong to the considered discipline.

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